Detalhe da pesquisa
1.
TATDN2 resolution of R-loops is required for survival of BRCA1-mutant cancer cells.
Nucleic Acids Res
; 51(22): 12224-12241, 2023 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37953292
2.
Total synthesis/semi-synthesis of natural isopentenyl flavonoids with inhibitory activity on NLRP3 inflammasome.
Bioorg Med Chem Lett
; 107: 129777, 2024 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38692522
3.
DyScore: A Boosting Scoring Method with Dynamic Properties for Identifying True Binders and Nonbinders in Structure-Based Drug Discovery.
J Chem Inf Model
; 62(22): 5550-5567, 2022 11 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36327102
4.
In Silico Observation of the Conformational Opening of the Glutathione-Binding Site of Microsomal Prostaglandin E2 Synthase-1.
J Chem Inf Model
; 59(9): 3839-3845, 2019 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31429562
5.
Design, synthesis, and discovery of 5-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones and related derivatives as novel inhibitors of mPGES-1.
Bioorg Med Chem Lett
; 28(5): 858-862, 2018 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29456107
6.
Selective inhibitors of human mPGES-1 from structure-based computational screening.
Bioorg Med Chem Lett
; 27(16): 3739-3743, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28689972
7.
HIV-1 transgenic rats display an increase in [(3)H]dopamine uptake in the prefrontal cortex and striatum.
J Neurovirol
; 22(3): 282-92, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26501780
8.
Par-4 secretion: stoichiometry of 3-arylquinoline binding to vimentin.
Org Biomol Chem
; 14(1): 74-84, 2016 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26548370
9.
Halogenated diarylacetylenes repress c-myc expression in cancer cells.
Bioorg Med Chem Lett
; 24(15): 3638-40, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24930834
10.
De novo design of multitarget ligands with an iterative fragment-growing strategy.
J Chem Inf Model
; 54(4): 1235-41, 2014 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-24611712
11.
Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL.
Nat Commun
; 15(1): 2743, 2024 Mar 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38548768
12.
Piperlongumine conjugates induce targeted protein degradation.
Cell Chem Biol
; 30(2): 203-213.e17, 2023 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36750097
13.
Synthesis-accessibility-oriented design of c-Jun N-terminal kinase 1 inhibitor.
Eur J Med Chem
; 256: 115442, 2023 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37156184
14.
PELP1 inhibition by SMIP34 reduces endometrial cancer progression via attenuation of ribosomal biogenesis.
Mol Oncol
; 2023 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37853941
15.
Mutations of tyrosine 467 in the human norepinephrine transporter attenuate HIV-1 Tat-induced inhibition of dopamine transport while retaining physiological function.
PLoS One
; 17(9): e0275182, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36170295
16.
Replenishing HDL with synthetic HDL has multiple protective effects against sepsis in mice.
Sci Signal
; 15(725): eabl9322, 2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35290084
17.
A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER+ Breast Cancer.
Cancer Res
; 82(20): 3830-3844, 2022 10 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35950923
18.
LigBuilder 2: a practical de novo drug design approach.
J Chem Inf Model
; 51(5): 1083-91, 2011 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-21513346
19.
Multiple Target Drug Design Using LigBuilder 3.
Methods Mol Biol
; 2266: 279-298, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33759133
20.
Binding Mode of Human Norepinephrine Transporter Interacting with HIV-1 Tat.
ACS Chem Neurosci
; 12(9): 1519-1527, 2021 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33886267