Detalhe da pesquisa
1.
Identification of azabenzimidazoles as potent JAK1 selective inhibitors.
Bioorg Med Chem Lett
; 26(1): 60-7, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26614408
2.
Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors.
J Med Chem
; 67(2): 1500-1512, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38227216
3.
Discovery of novel Jak2-Stat pathway inhibitors with extended residence time on target.
Bioorg Med Chem Lett
; 23(10): 3105-10, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23562594
4.
Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity.
ACS Med Chem Lett
; 14(12): 1848-1856, 2023 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38116444
5.
STAT3 Antisense Oligonucleotide Remodels the Suppressive Tumor Microenvironment to Enhance Immune Activation in Combination with Anti-PD-L1.
Clin Cancer Res
; 26(23): 6335-6349, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32943458
6.
Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity.
J Immunother Cancer
; 8(2)2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32727810
7.
Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors.
Bioorg Med Chem Lett
; 19(23): 6524-8, 2009 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19857966
8.
Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer.
Bioorg Med Chem Lett
; 18(17): 4794-7, 2008 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18694641
9.
Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells.
J Clin Invest
; 128(12): 5479-5488, 2018 12 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30252677
10.
Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors.
J Med Chem
; 61(12): 5235-5244, 2018 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29856615
11.
Discovery of 1-methyl-1H-imidazole derivatives as potent Jak2 inhibitors.
J Med Chem
; 57(1): 144-58, 2014 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-24359159
12.
Discovery and optimization of a novel series of potent mutant B-Raf(V600E) selective kinase inhibitors.
J Med Chem
; 56(5): 1996-2015, 2013 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23398453
13.
Next-generation sequencing identifies a novel ELAVL1-TYK2 fusion gene in MOLM-16, an AML cell line highly sensitive to the PIM kinase inhibitor AZD1208.
Leuk Lymphoma
; 57(12): 2927-2929, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27189703
14.
Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway.
J Med Chem
; 54(1): 262-76, 2011 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21138246
15.
The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors.
Cancer Cell
; 16(6): 487-97, 2009 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-19962667
16.
Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2.
J Biol Chem
; 283(47): 32334-43, 2008 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-18775810