Detalhe da pesquisa
1.
Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists.
Bioorg Med Chem Lett
; 25(6): 1196-205, 2015 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25686852
2.
Discovery of nonbenzamidine factor VIIa inhibitors using a biaryl acid scaffold.
Bioorg Med Chem Lett
; 23(18): 5239-43, 2013 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23927973
3.
Discovery of SY-5609: A Selective, Noncovalent Inhibitor of CDK7.
J Med Chem
; 65(2): 1458-1480, 2022 01 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34726887
4.
7-Oxopyrrolopyridine-derived DPP4 inhibitors-mitigation of CYP and hERG liabilities via introduction of polar functionalities in the active site.
Bioorg Med Chem Lett
; 21(22): 6646-51, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21996520
5.
Synthesis and SAR of azolopyrimidines as potent and selective dipeptidyl peptidase-4 (DPP4) inhibitors for type 2 diabetes.
Bioorg Med Chem Lett
; 20(15): 4395-8, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20598534
6.
Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.
Bioorg Med Chem Lett
; 19(5): 1451-6, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19201606
7.
(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1h-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (BMS-644950): a rationally designed orally efficacious 3-hydroxy-3-methylglutaryl coenzyme-a reductase inhibitor with reduced myotoxicity potential.
J Med Chem
; 51(9): 2722-33, 2008 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-18412317
8.
Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.
J Med Chem
; 51(5): 1145-9, 2008 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18260618
9.
Design, synthesis, and structure-activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARalpha/gamma agonists.
Bioorg Med Chem Lett
; 18(12): 3545-50, 2008 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18511276
10.
Discovery of azetidinone acids as conformationally-constrained dual PPARalpha/gamma agonists.
Bioorg Med Chem Lett
; 18(6): 1939-44, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18291645
11.
Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
Bioorg Med Chem Lett
; 18(11): 3168-72, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18485702
12.
Discovery of potent and muscle selective androgen receptor modulators through scaffold modifications.
J Med Chem
; 50(13): 3015-25, 2007 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17552509
13.
Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors.
Bioorg Med Chem Lett
; 17(23): 6476-80, 2007 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17937986
14.
Bioanalysis of Pseudomonas aeruginosa alkyl quinolone signalling molecules in infected mouse tissue using LC-MS/MS; and its application to a pharmacodynamic evaluation of MvfR inhibition.
J Pharm Biomed Anal
; 139: 44-53, 2017 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-28273650
15.
Polypharmacology Approaches against the Pseudomonas aeruginosa MvfR Regulon and Their Application in Blocking Virulence and Antibiotic Tolerance.
ACS Chem Biol
; 12(5): 1435-1443, 2017 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28379691
16.
Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist.
ACS Med Chem Lett
; 7(6): 590-4, 2016 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27326332
17.
Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics.
J Med Chem
; 48(1): 171-9, 2005 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-15634011
18.
Optimization of activity, selectivity, and liability profiles in 5-oxopyrrolopyridine DPP4 inhibitors leading to clinical candidate (Sa)-2-(3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)-N,N-dimethylacetamide (BMS-767778).
J Med Chem
; 56(18): 7343-57, 2013 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-23964740
19.
Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors.
J Med Chem
; 53(15): 5620-8, 2010 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-20684603
20.
Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).
J Med Chem
; 53(7): 2854-64, 2010 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-20218621