Integrative analysis of a novel super-enhancer-associated lncRNA prognostic signature and identifying LINC00945 in aggravating glioma progression.

BACKGROUND: Super-enhancers (SEs), driving high-level expression of genes with tumor-promoting functions, have been investigated recently. However, the roles of super-enhancer-associated lncRNAs (SE-lncRNAs) in tumors remain undetermined, especially in gliomas. We here established a SE-lncRNAs expression-based prognostic signature to choose the effective treatment of glioma and identify a novel therapeutic target. METHODS: Combined analysis of RNA sequencing (RNA-seq) data and ChIP sequencing (ChIP-seq) data of glioma patient-derived glioma stem cells (GSCs) screened SE-lncRNAs. Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) datasets served to construct and validate SE-lncRNA prognostic signature. The immune profiles and potential immuno- and chemotherapies response prediction value of the signature were also explored. Moreover, we verified the epigenetic activation mechanism of LINC00945 via the ChIP assay, and its effect on glioma was determined by performing the functional assay and a mouse xenograft model. RESULTS: 6 SE-lncRNAs were obtained and identified three subgroups of glioma patients with different prognostic and clinical features. A risk signature was further constructed and demonstrated to be an independent prognostic factor. The high-risk group exhibited an immunosuppressive microenvironment and was higher enrichment of M2 macrophage, regulatory T cells (Tregs), and Cancer-associated fibroblasts (CAFs). Patients in the high-risk group were better candidates for immunotherapy and chemotherapeutics. The SE of LINC00945 was further verified via ChIP assay. Mechanistically, BRD4 may mediate epigenetic activation of LINC00945. Additionally, overexpression of LINC00945 promoted glioma cell proliferation, EMT, migration, and invasion in vitro and xenograft tumor formation in vivo. CONCLUSION: Our study constructed the first prognostic SE-lncRNA signature with the ability to optimize the choice of patients receiving immuno- and chemotherapies and provided a potential therapeutic target for glioma.

Observation of the possible magnetic correction above the Curie temperature in Cr2Si2Te6 single crystals.

Intrinsic magnetic semiconductors hold great promise in the fields of fundamental magnetization and spintronics. One such semiconductor is Cr2Si2Ti6 (CST), a quasi two-dimensional (2D) magnetic semiconductor with potential applications in future magnetic devices. However, the origin of ferromagnetism in CST remains a mystery. To investigate this, ac/dc susceptibility and electronic spin resonance (ESR) measurements were conducted. Based on ac susceptibility scaling, the critical temperature (TC) for the ferromagnetic (FM) to paramagnetic (PM) phase transition was found to be ∼32.5 K, with a critical exponent of δ = 6.7 from the critical isotherm, ß + γ = 1.72 from the temperature dependence of the crossover line, and γ = 1.43 from the temperature dependence of susceptibility along the same line. All critical exponents were found to be consistent with the dc magnetization scaling method. However, above and below TC, the origin of magnetism cannot be explained by a single theory. To explore the origin of abnormal magnetic critical behavior, ESR measurements were performed. Below T* ∼ 130 K, the ESR measurements revealed that the resonance field width (ΔH) tends to increase and decrease for the applied magnetic field H parallel and perpendicular to the c axis, respectively, indicating the onset of magnetic interaction even in the PM state. Meanwhile, the deviation from Curie-Weiss behavior below T* also confirmed the occurrence of magnetic correlation above the TC in CST. These observations suggest that the competition and cooperation among the direct and indirect interactions, the structural distortion and the van der Waals interaction at high temperature should be considered to investigate the origin of anomalous magnetism in CST. The present results provide valuable insights into the nature of ferromagnetism in 2D magnetic semiconductors.

Identification of an endoplasmic reticulum stress-related signature associated with clinical prognosis and immune therapy in glioma.

BACKGROUND: Glioma is the most common brain tumor in adults and is characterized by a short survival time and high resistance to chemotherapy. It is imperative to determine the prognosis and therapy-related targets for glioma. Endoplasmic reticulum stress (ERS), as an adaptive protective mechanism, indicates the unfolded protein response (UPR) to determine cell survival and affects chemotherapy sensitivity, which is related to the prognosis of glioma. METHODS: Our research used the TCGA database as the training group and the CGGA database as the testing group. Lasso regression and Cox analysis were performed to construct an ERS signature-based risk score model in glioma. Three methods (time-dependent receiver operating characteristic analysis and multivariate and univariate Cox regression analysis) were applied to assess the independent prognostic effect of texture parameters. Consensus clustering was used to classify the two clusters. In addition, functional and immune analyses were performed to assess the malignant process and immune microenvironment. Immunotherapy and anticancer drug response prediction were adopted to evaluate immune checkpoint and chemotherapy sensitivity. RESULTS: The results revealed that the 7-gene signature strongly predicts glioma prognosis. The two clusters have markedly distinct molecular and prognostic features. The validation group result revealed that the signature has exceptional repeatability and certainty. Functional analysis showed that the ERS-related gene signature was closely associated with the malignant process and prognosis of tumors. Immune analysis indicated that the ERS-related gene signature is strongly related to immune infiltration. Immunotherapy and anticancer drug response prediction indicated that the ERS-related gene signature is positively correlated with immune checkpoint and chemotherapy sensitivity. CONCLUSIONS: Collectively, the ERS-related risk model can provide a novel signature to predict glioma prognosis and treatment.

Strain-induced spin-gapless semiconductors and pure thermal spin-current in magnetic black arsenic-phosphorus monolayers.

Spin-gapless semiconductor (SGS) materials are regarded as the most promising candidates for ideal massless and dissipationless states towards low-power spintronic device applications. Here, we propose a spin-gapless semiconducting black arsenic-phosphorus (AsP) monolayer halogenated by chlorine (Cl) adatoms and reveal the perfect spin Seebeck effect induced by its SGS character to produce pure thermal spin-current using first-principles calculations. Our results show that Cl atoms prefer to adsorb P atoms rather than As atoms in the AsP monolayer, behaving as a ferromagnetic semiconductor. The As-adsorbed AsP monolayer as an ideal SGS material with parabolic-type energy dispersion can be utilized to realize symmetrical spin Seebeck current for perfect pure thermal spin-current even at an extremely low on-off temperature. Moreover, in-plane strain engineering can effectively manipulate the electronic structures of the P-absorbed AsP monolayer for perfect parabolic-type SGS similar to As-adsorbed AsP, and to obtain the relevant thermoelectric effect. These distinct features suggest the potential applications of the Cl-halogenated AsP monolayer with the SGS character in low-power spin-caloritronic devices.

Large refractive index modulation based on a BDK-doped step-index PMMA optical fiber for highly reflective Bragg grating inscription.

We experimentally report high reflectivity on the poly(methyl methacrylate) (PMMA)-based polymer optical fiber Bragg gratings by means of a 266 nm pulsed laser and phase mask technique. In the first recipe, fiber Bragg gratings (FBGs) were manufactured with a single pulse up to 3.7 mJ. After post-annealing, a stable refractive index change up to 4.2×10-4 was obtained. In the second recipe, FBGs were inscribed by 22 pulses with a lower pulse energy of 1.4 mJ, showing a stable refractive index change of 6.2×10-4. Both behaviors may mainly be attributed to the movement of initiating radicals arising from benzyl dimethyl ketal (BDK) under UV irradiation. The high refractive index change in step-index fibers paves the way to tilted FBG manufacturing with large tilt angles potentially for biomedical applications.

Humidity-Sensitive PMMA Fiber Bragg Grating Sensor Probe for Soil Temperature and Moisture Measurement Based on Its Intrinsic Water Affinity.

Soil moisture measurement is very important for soil system monitoring. Compared to the traditional thermo-gravimetric technique, which is time-consuming and can be only performed in labs, the optic-fiber technique has unique advantages, such as small size, remote application in fields, fast response time and immunity to electromagnetic fields. In this paper, the soil moisture is measured by using a polymer optical fiber Bragg grating (POFBG) probe with a packaged dimension of 40 mm × 15 mm × 8 mm. Due to the intrinsic water-absorbing property of poly (methyl methacrylate) (PMMA), optical fiber Bragg gratings based on PMMA have been widely investigated for humidity measurement. Taking advantage of this, a sensor based on the POFBG is investigated to verify the soil condition. The POFBG is protectively integrated inside a stainless-steel package. A window is opened with a thin polypropylene mat as a filter, which allows the air to go through but prevents the soil from going inside to pollute the POFBG. The sensor probe is embedded in soils with different gravimetric soil moisture contents (SMCs) ranging from 0% to 40% and, then, insulated by polyethylene films to minimize the impact from the external environment, showing an average temperature cross sensitivity of -0.080 nm/°C. For a constant temperature, an exponential relationship between the Bragg wavelength and the SMC is obtained. For the SMCs between 8% and 24%, linear relationships are presented showing a temperature-corresponded sensitivity between 0.011 nm/% and 0.018 nm/%. The maximal sensitivity is calculated to be 0.018 nm/% at 20 °C, which is 28 times as high as that in the previous work. For the SMC over 24%, the sensor becomes insensitive because of humidity saturation in the cavity of the sensor probe. Though temperature cross sensitivity is problematic for SMC measurement, the influence could be eliminated by integrating another humidity-insensitive temperature sensor, such as a silica FBG temperature sensor.

Polycarbonate mPOF-Based Mach-Zehnder Interferometer for Temperature and Strain Measurement.

In this paper, an endlessly single mode microstructured polymer optical fiber (mPOF) in a Mach-Zehnder (M-Z) interferometer configuration is demonstrated for temperature and strain measurement. Because there is no commercial splicer applied for POF-silica optical fiber (SOF) connectorization, prior to the M-Z interferometric sensing, we introduce an imaging projecting method to align a polycarbonate mPOF to a SOF and then the splice is cured permanently using ultraviolet (UV) glue. A He-Ne laser beam at 632.8 nm coupled in a SOF is divided by a 1 × 2 fiber coupler to propagate in two fiber arms. A piece of mPOF is inserted in one arm for sensing implementation and the interference fringes are monitored by a camera. For non-annealed fiber, the temperature sensitivity is found to be 25.5 fringes/°C for increasing temperature and 20.6 fringes/°C for decreasing temperature. The converted sensitivity per unit length is 135.6 fringes/°C/m for increasing temperature, which is twice as much as the silica fiber, or 852.2 rad/°C/m (optical phase change versus fiber temperature), which is more than four times as much as that for the PMMA fiber. To solve the sensitivity disagreement, the fiber was annealed at 125 °C for 36 h. Just after the thermal treatment, the temperature measurement was conducted with sensitivities of 16.8 fringes/°C and 21.3 fringes/°C for increasing and decreasing process, respectively. One month after annealing, the linear response was improved showing a temperature sensitivity of ~20.7 fringes/°C in forward and reverse temperature measurement. For the strain measurement based on non-annealed fiber, the sensitivity was found to be ~1463 fringes/%ε showing repeatable linear response for forward and reverse strain. The fiber axial force sensitivity was calculated to be ~2886 fringes/N, showing a force measurement resolution of ~3.47 × 10-4 N. The sensing methodology adopted in this work shows several advantages, such as very low cost, high sensitivity, a straightforward sensing mechanism, and ease of fabrication.

Structure and 3/7-like Magnetization Plateau of Layered Y2Cu7(TeO3)6Cl6(OH)2 Containing Diamond Chains and Trimers.

We have synthesized a new spin-1/2 antiferromagnet, Y2Cu7(TeO3)6Cl6(OH)2, via a traditional hydrothermal method. This compound crystallizes in the triclinic crystal system with space group P1̅. The magnetic ions constitute a two-dimensional layered lattice with a novel topological structure in which the Cu4 clusters make up distorted diamond chains along the a axis and these chains are connected by the Cu3 trimers. The magnetic susceptibility and specific heat measurements show that the compound is antiferromagnetically ordered at TN = 4.1 K. This antiferromagnetic ordering is further supported by electron spin resonance (ESR) data. The magnetization curve presents a field-induced metamagnetic transition at 0.2 T, followed by a magnetization plateau within a wide magnetic field range from 7 T to at least 55 T, which corresponds to 3/7 of the saturated magnetization with g = 2.15 obtained from ESR. The possible mechanism for the magnetization plateau is discussed.

Syntheses, Structure, and 2/5 Magnetization Plateau of a 2D Layered Fluorophosphate Na3Cu5(PO4)4F·4H2O.

A new two-dimensional (2D) fluorophosphate compound Na3Cu5(PO4)4F·4H2O with a Cu5 cluster has been synthesized using a conventional hydrothermal method. The compound crystallizes in the orthorhombic crystal system with space group Pnma. The 2D layered structure is formed by cap-like {Cu5(PO4)4F} building units consisting of a Cu4O12F cluster plus a residual cap Cu2+ ion. Magnetic susceptibility exhibits a broad maximum at T2 = 19.2 K due to low-dimensional character followed by a long-range antiferromagnetic ordering at T1 = 11.5 K, which is further confirmed by the specific heat data. High-field magnetization measurement demonstrates a 2/5 quantum magnetization plateau above 40 T. The ESR data indicate the presence of magnetic anisotropy, in accordance with the 2D structure of the system.

Mononuclear or Dinuclear? Mechanistic Study of the Zinc-Catalyzed Oxidative Coupling of Aldehydes and Acetylenes.

Although zinc catalysis is widely used in organic synthesis, very few studies on the dinuclear zinc mechanism have been reported. Here, a dinuclear zinc pathway is proposed for the Zn(OTf)2 -catalyzed oxidative coupling of aldehydes with terminal alkynes. DFT calculations revealed that the deprotonation of the terminal alkyne would preferentially lead to the formation of a dinuclear zinc intermediate. The nucleophilic addition of this intermediate to an aldehyde, followed by an Oppenauer-type oxidation was investigated theoretically according to the mono- and dinuclear pathways. The formation of a dinuclear zinc intermediate from a mononuclear alkynyl zinc complex was exergonic, favoring the dinuclear zinc pathway. The subsequent protonation and regeneration of the active dinuclear catalyst were also evaluated by DFT calculations. The oxidizabilities of various aldehydes and ketones were evaluated to determine the best oxidant for this step. Trifluoroacetaldehyde was predicted to be a better oxidant for this reaction because its calculated energy barrier for the Oppenauer-type oxidation step was much lower than that of the other carbonyl complexes.

Bamboo-like carbon nanotube/Fe3C nanoparticle hybrids and their highly efficient catalysis for oxygen reduction.

The design of a new class of non-noble-metal catalysts with oxygen reduction reaction (ORR) activity superior to that of Pt is extremely important for future fuel cell devices. Here we demonstrate a one-pot, large-scale protocol for the controlled synthesis of new one-dimensional bamboo-like carbon nanotube/Fe(3)C nanoparticle hybrid nanoelectrocatalysts, which are directly prepared by annealing a mixture of PEG-PPG-PEG Pluronic P123, melamine, and Fe(NO(3))(3) at 800 °C in N(2). The resulting hybrid electrocatalysts show very high ORR activity with a half-wave potential of 0.861 V (vs reversible hydrogen electrode) in 0.10 M KOH solution, 49 mV more positive than that of 20 wt% Pt/C catalyst. Furthermore, they exhibit good ORR activity in acidic media, with an onset potential comparable to that of the Pt/C catalyst. Most importantly, they show much higher stability and better methanol tolerance, with almost no ORR polarization curve shift and no change of the oxygen reduction peak in the cyclic voltammogram in the presence of 1.0 M methanol, than those of the commercial Pt/C catalyst in both alkaline and acidic solutions. This makes them one of the best non-noble-metal catalysts ever reported for ORR in both alkaline and acidic solutions.

Swimtrans Net: a multimodal robotic system for swimming action recognition driven via Swin-Transformer.

Introduction: Currently, using machine learning methods for precise analysis and improvement of swimming techniques holds significant research value and application prospects. The existing machine learning methods have improved the accuracy of action recognition to some extent. However, they still face several challenges such as insufficient data feature extraction, limited model generalization ability, and poor real-time performance. Methods: To address these issues, this paper proposes an innovative approach called Swimtrans Net: A multimodal robotic system for swimming action recognition driven via Swin-Transformer. By leveraging the powerful visual data feature extraction capabilities of Swin-Transformer, Swimtrans Net effectively extracts swimming image information. Additionally, to meet the requirements of multimodal tasks, we integrate the CLIP model into the system. Swin-Transformer serves as the image encoder for CLIP, and through fine-tuning the CLIP model, it becomes capable of understanding and interpreting swimming action data, learning relevant features and patterns associated with swimming. Finally, we introduce transfer learning for pre-training to reduce training time and lower computational resources, thereby providing real-time feedback to swimmers. Results and discussion: Experimental results show that Swimtrans Net has achieved a 2.94% improvement over the current state-of-the-art methods in swimming motion analysis and prediction, making significant progress. This study introduces an innovative machine learning method that can help coaches and swimmers better understand and improve swimming techniques, ultimately improving swimming performance.

Cervical cancer incidence, mortality, and burden in China: a time-trend analysis and comparison with England and India based on the global burden of disease study 2019.

Background: Cervical cancer is the fourth highest incidence of malignancy in the world and a common cause of cancer death in women. We assessed the trends of incidence and mortality and disability-adjusted life year (DALY) in China, England and India from 1990 to 2030. Method: Data were obtained from the Global Burden of Disease (GBD) database. We collected the number and rate of incidence, death and DALY from 1990 to 2019 and calculated the estimated annual percentage change (EAPC). Further analysis was carried out by ages and years. We also collected attributable risk factors to cervical cancer. Finally, we utilized the Bayesian Age-Period-Cohort (BAPC) model to forecast trends in the rate of age-standardized incidence (ASIR) and age-standardized death (ASDR) the for the next decade. Result: Globally, the incidence of cervical cancer cases increased from 335,641.56 in 1990 to 565,540.89 in 2019. In 2019, the ASIR and ASDR of cervical cancer were higher than those of India but lower than those of England. Furthermore, unsafe sex and smoking emerge as prominent risk factors for cervical cancer. Over the next decade, ASIR and ASDR are expected to decline in China and England, while India's ASIR is still on an upward trend and ASDR is on a downward trend. Conclusion: The epidemiological data of cervical cancer in these three countries reflects the influence of different stages of development and healthcare systems. Trends over the next decade suggest that China and India still face a huge burden of cervical cancer. When England has made significant progress, China and India need to take more measures to improve the prevention and control of cervical cancer.

Taraxacum mongolicum polysaccharide promotes white adipocyte browning by regulating miR-134-3p via Akt/GSK-3ß signalling.

In recent years, the incidence of obesity has gradually increased due to high calorie diets and lack of exercise. Reducing energy intake or increasing energy expenditure is the most effective way to promote weight loss and reduce lipid levels. Activated beige adipocytes can increase energy consumption in the body, and inducing conversion of white adipocytes to brown can prevent and treat obesity. Taraxacum mongolicum polysaccharide (TMP) is a plant polysaccharide that has been widely used for its anti-tumour and antioxidant properties. However, little is known about the role of TMP in the browning of sheep white adipose tissue. The aim of this study was to explore the potential mechanism of TMP and miR-134-3p in regulating the browning of sheep white adipocytes, as well as the regulatory relationship between TMP and miR-134-3p. Our results showed that TMP had a positive regulatory effect on the proliferation and browning of sheep white adipocytes. In addition, miR-134-3p significantly inhibited browning activity and AKT/GSK-3ß signalling. Importantly, we found that TMP function required miR-134-3p mediation in the browning of sheep white adipocytes. Overall, our results suggested that TMP recruited beige adipocytes by regulating AKT/GSK-3ß signalling via miR-134-3p.

In Defense of Clip-Based Video Relation Detection.

Video Visual Relation Detection (VidVRD) aims to detect visual relationship triplets in videos using spatial bounding boxes and temporal boundaries. Existing VidVRD methods can be broadly categorized into bottom-up and top-down paradigms, depending on their approach to classifying relations. Bottom-up methods follow a clip-based approach where they classify relations of short clip tubelet pairs and then merge them into long video relations. On the other hand, top-down methods directly classify long video tubelet pairs. While recent video-based methods utilizing video tubelets have shown promising results, we argue that the effective modeling of spatial and temporal context plays a more significant role than the choice between clip tubelets and video tubelets. This motivates us to revisit the clip-based paradigm and explore the key success factors in VidVRD. In this paper, we propose a Hierarchical Context Model (HCM) that enriches the object-based spatial context and relation-based temporal context based on clips. We demonstrate that using clip tubelets can achieve superior performance compared to most video-based methods. Additionally, using clip tubelets offers more flexibility in model designs and helps alleviate the limitations associated with video tubelets, such as the challenging long-term object tracking problem and the loss of temporal information in long-term tubelet feature compression. Extensive experiments conducted on two challenging VidVRD benchmarks validate that our HCM achieves a new state-of-the-art performance, highlighting the effectiveness of incorporating advanced spatial and temporal context modeling within the clip-based paradigm.

Genome-Wide Identification of Specific Genetic Loci Common to Sheep and Goat.

Sheep and goat may become carriers of some zoonotic diseases. They are important livestock and experimental model animals for human beings. The fast and accurate identification of genetic materials originating from sheep and goat can prevent and inhibit the spread of some zoonotic diseases, monitor market product quality, and maintain the stability of animal husbandry and food industries. This study proposed a methodology for identifying sheep and goat common specific sites from a genome-wide perspective. A total of 150 specific sites were selected from three data sources, including the coding sequences of single copy genes from nine species (sheep, goat, cow, pig, dog, horse, human, mouse, and chicken), the dbSNPs for these species, and human 100-way alignment data. These 150 sites exhibited low intraspecific heterogeneity in the resequencing data of 1450 samples from five species (sheep, goat, cow, pig, and chicken) and high interspecific divergence in the human 100-way alignment data after quality control. The results were proven to be reliable at the data level. Using the process proposed in this study, specific sites of other species can be screened, and genome-level species identification can be performed using the screened sites.

Taraxacum Mongolicum Polysaccharides Reverses Mice Obesity via Activation of AKT/mTOR Pathway.

BACKGROUND/OBJECTIVES: The global prevalence of obesity and its associated health complications represent significant public health concerns. Plant polysaccharides have been demonstrated to possess a range of beneficial pharmacological effects. This experiment was designed to elucidate the mechanisms of dietary Taraxacum mongolicum polysaccharides involved in the regulation of obesity and fat browning. METHODS: Male C57BL/6J mice were randomly divided into three groups: a control group, a high-fat diet (HFD) group, and an HFD group supplemented with 0.3% TMPs. The mice were fed their respective diets for 10 weeks, after which their body weight, food consumption, and serum lipid levels were measured. Histological analysis was performed to assess lipid deposition in adipose tissue and liver. Western blot was used to assess the expression of proteins involved in the AKT/mTOR pathway. RESULTS: The results show that compared with the HFD group, the TMP supplementation group's body-weight gain (12.17 ± 1.77) significantly decreased. TMPs also reduced serum levels of total cholesterol, triglycerides, and low-density lipoprotein cholesterol. Histological analysis showed that TMPs reduced lipid deposition in both adipose tissue and the liver. CONCLUSIONS: In addition, TMPs increased the expression of phosphorylated AKT and the mechanistic target of rapamycin (mTOR), indicating that TMPs exert their beneficial effects on lipid metabolism via the AKT/mTOR pathway.

A dominant missense variant within LMBR1 related to equine polydactyly.

Polydactyly was recorded before 100 BCE and attracted widespread interest because of its relationship to limb health and ancestral traits in horses. However, the underlying reasons for the development of polydactyly remain unclear. To search for polydactyly-related genes, we utilize a paternal half-sib family and screen for variants that match the mode of inheritance. Through this screening process, 77 variants in 65 genes are filtered. A missense variant (EqCab3.0 chr4: <107353368> A > G) (rs1138485164) in the 3rd exon of LMBR1 is identified as a source of amino acid sequence variation. Gene editing confirms that the variant down-regulates LMBR1expression, increases the proliferative viability of mutant cells, and inhibits apoptosis. This study suggests that LMBR1 might play a role in the development of polydactyly and that the variant detected in this study is related to polydactyly in horses. However, further research is needed to determine whether a direct relationship exists.

Anomalous Hall effect and magnetic transition in the kagome material YbMn6Sn6.

We investigate the magnetic and transport properties of a kagome magnet YbMn6Sn6. We have grown YbMn6Sn6single crystals having a HfFe6Ge6type structure with ordered Yb and Sn atoms, which is different from the distorted structure previously reported. The single crystal undergoes a ferromagnetic phase transition around 300 K and a ferrimagnetic transition at approximately 30 K, and the magnetic transition at low temperature may be correlated to the ordered Yb sublattice. Negative magnetoresistance has been observed at high temperatures, while the positive magnetoresistance appears at 5 K when the current is oriented out of kagome plane. We observe a large anisotropic anomalous Hall effect with the intrinsic Hall contribution of 141 Ω-1cm-1forσzxintand 32 Ω-1cm-1forσxyint, respectively. These values are similar to those in YMn6Sn6with the same anisotropy. The magnetic transition and anomalous Hall behavior in YbMn6Sn6highlights the influence of the ordered Yb atoms and rare earth elements on its magnetic and transport properties.

Extremely Large Anomalous Hall Conductivity and Unusual Axial Diamagnetism in a Quasi-1D Dirac Material La3MgBi5.

Anomalous Hall effect (AHE), one of the most important electronic transport phenomena, generally appears in ferromagnetic materials but is rare in materials without magnetic elements. Here, a study of La3MgBi5 is presented, whose band structure carries multitype Dirac fermions. Although magnetic elements are absent in La3MgBi5, the signals of AHE can be observed. In particular, the anomalous Hall conductivity is extremely large, reaching 42,356 Ω-1 cm-1 with an anomalous Hall angle of 8.8%, the largest one that has been observed in the current AHE systems. The AHE is suggested to originate from the combination of skew scattering and Berry curvature. Another unique property discovered in La3MgBi5 is the axial diamagnetism. The diamagnetism is significantly enhanced and dominates the magnetization in the axial directions, which is the result of the restricted motion of the Dirac fermion at the Fermi level. These findings not only establish La3MgBi5 as a suitable platform to study AHE and quantum transport but also indicate the great potential of 315-type Bi-based materials for exploring novel physical properties.