Detalhe da pesquisa
1.
Identification of potent pan-ephrin receptor kinase inhibitors using DNA-encoded chemistry technology.
Proc Natl Acad Sci U S A
; 121(19): e2322934121, 2024 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38701119
2.
A unified strategy for the total syntheses of eribulin and a macrolactam analogue of halichondrin B.
Proc Natl Acad Sci U S A
; 119(32): e2208938119, 2022 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35930662
3.
CYP3A Mediates an Unusual C(sp2)-C(sp3) Bond Cleavage via Ipso-Addition of Oxygen in Drug Metabolism.
Angew Chem Int Ed Engl
; 63(23): e202405197, 2024 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38574245
4.
Concise Syntheses of Microsomal Metabolites of a Potent OXE (Oxoeicosanoid) Receptor Antagonist.
Chem Pharm Bull (Tokyo)
; 71(7): 534-544, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37394602
5.
The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice.
BMC Biol
; 20(1): 161, 2022 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35831855
6.
A Highly Convergent Total Synthesis of Norhalichondrin B.
J Am Chem Soc
; 143(49): 20970-20979, 2021 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34851106
7.
A Reverse Approach to the Total Synthesis of Halichondrin B.
J Am Chem Soc
; 143(24): 9267-9276, 2021 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34105959
8.
Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic Analysis.
J Org Chem
; 86(4): 3377-3421, 2021 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33544599
9.
Structure-activity relationship study of ß-oxidation resistant indole-based 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) receptor antagonists.
Bioorg Med Chem Lett
; 27(20): 4770-4776, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28943042
10.
Design and synthesis of affinity chromatography ligands for the purification of 5-hydroxyeicosanoid dehydrogenase.
Bioorg Med Chem
; 25(1): 116-125, 2017 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28340986
11.
Base-dependent formation of cis and trans olefins and their application in the synthesis of 5-oxo-ETE receptor antagonists.
Bioorg Med Chem Lett
; 24(15): 3385-8, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24948567
12.
Reversible male contraception by targeted inhibition of serine/threonine kinase 33.
Science
; 384(6698): 885-890, 2024 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38781365
13.
Advancing ASMS with LC-MS/MS for the discovery of novel PDCL2 ligands from DNA-encoded chemical library selections.
Andrology
; 11(5): 808-815, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36209044
14.
Metabolism of anti-inflammatory OXE (oxoeicosanoid) receptor antagonists by nonhuman primates.
Eur J Pharm Sci
; 172: 106144, 2022 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35158054
15.
Targeting the OXE receptor with a selective antagonist inhibits allergen-induced pulmonary inflammation in non-human primates.
Br J Pharmacol
; 179(2): 322-336, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34766334
16.
Inhibition of allergen-induced dermal eosinophilia by an oxoeicosanoid receptor antagonist in non-human primates.
Br J Pharmacol
; 177(2): 360-371, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31655023
17.
Novel highly potent OXE receptor antagonists with prolonged plasma lifetimes that are converted to active metabolites in vivo in monkeys.
Br J Pharmacol
; 177(2): 388-401, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31655025
18.
Novel Highly Potent and Metabolically Resistant Oxoeicosanoid (OXE) Receptor Antagonists That Block the Actions of the Granulocyte Chemoattractant 5-Oxo-6,8,11,14-Eicosatetraenoic Acid (5-oxo-ETE).
J Med Chem
; 61(14): 5934-5948, 2018 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29972644
19.
Metabolism and pharmacokinetics of a potent N-acylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) in rats and monkeys.
Eur J Pharm Sci
; 115: 88-99, 2018 Mar 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-29339225
20.
In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys.
Biochem Pharmacol
; 138: 107-118, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28476332