Detalhe da pesquisa
1.
LLF580, an FGF21 Analog, Reduces Triglycerides and Hepatic Fat in Obese Adults With Modest Hypertriglyceridemia.
J Clin Endocrinol Metab
; 107(1): e57-e70, 2022 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34431493
2.
FGF21 Normalizes Plasma Glucose in Mouse Models of Type 1 Diabetes and Insulin Receptor Dysfunction.
Endocrinology
; 162(9)2021 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33951176
3.
New hypotheses about the structure-function of proprotein convertase subtilisin/kexin type 9: analysis of the epidermal growth factor-like repeat A docking site using WaterMap.
Proteins
; 78(12): 2571-86, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20589640
4.
Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity.
Biochem J
; 406(2): 203-7, 2007 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17608623
5.
Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models.
J Med Chem
; 60(16): 7099-7107, 2017 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28771350
6.
Discovery and Characterization of Allosteric WNK Kinase Inhibitors.
ACS Chem Biol
; 11(12): 3338-3346, 2016 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27712055
7.
Identification of 2-[2-[2-(5-bromo-2- methoxyphenyl)-ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model.
J Med Chem
; 47(7): 1602-4, 2004 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-15027849
8.
RGS domain: production and uses of recombinant protein.
Methods Enzymol
; 344: 647-57, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-11771417
9.
Pharmacological inhibition of stearoyl CoA desaturase in the skin induces atrophy of the sebaceous glands.
J Invest Dermatol
; 133(8): 2091-4, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23446987
10.
Identification and structure-activity relationships of a new series of Melanocortin-4 receptor antagonists.
Bioorg Med Chem Lett
; 16(8): 2302-5, 2006 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16458508
11.
Role of regulator of G protein signaling 16 in inflammation-induced T lymphocyte migration and activation.
J Immunol
; 171(3): 1542-55, 2003 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12874248
12.
Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease.
Blood
; 100(6): 2046-55, 2002 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12200365
13.
Synthesis and biological evaluation of imidazole-based small molecule antagonists of the melanocortin 4 receptor (MC4-R).
Bioorg Med Chem Lett
; 14(14): 3721-5, 2004 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-15203150