Detalhe da pesquisa
1.
Somatic and intergenerational G4C2 hexanucleotide repeat instability in a human C9orf72 knock-in mouse model.
Nucleic Acids Res
; 2024 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38597682
2.
Germline Mutations in CIDEB and Protection against Liver Disease.
N Engl J Med
; 387(4): 332-344, 2022 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35939579
3.
CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis.
N Engl J Med
; 385(6): 493-502, 2021 08 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34215024
4.
NMIHBA results from hypomorphic PRUNE1 variants that lack short-chain exopolyphosphatase activity.
Hum Mol Genet
; 29(21): 3516-3531, 2021 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33105479
5.
Humanized C3 Mouse: A Novel Accelerated Model of C3 Glomerulopathy.
J Am Soc Nephrol
; 32(1): 99-114, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33288630
6.
A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease.
N Engl J Med
; 378(12): 1096-1106, 2018 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29562163
7.
Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity.
Proc Natl Acad Sci U S A
; 115(32): E7642-E7649, 2018 08 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30038024
8.
Multifunctional Alleles: A novel method for the generation of "All-In-One" null and conditional alleles.
Methods
; 164-165: 91-99, 2019 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31039396
9.
LX2761, a Sodium/Glucose Cotransporter 1 Inhibitor Restricted to the Intestine, Improves Glycemic Control in Mice.
J Pharmacol Exp Ther
; 362(1): 85-97, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28442582
10.
Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation.
Am J Physiol Gastrointest Liver Physiol
; 309(6): G455-65, 2015 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26206858
11.
Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine.
Gut
; 63(6): 928-37, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23749550
12.
Effect of LX4211 on glucose homeostasis and body composition in preclinical models.
J Pharmacol Exp Ther
; 350(2): 232-42, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24849925
13.
Improved glycemic control in mice lacking Sglt1 and Sglt2.
Am J Physiol Endocrinol Metab
; 304(2): E117-30, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23149623
14.
LX4211 increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporter 1 (SGLT1)-mediated absorption of intestinal glucose.
J Pharmacol Exp Ther
; 345(2): 250-9, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23487174
15.
The knockout mouse project.
Nat Genet
; 36(9): 921-4, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15340423
16.
Production of large, defined genome modifications in rats by targeting rat embryonic stem cells.
Stem Cell Reports
; 18(1): 394-409, 2023 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36525967
17.
IL-6-GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models.
Sci Adv
; 9(15): eadf4490, 2023 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37058568
18.
Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency.
Sci Transl Med
; 15(723): eadd4897, 2023 11 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37992152
19.
The tryptophan hydroxylase inhibitor LX1031 shows clinical benefit in patients with nonconstipating irritable bowel syndrome.
Gastroenterology
; 141(2): 507-16, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21684281
20.
Homozygous ALS-linked FUS P525L mutations cell- autonomously perturb transcriptome profile and chemoreceptor signaling in human iPSC microglia.
Stem Cell Reports
; 17(3): 678-692, 2022 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35120624