Detalhe da pesquisa
1.
Small-molecule-induced polymerization triggers degradation of BCL6.
Nature
; 588(7836): 164-168, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33208943
2.
Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15.
Nat Chem Biol
; 16(1): 7-14, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31686031
3.
Asymmetric Synthesis of (-)-6-Desmethyl-Fluvirucinine A1 via Conformationally-Controlled Diastereoselective Lactam-Ring Expansions.
Molecules
; 23(9)2018 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30223428
4.
Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach.
Blood
; 125(20): 3133-43, 2015 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25833960
5.
Induced protein degradation for therapeutics: past, present, and future.
J Clin Invest
; 134(1)2024 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38165043
6.
The human E3 ligase RNF185 is a regulator of the SARS-CoV-2 envelope protein.
iScience
; 26(5): 106601, 2023 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37095859
7.
Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders.
bioRxiv
; 2023 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36824856
8.
TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and EZH2 dependence.
Sci Transl Med
; 15(714): eadi7244, 2023 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37729434
9.
BTBBCL6 dimers as building blocks for reversible drug-induced protein oligomerization.
Cell Rep Methods
; 2(4): 100193, 2022 04 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35497498
10.
Exploring the target scope of KEAP1 E3 ligase-based PROTACs.
Cell Chem Biol
; 29(10): 1470-1481.e31, 2022 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36070758
11.
Identification of Thieno[3,2-d]pyrimidine Derivatives as Dual Inhibitors of Focal Adhesion Kinase and FMS-like Tyrosine Kinase 3.
J Med Chem
; 64(16): 11934-11957, 2021 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34324343
12.
Targeted protein degradation as a powerful research tool in basic biology and drug target discovery.
Nat Struct Mol Biol
; 27(7): 605-614, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32541897
13.
Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface.
ACS Med Chem Lett
; 11(6): 1269-1273, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32551010
14.
Identification of Novel Resorcinol Amide Derivatives as Potent and Specific Pyruvate Dehydrogenase Kinase (PDHK) Inhibitors.
J Med Chem
; 62(18): 8461-8479, 2019 09 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31469962
15.
Identification of a novel 5-amino-3-(5-cyclopropylisoxazol-3-yl)-1-isopropyl-1H-pyrazole-4-carboxamide as a specific RET kinase inhibitor.
Eur J Med Chem
; 125: 1145-1155, 2017 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27814560
16.
In situ imaging of quantum dot-AZD4547 conjugates for tracking the dynamic behavior of fibroblast growth factor receptor 3.
Int J Nanomedicine
; 12: 5345-5357, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28794627
17.
Double Blockade of Glioma Cell Proliferation and Migration by Temozolomide Conjugated with NPPB, a Chloride Channel Blocker.
ACS Chem Neurosci
; 7(3): 275-85, 2016 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26711895
18.
A Pyrazolo[3,4-d]pyrimidin-4-amine Derivative Containing an Isoxazole Moiety Is a Selective and Potent Inhibitor of RET Gatekeeper Mutants.
J Med Chem
; 59(1): 358-73, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26652860