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1.
Environ Sci Technol ; 57(10): 4332-4341, 2023 03 14.
Artigo em Inglês | MEDLINE | ID: mdl-36857490

RESUMO

Trade causes the geospatial separation of production and consumption, which drives telecoupling between resource utilization and distant consumption. While benefiting the economy, trade can also exacerbate resource use inequality among regions. Here, we propose telecoupled water withdrawal (TWW) to examine the impact of distant consumption on local water resources, defined as local water withdrawal driven remotely by consumption in other regions. We characterize the TWW in China in 2015 at the city level (350 cities) using a nested multiregional input-output model. We find that approximately 20% of TWW is linked to foreign consumption, more than a quarter of which is driven by the United States. Moreover, cities with high TWW are concentrated on the Southeast coast and in Northwest China. Cities in Xinjiang province (Northwest China) account for 12% of the national TWW but only 0.7% of China's GDP. Our findings shed light on the telecoupling of pressure on local water resources in China cities and distant consumption at the global scale, calling for joint efforts by the contributors and beneficiaries of TWW to ensure the synergistic sustainability of water resources and trade.


Assuntos
Abastecimento de Água , Água , Cidades , Recursos Hídricos , China
2.
J Environ Manage ; 336: 117663, 2023 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-36893537

RESUMO

China is working to boost the manufacture, market share, sales, and use of NEVs to replace fuel vehicles in transportation sector to get carbon reduction target by 2060. In this research, using Simapro life cycle assessment software and Eco-invent database, the market share, carbon footprint, and life cycle analysis of fuel vehicles, NEVs, and batteries were calculated from the last five years to next 25 years, with a focus on the sustainable development. Results indicate globally, China had 293.98 m vehicles and 45.22% worldwide highest market share, followed by Germany with 224.97 m and 42.22% shares. Annually China's NEVs production rate is 50%, and sales account for 35%, while the carbon footprint will account for 5.2 E+07 to 4.89 E+07 kgCO2e by 2021-2035. The power battery production 219.7 GWh reaches 150%-163.4%, whereas carbon footprint values in production and use stage of 1 kWh of LFP 44.0 kgCO2eq, NCM-146.8 kgCO2eq, and NCA-370 kgCO2eq. The single carbon footprint of LFP is smallest at about 5.52 E+09, while NCM is highest at 1.84 E+10. Thus, using NEVs, and LFP batteries will reduce carbon emissions by 56.33%-103.14% and 56.33% or 0.64 Gt to 0.006 Gt by 2060. LCA analysis of NEVs and batteries at manufacturing and using stages quantified the environmental impact ranked from highest to lowest as ADP > AP > GWP > EP > POCP > ODP. ADP(e) and ADP(f) at manufacturing stage account for 14.7%, while other components account for 83.3% during the use stage. Conclusive findings are higher sales and use of NEVs, LFP, and reduction in coal-fired power generation from 70.92% to 50%, and increase in renewable energy sources in electricity generation expectedly will reduce carbon footprint by 31% and environmental impact on acid rain, ozone depletion, and photochemical smog. Finally, to achieve carbon neutrality in China, the NEVs industry must be supported by incentive policies, financial aid, technological improvements, and research and development. This would improve NEV's supply, demand, and environmental impact.


Assuntos
Carbono , Objetivos , Carbono/análise , Motivação , China , Pegada de Carbono , Dióxido de Carbono/análise
3.
J Clean Prod ; 361: 132291, 2022 Aug 10.
Artigo em Inglês | MEDLINE | ID: mdl-35620658

RESUMO

The sudden Coronavirus Disease reported at the end of 2019 (COVID-19) has brought huge pressure to Chinese Plug-in Electric Vehicles (PEVs) industry which is bearing heavy burden under the decreasing fiscal subsidy. If the epidemic continues to rage as the worst case, analysis based on System Dynamics Model (SDM) indicates that the whole PEVs industry in China may shrink by half compared with its originally expected level in 2035. To emerge from the recession, feasible industrial policies include (1) accelerating the construction of charging infrastructures, (2) mitigating the downtrend of financial assistance and (3) providing more traffic privilege for drivers. Extending the deadline of fiscal subsidy by only 2 years, which has been adopted by the Chinese central government, is demonstrated to achieve remarkable effect for the revival of PEVs market. By contrast, the time when providing best charging service or most traffic privilege to get the PEVs industry back to normal needs to be advanced by 10 years or earlier. For industrial policy makers, actively implementing the other two promoting measures on the basis of existing monetary support may be a more efficient strategy for Chinese PEVs market to revive from the shadow in post-COVID-19 era.

4.
J Environ Manage ; 274: 111236, 2020 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-32827870

RESUMO

Beijing benefits from the promotion of electric vehicles (EVs) in the improvement of road tailpipe emissions; these emissions are caused by internal combustion engine vehicles (ICEVs) and reduce the surrounding environmental quality. When analyzing the electricity grid, upstream emissions of EVs in Beijing can be tracked back to Shanxi and Inner Mongolia. This study investigates the inharmonious mechanism of emission reduction to promote EVs in Beijing and Northern China based on 6 scenarios and 42 real EVs. Because there is a neighbor effect, Beijing only accounts for 34%, 34%, 41%, and 35% of the total CO2, NOx, SO2 and PM2.5 emissions, respectively. Although the local CO2, NOx, and PM2.5 emissions can be easily reduced (as long as the conversion of "coal to gas" plan is realized), it is difficult to achieve emission reductions of NOx and SO2 without increasing the clean electricity generation mix in Shanxi and Inner Mongolia at the total emission level. However, there is still a large reduction potential of EVs themselves due to an increasingly clean electricity mix in Beijing, Shanxi and Inner Mongolia. Beijing local CO2, NOx, SO2 and PM2.5 emissions can be reduced by 86.92%, 98.79%, 99.98% and 99.94%, respectively, and a total reduction of 78.43% of CO2, 93.83% of NOx, 97.85% of SO2 and 99.26% of PM2.5 emissions is possible. Compared with the corresponding ICEV, an EV of 18 kWh/100 km starts to reduce Beijing local CO2, NOx and PM2.5 emissions in scenario 1, 3 and 1, respectively, while the SO2 emissions cannot be reduced. However, the total CO2, NOx, SO2 and PM2.5 emissions can be reduced in scenario 2, 5, 5, and 1, respectively. A sensitivity analysis shows that the promotion of EVs can reduce Beijing local CO2, NOx, SO2 and PM2.5 emissions by 125.568-238.960 g/km, 0.059-0.113 g/km, -0.00003 - - 0.00007 g/km and 0.034-0.065 g/km, respectively. In addition, the total CO2, NOx, SO2 and PM2.5 reduction in emissions can be 132.883-253.757 g/km, 0.189-0.361 g/km, 0.299-0.569 g/km and 0.053-0.101 g/km, respectively.


Assuntos
Poluentes Atmosféricos/análise , Poluição do Ar/análise , Poluição do Ar/prevenção & controle , Pequim , Dióxido de Carbono , China , Eletricidade , Monitoramento Ambiental , Material Particulado/análise , Emissões de Veículos/análise
5.
Med Sci Monit ; 25: 8213-8220, 2019 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-31675354

RESUMO

BACKGROUND The aim of this study was to identify the nosocomial infection (NI) risk factors in neonatal Intensive Care Units (NICU). MATERIAL AND METHODS Databases (PubMed, Embase, Cochrane, VANFUN, CNKI, and VTTMS) were searched using index words to find relevant studies published before November 2018. Meta-analyses of relative risk (RR) were performed for the identification of risk factors. RESULTS Data from 22 cohort studies (2270 infants with and 21 605 infants without NI) were included in the meta-analysis. Infant weight of <2500 g (RR: 3.44, 95% CI: 2.31-5.11), gestational age of <37 weeks (RR: 3.85, 95% CI: 1.87-7.92), mechanical ventilation use (RR: 3.16, 95% CI: 2.21-4.50), venipuncture (RR: 3.01, 95% CI: 1.20-7.57), the incidence of asphyxia (RR: 1.68, 95% CI: 1.04-2.71), and feeding intolerance (RR: 2.12, 95% CI: 1.60-2.81) were identified as the risk factors for the incidence of NI. There was no significant publication bias. CONCLUSIONS This study shows that <2500 g infant body weight, gestational age of <37 weeks, mechanical ventilation utility, venipuncture, asphyxia incidence, and feeding intolerance are the risk factors for NI nosocomial infection in infants in NICU. Appropriate preventive measures and targeted interventions are needed.


Assuntos
Infecção Hospitalar/epidemiologia , Infecção Hospitalar/etiologia , Asfixia , Peso ao Nascer , China/epidemiologia , Feminino , Idade Gestacional , Humanos , Incidência , Lactente , Recém-Nascido , Unidades de Terapia Intensiva Neonatal/tendências , Masculino , Respiração Artificial/efeitos adversos , Fatores de Risco
6.
J Wound Care ; 28(Sup4): S23-S30, 2019 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-30975063

RESUMO

OBJECTIVE: To verify the feasibility of treating pressure ulcers (PUs) with autologous platelet-rich fibrin-based (PRF) bioactive membrane, both in vitro and in vivo. METHOD: An animal model using adult male Sprague-Dawley rats was used. Pressure was periodically exerted on the skin to induce localised ischaemia by using an external magnet and transplanted metal disc. After a PU developed, the rats were divided into two groups: a treatment group and a control group. Rats in the treatment group were then treated with PRF bioactive membrane every three days. RESULTS: A total of 20 rats were used in this study. At days three and seven, the PU area in the PRF bioactive membrane-treated group was significantly smaller than that in the control group, and after 14 days of treatment, the PUs in the PRF bioactive membrane treatment group had healed. Haemotoxylin and eosin staining, immunohistochemistry and Western blot results indicated that PRF bioactive membrane induced wound healing by increasing the thickness of the regenerated epidermis and by upregulating vascular endothelial growth factor expression. Further, we found that different concentrations of rat autologous PRF soluble factors extraction components could significantly promote rat aortic endothelial cell proliferation, wound healing and migration ability in vitro. CONCLUSION: Overall, results indicate that PRF bioactive membrane promotes PU healing in rats. Thus, it may represent a natural and effective wound-healing tool for use in the treatment of clinical skin PUs in humans in the future.


Assuntos
Plaquetas/metabolismo , Proliferação de Células/efeitos dos fármacos , Fibrina Rica em Plaquetas , Úlcera por Pressão/terapia , Cicatrização/fisiologia , Animais , Masculino , Modelos Animais , Ratos , Ratos Sprague-Dawley
7.
Sci Total Environ ; 953: 176045, 2024 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-39241891

RESUMO

Food system is the main consumer of water resources, and the differences in urban and rural diets pose new challenges to the water sustainability and increase the uncertainty of food security in China. In this study, we quantified the dietary water footprint (DWF) of urban and rural residents at the city scale in four major urban agglomerations in China from 2015 to 2021, identified the key economic and educational factors of urban and rural DWF, and measured the inequality of urban and rural DWF driven by the main influencing factors. We found that there was a 27.17 % increase in urban DWF and a 23.18 % increase in rural DWF between 2015 and 2021. Cereals had the largest water footprint among the 12 food types, accounting for 20.27 % and 31.57 % of urban and rural DWF, respectively. Meanwhile, milk and dairy products contributed the most to the difference between urban and rural DWF, up to 57.89 m3 each year. The main economic factor of DWF was consumption expenditure. The number of primary school students and the number of primary schools are the most important educational factors of urban and rural DWF, respectively. The results show there is an inequality between DWF and major educational factors, with a decreasing trend in DWF inequality over time. This study revealed for the first time the difference between urban and rural DWF at the city scale, and clarified the impact of regional educational inequality on DWF. A greater focus should be placed on the primary education-related factors that influence DWF inequality, in order to better target sustainable DWF strategies for urban and rural residents.


Assuntos
População Rural , População Urbana , China , População Rural/estatística & dados numéricos , População Urbana/estatística & dados numéricos , Humanos , Dieta/estatística & dados numéricos , Fatores Socioeconômicos , Abastecimento de Água/estatística & dados numéricos , Abastecimento de Alimentos/estatística & dados numéricos , Cidades
8.
BMJ Open ; 14(8): e082518, 2024 Aug 17.
Artigo em Inglês | MEDLINE | ID: mdl-39153796

RESUMO

INTRODUCTION: Haemodialysis (HD) patients usually engage in a low level of physical activities, which could impact the prognosis and mortality of this group. Fitness Qigong Baduanjin, a physical exercise from traditional Chinese Medicine, is known to have benefit in chronic heart failure patients and peritoneal dialysis patients. However, researches about Baduanjin in HD patients are currently limited. So, the aim of the study is to investigate the current exercise intensity of HD patients and its influencing factors, and to explore the effects of Baduanjin on HD patients. METHODS AND ANALYSIS: This prospective, non-blinded, randomised controlled trial will enrol patients with end-stage kidney disease who were stable on HD for more than 3 months. All eligible participants will be randomly divided into the intervention group undergoing Baduanjin and the control group without Baduanjin in a 1:1 ratio. The intervention group is required to perform Baduanjin two times per day, starting 30 min after breakfast and dinner, 45 min per session for a total of a 6 month, starting from 10 June 2024. Information such as laboratory biochemical examination indicators, radiological examination results and related scales and questionnaires will be collected at baseline, 1 month follow-up, 3 month follow-up and 6 month follow-up. All statistical tests are conducted through the two-tailed test, and a p-value≤0.05 will be considered statistically significant for the difference being tested. The description of quantitative indicators will be used in calculating the number of cases, mean, SD, median and IQR method. The classification indicators will be used to describe the number of cases and percentages (frequency and frequency rate). ETHICS AND DISSEMINATION: The study protocol was approved by the Ethics Committee of the First Affiliated Hospital of Zhejiang Chinese Medical University (V20230521). The results will be reported in a peer-reviewed journal and a relevant academic conference. TRAIL REGISTRATION: ChiCTR2300074659.


Assuntos
Falência Renal Crônica , Estado Nutricional , Qigong , Qualidade de Vida , Diálise Renal , Humanos , Qigong/métodos , Estudos Prospectivos , Falência Renal Crônica/terapia , Ensaios Clínicos Controlados Aleatórios como Assunto , Adulto , Feminino , Pessoa de Meia-Idade , Masculino
9.
ScientificWorldJournal ; 2013: 824078, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24191144

RESUMO

The conflict of water environment protection and economic development has brought severe water pollution and restricted the sustainable development in the watershed. A risk explicit interval linear programming (REILP) method was used to solve integrated watershed environmental-economic optimization problem. Interval linear programming (ILP) and REILP models for uncertainty-based environmental economic optimization at the watershed scale were developed for the management of Lake Fuxian watershed, China. Scenario analysis was introduced into model solution process to ensure the practicality and operability of optimization schemes. Decision makers' preferences for risk levels can be expressed through inputting different discrete aspiration level values into the REILP model in three periods under two scenarios. Through balancing the optimal system returns and corresponding system risks, decision makers can develop an efficient industrial restructuring scheme based directly on the window of "low risk and high return efficiency" in the trade-off curve. The representative schemes at the turning points of two scenarios were interpreted and compared to identify a preferable planning alternative, which has the relatively low risks and nearly maximum benefits. This study provides new insights and proposes a tool, which was REILP, for decision makers to develop an effectively environmental economic optimization scheme in integrated watershed management.


Assuntos
Conservação dos Recursos Naturais/métodos , Desenvolvimento Econômico , Modelos Teóricos , Programação Linear , Poluição da Água/prevenção & controle , Agricultura , Criação de Animais Domésticos , Animais , China , Humanos , Indústrias , Lagos , Viagem , Qualidade da Água
10.
Sci Total Environ ; 867: 161577, 2023 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-36638997

RESUMO

Crop production is the main consumer of water resources. The heterogeneous water resource endowments and imbalanced crop water use exacerbate regional resource consumption inequality. In this study, we quantified the crop water footprint (CWF) of 356 cities in China from 2000 to 2020, measured the inequality between the city CWF and water resources, and identified different strategies to alleviate regional CWF inequality. We found that the average CWF from 2000 to 2020 varied widely across cities, ranging from 0.03 × 108 m3 to 806.78 × 108 m3, and the inequality between city CWF and local water resource endowment was increasing. China had a strong dependence on green water in crop production, and its proportion increased from 52.48 % to 67.17 %. The Gini coefficient of the green water footprint increased from 0.545 to 0.621, and the degree of inequality increased significantly. In addition, the blue water and gray water continuously showed great inequality, especially the blue water, the Gini coefficient of which was 0.724 in 2020. The results show significant disparities in CWF among cities, which have highly exacerbated regional inequality in China. Improving the utilization rate of green water is an important measure to balance the allocation between serving the natural ecosystem and meeting the basic human needs. This study revealed for the first time the inequality of city-level CWF and highlights the severe situation of inequality among regions in China. Balancing the inequality between CWF and water resource endowment at city-level is conducive to fundamentally solving the problem of unreasonable water resource allocation.

11.
Sci Rep ; 13(1): 7952, 2023 May 16.
Artigo em Inglês | MEDLINE | ID: mdl-37193809

RESUMO

As an important part of electric vehicles, lithium-ion battery packs will have a certain environmental impact in the use stage. To analyze the comprehensive environmental impact, 11 lithium-ion battery packs composed of different materials were selected as the research object. By introducing the life cycle assessment method and entropy weight method to quantify environmental load, a multilevel index evaluation system was established based on environmental battery characteristics. The results show that the Li-S battery is the cleanest battery in the use stage. In addition, in terms of power structure, when battery packs are used in China, the carbon footprint, ecological footprint, acidification potential, eutrophication potential, human toxicity cancer and human toxicity noncancer are much higher than those in the other four regions. Although the current power structure in China is not conducive to the sustainable development of electric vehicles, the optimization of the power structure is expected to make electric vehicles achieve clean driving in China.

12.
Sci Total Environ ; 806(Pt 4): 151484, 2022 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-34742807

RESUMO

Planetary boundaries define the safe operating space of human beings relative to the Earth's system, which is of great significance in helping human beings predict environmental safety limits. However, ecological boundaries have not been presented or downscaled to regional levels. Moreover, a method has not been developed to quantitatively measure the gap between the value of the services provided by the ecosystem and the size of the urban population and economy that the ecosystem can carry. Herein, we propose the concept and calculation model of the "ecological boundary" to quantitatively assess the ecosystem security gap size transgressed by humans. Ecological boundaries are defined as the maximum population and economic scale that a certain area can support under a certain ecologically productive area. The purpose of this paper is to investigate the ecological boundary in megacities, and Beijing is considered as a specific case. The results show that the consumption of natural resources has transgressed its ecological boundary in Beijing. The direct consequence is that the ecological well-being per capita continues to decrease. Fortunately, with decreases in the ecological footprint and land use/land cover change dynamic degree, the ecological boundary gap is gradually tightening. Moreover, the role of ecological boundaries as early warning signals of undesirable urban ecological environmental changes is discussed, the significance of the monetization of ecological boundaries is described, the factors underlying the ecological boundary gap in the process of accelerating urbanization in China are analyzed, and policy recommendations for resolving the threat to ecological security boundaries by megacities are presented. The primary purpose of our study is provide policymakers with information on the gap between the current well-being of humankind and critical capacity thresholds, which can help determine whether human activities have fallen into an unsustainable state that may result in undesirable eco-environmental changes that could have detrimental or even disastrous consequences for the population of a region.


Assuntos
Conservação dos Recursos Naturais , Ecossistema , Pequim , China , Cidades , Ecologia , Humanos
13.
Environ Monit Assess ; 157(1-4): 29-42, 2009 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-18704726

RESUMO

A tiered approach consisting of several probabilistic options was used to refine aquatic ecological risk assessment (ERA) of individuals and mixture of various Organochlorine Pesticides (OCPs) detected in Jiangsu reach of Huaihe River, China. The tiered approach ranged from determined Hazard Quotient (HQ) to Joint Probability Curve and Monte Carlo simulation based HQ-distribution. The results from all levels of ERA methods in the tiered framework are consistent with each other. The results show that Endrin, o,p'-Dichloro-Diphenyl-Trichloroethane (DDT), alpha-Endosulfan and beta-Endosulfan posed clear ecological risk; p,p'-DDT, p,p'-DDD, Aldrin, Heptachlorepoxide and Methoxychlor posed potential risk; while Hexachlorocyclohexanes, Heptachlor, Dieldrin and Hexachlorobenzene posed negligible risk. Further, based on the concept of total equivalent concentration, combined ecological risk caused by the mixture of all detected OCPs was calculated, and it proved to be significantly higher than the risk caused by any individual OCP. Despite inevitable uncertainties in current ERA, a comprehensive tiered approach can help to get a more credible result of risks of individuals and mixture of hazardous pollutants and screen the major risk pollutants contributing to the combined ecological risk.


Assuntos
Monitoramento Ambiental/métodos , Hidrocarbonetos Clorados/análise , Praguicidas/análise , Rios/química , Poluentes Químicos da Água/análise , China , DDT/análise , DDT/toxicidade , Diclorodifenildicloroetano/análise , Diclorodifenildicloroetano/toxicidade , Hidrocarbonetos Clorados/toxicidade , Praguicidas/toxicidade , Medição de Risco , Poluentes Químicos da Água/toxicidade
14.
Environ Sci Pollut Res Int ; 26(36): 36538-36557, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31732947

RESUMO

As secondary batteries are becoming the popular production of industry, especial for lithium ion batteries (LIBs), the degree of environmental friendliness will gather increasing attention to their products of the whole life cycle. The research combines the life cycle assessment (LCA) and footprint family definition to establish a framework to calculate the footprint family of secondary battery materials. Through the method, we calculated the values of carbon footprint, water footprint, and ecological footprint about this eight kinds of secondary cathode battery materials with Ni-MH, Li1.2Ni0.2Mn0.6O2/C, LiNi1/3Co1/3Mn1/3O2/C, LiNi0.8Co0.2O2/C, LiFePO4/C, LiFe0.98Mn0.02PO4/C, FeF3(H2O)3/C, and NaFePO4/C. When comparing and analyzing their values in each footprint, it can summarize the evaluation method for some secondary batteries by footprint indicators and construct the evaluation system. Through the comprehensive evaluation of footprint family system, the NaFePO4/C battery gets the best performance of three main footprints when combining 1 kg of cathode materials, while Ni-MH is opposite. Hence, among these eight batteries environmental impacts evaluation, the NaFePO4/C battery is regarded as the superior "green" battery, albeit the current application is restricted because of the synthesis limitation on large scale and energy density of storage. In LIBs comparison, the FeF3(H2O)3 material shows its characteristics of environmental friendliness, which is expected to be a greener battery material of LIB. In conventional LIBs, the iron-containing cathode materials show lower environmental burden than ternary cathode materials. We can reduce environmental impacts through developing new advanced materials and reducing the content of high sensitivity element in raw materials.


Assuntos
Fontes de Energia Elétrica/normas , Poluição Ambiental , Lítio , Modelos Teóricos , Algoritmos , Eletrodos , Poluição Ambiental/análise , Poluição Ambiental/prevenção & controle , Química Verde , Íons
15.
Am J Transl Res ; 11(9): 6040-6054, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31632572

RESUMO

Cyclooxygenase-2 (COX2) and tumor-associated macrophages (TAMs) are associated with invasion, angiogenesis, and poor prognosis in many human cancers. However, the role of TAMs in human gastric cancer (GC) remains elusive. In the present study, we first measured COX2 expression and TAM infiltration in human GC tissues using double immunohistochemical staining. Then, we indirectly cocultured M2-polarized macrophages derived from human THP-1 cells with GC cells as an in vitro model. Transwell assays, siRNA transfection, treatment with a COX2 inhibitor and Western blotting were used to investigate the relationship among TAMs, invasion and COX2 expression as well as the underlying molecular mechanism. Double IHC staining showed that TAMs were aggregated near GC tumor nests and had high COX2 expression; moreover, the number of TAMs that infiltrated the tumor nest was correlated with the depth of invasion, COX2 expression and poor prognosis in human GC. In an in vitro assay, after treatment with phorbol myristate acetate (PMA), the THP-1 cells differentiated into M2 macrophages and induced COX2/MMP9-dependent invasiveness in GC cells. Pretreatment of GC cells with COX2 siRNA or a COX2 inhibitor (Celecoxib) can negate these promoting effects. The results of this study and those of our previous studies indicate that coculture with M2-polarized macrophages can induce the COX2-dependent release of matrix metalloproteinase-9 (MMP9), which subsequently increases the invasiveness of GC cells. Our data may provide a basis for targeting TAMs or for polarizing TAMs through immune regulation to halt GC progression, which could soon become a nonsurgical treatment for human gastric cancer.

16.
J Environ Sci (China) ; 20(4): 505-12, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-18575139

RESUMO

This article presents the application of an integrated method that estimates the dispersion of polycyclic aromatic hydrocarbons (PAHs) in air, and assesses the human health risk associated with PAHs inhalation. An uncertainty analysis method consisting of three components were applied in this study, where the three components include a bootstrapping method for analyzing the whole process associated uncertainty, an inhalation rate (IR) representation for evaluating the total PAH inhalation risk for human health, and a normally distributed absorption fraction (AF) ranging from 0% to 100% to represent the absorption capability of PAHs in human body. Using this method, an integrated process was employed to assess the health risk of the residents in Beijing, China, from inhaling PAHs in the air. The results indicate that the ambient air PAHs in Beijing is an important contributor to human health impairment, although over 68% of residents seem to be safe from daily PAH carcinogenic inhalation. In general, the accumulated daily inhalation amount is relatively higher for male and children at 10 years old of age than for female and children at 6 years old. In 1997, about 1.73% cancer sufferers in Beijing were more or less related to ambient air PAHs inhalation. At 95% confidence interval, approximately 272-309 individual cancer incidences can be attributed to PAHs pollution in the air. The probability of greater than 500 cancer occurrence is 15.3%. While the inhalation of ambient air PAHs was shown to be an important factor responsible for higher cancer occurrence in Beijing, while the contribution might not be the most significant one.


Assuntos
Poluentes Atmosféricos , Compostos Policíclicos/administração & dosagem , Incerteza , Administração por Inalação , China , Humanos , Medição de Risco
17.
ACS Appl Mater Interfaces ; 10(38): 32058-32066, 2018 Sep 26.
Artigo em Inglês | MEDLINE | ID: mdl-30141898

RESUMO

Recently, lithium oxygen battery has become a promising candidate to satisfy the current large-energy-storage devices demand because of its amazing theoretical energy density. However, it still faces problems such as poor reversibility and short cycle life. Here, citrus maxima peel (CMP) was used as a precursor to prepare activated and Fe-loading carbon (CMPACs and CMPACs-Fe, respectively) via pyrolysis in nitrogen atmosphere at 900 °C, in which KOH was added as an activator. Electrochemical measurements show that CMPAC-based Li-O2 battery possesses high specific capacity of 7800 mA h/g, steady cycling performance of 466 cycles with a corresponding Coulombic efficiency of 92.5%, good rate capability, and reversibility. Besides, CMPACs-Fe-based O2 electrode delivers even lower overpotential in both charge and discharge processes. We conclude that these excellent electrochemical performances of CMPACs and CMPACs-Fe-based O2 electrode benefit from their cellular porous structure, plenty of active sites, and large specific surface area (900 and 768 m2/g), which suggest that these biomass-derived porous carbons might become promising candidates to achieve efficient lithium oxygen battery.

18.
Sci Total Environ ; 637-638: 1051-1060, 2018 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-29801201

RESUMO

Individual footprint indicators are limited in that they usually only address one specific environmental aspect. For this reason, assessments involving multiple footprint indicators are preferred. However, the interpretation of a profile of footprint indicators can be difficult as the relative importance of the different footprint results is not readily discerned by decision-makers. In this study, a time series (1997-2012) of carbon, water and land footprints was calculated for industry sectors in the Beijing region using input-output analysis. An integrated environmental footprint (IEF) was subsequently developed using normalization and entropy weighting. The results show that steep increases in environmental footprint have accompanied Beijing's rapid economic development. In 2012, the Primary Industry had the largest IEF (8.32); however, the Secondary Industry had the greatest increase over the study period, from 0.19 to 6.37. For the Primary Industry, the greatest contribution to the IEF came from the land footprint. For the Secondary and Tertiary Industries, the water footprint was most important. Using the IEF, industry sectors with low resource utilization efficiency and high greenhouse gas emissions intensity can be identified. As such, the IEF can help to inform about industry sectors which should be given priority for modernization as well as the particular footprints that require priority attention in each sector. The IEF can also be helpful in identifying industry sectors that could be encouraged to expand within the Beijing region as they are especially efficient in terms of value adding relative to IEF. Other industries, over time, may be better located in other regions that do not face the same environmental pressures as Beijing.

19.
Chin J Integr Med ; 24(11): 809-814, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-29946873

RESUMO

OBJECTIVE: To explore the preventive effect of applying hot compress with Chinese herbal salt packets (CHSP) to puncture vessels under aseptic conditions during peripherally inserted central catheter (PICC) on postoperative phlebitis. METHODS: A total of 720 hospitalized patients undergoing first PICC were assigned to treatment and control groups (360 cases each group) according to a random number table. The control group received conventional catheterization and nursing care. The treatment group was first given hot compress with CHSP (which consisted of honeysuckle 30 g, Semen brassicae 30 g, Salvia miltiorrhiza 30 g, Angelica dahurica 30 g, Semen raphani 30 g, Evodia rutaecarpa 30 g, and coarse salt 20 g) on the punctured vessel under aseptic conditions for 5-10 min before conventional catheterization. The main efficacy indices were the vessel diameters before and during catheterization and the success rate of a single catheter, and the secondary efficacy indiex was the incidence of superficial phlebitis within 1 week after catheterization. RESULTS: The vessel diameter during catheterization of the treatment group was remarkably increased compared with the control group [(7.96±0.42) mm vs. (4.39±0.54) mm, P<0.01]. The success rate of the single catheter of the treatment group was significantly higher than that of the control group [94.00% (329/350) vs. 73.72% (244/329), P<0.01]. The incidence of superficial phlebitis within 1 week after catheterization in the treatment group was lower than that in the control group (P=0.007). There was no adverse event with CHSP. CONCLUSION: Hot compress with CHSP during PICC is applicable as it can effectively improve the success rate of a single catheter and reduce the incidence of superficial phlebitis after catheterization (Trial registration No. ChiCTR-ONC-17010498).


Assuntos
Cateterismo Periférico/efeitos adversos , Cateteres Venosos Centrais/efeitos adversos , Medicamentos de Ervas Chinesas/administração & dosagem , Flebite/prevenção & controle , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
20.
Environ Sci Pollut Res Int ; 24(2): 1251-1260, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-27770328

RESUMO

A promising Li-rich high-capacity cathode material (xLi2MnO3·(1-x)LiMn0.5Ni0.5O2) has received much attention with regard to improving the performance of lithium-ion batteries in electric vehicles. This study presents an environmental impact evaluation of a lithium-ion battery with Li-rich materials used in an electric vehicle throughout the life cycle of the battery. A comparison between this cathode material and a Li-ion cathode material containing cobalt was compiled in this study. The battery use stage was found to play a large role in the total environmental impact and high greenhouse gas emissions. During battery production, cathode material manufacturing has the highest environmental impact due to its complex processing and variety of raw materials. Compared to the cathode with cobalt, the Li-rich material generates fewer impacts in terms of human health and ecosystem quality. Through the life cycle assessment (LCA) results and sensitivity analysis, we found that the electricity mix and energy efficiency significantly influence the environmental impacts of both battery production and battery use. This paper also provides a detailed life cycle inventory, including firsthand data on lithium-ion batteries with Li-rich cathode materials.


Assuntos
Fontes de Energia Elétrica , Meio Ambiente , Lítio/farmacologia , Automóveis , Cobalto , Eletrodos , Humanos , Íons
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