Detalhe da pesquisa
1.
Noncovalent inhibition of C481S Bruton tyrosine kinase by GDC-0853: a new treatment strategy for ibrutinib-resistant CLL.
Blood
; 132(10): 1039-1049, 2018 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30018078
2.
Strategies to Mitigate the Bioactivation of Aryl Amines.
Chem Res Toxicol
; 33(7): 1950-1959, 2020 07 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32508087
3.
Bruton's Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in Rats.
J Pharmacol Exp Ther
; 360(1): 226-238, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27821712
4.
Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability.
Bioorg Med Chem Lett
; 26(2): 575-579, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26675441
5.
Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834.
Bioorg Med Chem Lett
; 25(6): 1333-7, 2015 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25701252
6.
Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis.
Nat Chem Biol
; 7(1): 41-50, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21113169
7.
3-heterocyclyl quinolone inhibitors of the HCV NS5B polymerase.
Bioorg Med Chem Lett
; 22(1): 300-4, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22119470
8.
Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor.
Drug Metab Dispos
; 39(10): 1840-9, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21742900
9.
Quinolones as HCV NS5B polymerase inhibitors.
Bioorg Med Chem Lett
; 21(1): 82-7, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21145235
10.
It Takes a Village: Mentors, Colleagues, Family, and Friends.
ACS Med Chem Lett
; 11(3): 214-216, 2020 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32184944
11.
Stereochemical Differences in Fluorocyclopropyl Amides Enable Tuning of Btk Inhibition and Off-Target Activity.
ACS Med Chem Lett
; 11(8): 1588-1597, 2020 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32832028
12.
The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells.
Sci Signal
; 13(634)2020 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32487715
13.
Women's Healthcare: Call for Action.
J Med Chem
; 2024 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38804614
14.
Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development.
J Med Chem
; 61(6): 2227-2245, 2018 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29457982
15.
Human T cells armed with Her2/neu bispecific antibodies divide, are cytotoxic, and secrete cytokines with repeated stimulation.
Clin Cancer Res
; 12(2): 569-76, 2006 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16428502
16.
Medicinal Chemistry: Where Are All the Women?
ACS Med Chem Lett
; 8(9): 900-902, 2017 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28947931
17.
Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties.
ACS Med Chem Lett
; 8(6): 608-613, 2017 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28626519
18.
Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFNα-driven lupus nephritis.
JCI Insight
; 2(7): e90111, 2017 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28405610
19.
Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations.
ACS Chem Biol
; 11(10): 2897-2907, 2016 10 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-27571029
20.
Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).
J Mol Biol
; 344(2): 527-47, 2004 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-15522303