Detalhe da pesquisa
1.
Small-Scale Panel Comprising Diverse Gene Family Targets To Evaluate Compound Promiscuity.
Chem Res Toxicol
; 33(1): 154-161, 2020 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31461269
2.
Discovery of orally efficacious RORγt inverse agonists. Part 2: Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives.
Bioorg Med Chem
; 26(2): 470-482, 2018 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29258712
3.
Practical application of 3-substituted-2,6-difluoropyridines in drug discovery: Facile synthesis of novel protein kinase C theta inhibitors.
Bioorg Med Chem Lett
; 27(11): 2497-2501, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28400232
4.
Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors-Part 2.
Bioorg Med Chem
; 24(14): 3207-17, 2016 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27255177
5.
Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors - Part 3.
Bioorg Med Chem
; 24(16): 3716-26, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27325446
6.
Design, synthesis and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitor.
Bioorg Med Chem
; 23(15): 5000-5014, 2015 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26051602
7.
Assessment of a 3D neural spheroid model to detect pharmaceutical-induced neurotoxicity.
ALTEX
; 39(4): 560-582, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35502629
8.
Cell-based high-throughput screening for the evaluation of reactive metabolite formation potential.
Toxicol In Vitro
; 74: 105159, 2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-33823239
9.
Utility of Physicochemical Properties for the Prediction of Toxicological Outcomes: Takeda Perspective.
ACS Med Chem Lett
; 11(2): 203-209, 2020 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32071689
10.
New phenotypic cytotoxicity assay for ROS-inducing compounds using rat renal epithelial cells.
Toxicol Lett
; 331: 227-234, 2020 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32522578
11.
Freshly isolated primary human proximal tubule cells as an in vitro model for the detection of renal tubular toxicity.
Toxicology
; 442: 152535, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32622972
12.
Nickel-catalyzed carbocyanation of alkynes with allyl cyanides.
J Am Chem Soc
; 131(31): 10964-73, 2009 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-19722672
13.
Nickel/AlMe(2)Cl-catalysed carbocyanation of alkynes using arylacetonitriles.
Chem Commun (Camb)
; (26): 3931-3, 2009 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19662256
14.
Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor γt (RORγt) Agonist Structure-Based Functionality Switching Approach from In House RORγt Inverse Agonist to RORγt Agonist.
J Med Chem
; 62(3): 1167-1179, 2019 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30652849
15.
Discovery of [ cis-3-({(5 R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1 H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5 H)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist.
J Med Chem
; 61(7): 2973-2988, 2018 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29510038
16.
Allylcyanation of alkynes: regio- and stereoselective access to functionalized di- or trisubstituted acrylonitriles.
J Am Chem Soc
; 128(22): 7116-7, 2006 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-16734437
17.
Stannylative cycloaddition of enynes catalyzed by palladium-iminophosphine.
J Am Chem Soc
; 126(48): 15650-1, 2004 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-15571380