[Aetiology of childhood alopecia]. / Caracterización de las causas de alopecia infantil.

INTRODUCTION: Childhood alopecia is a relative rare event in general paediatric dermatology practice. Hair loss in children may have multiple causes, and there are different types of alopecia according to age groups. The aim of the study was to describe the clinical and epidemiological profile of alopecia in children from two Chilean paediatric hospitals. PATIENTS AND METHOD: Descriptive analysis of clinical records of patients from the Dermatology Department of Roberto del Rio and Luis Calvo Mackenna Hospitals between January 2007 and June 2010. Patients with clinical diagnosis of alopecia were included. RESULTS: A total of 345 clinical records were analysed, with 179 males (51.9%). The median age was 72 months. Overall, the most common diagnoses were: alopecia areata (AA), (36.8%), tinea capitis (TC), (21%), nevus sebaceous (13.2%), and tellogen effluvium (8.7%). According to age groups, in newborns, the most common causes were aplasia cutis and nevus sebaceous. In toddlers, pre-school and school children, the principal causes were nevus sebaceous, AA and TC. Trichotillomania was also significant in school children. In adolescents, nevus sebaceous, AA and tellogen effluvium were the most frequent diagnoses. AA was statistically associated with autoimmune disease, thyroid disease, nail disorder, psychiatric disease, and Down's syndrome. The most common aetiological agent in TC was M. canis (86.6%). Trichotillomania was also statistically associated to psychiatric disorders. CONCLUSIONS: In this study, the main causes of alopecia in children were acquired and non-scarring alopecia. In our results, the type of alopecia varies according to age group. Some types of childhood alopecia showed a close correlation to psychiatric disorders.

Patología dermatológica facial asociada al uso de la mascarilla durante la pandemia causada por el virus Sars-CoV-2 / Facial dermatological pathology associated with use of the mask during the pandemic caused by the Sars-CoV-2 virus

The use of facemask has become a key element to prevent the infection of Covid-19. Its prolonged use, both, by health personnel and the general population, has caused the appearance of multiple adverse effects at the facial level; highlighting the report of symptoms such as discomfort with the mask, facial itching, redness, erythema, among others. The appearance of dermatological diseases such as acne, allergic and irritative contact dermatitis, and exacerbation of pre-existing pathologies such as acne, rosacea and seborrheic dermatitis are also frequent. Knowledge of these complications is important for their prevention and proper management. (AU)

Efluvio telógeno y Covid-19 / Telogen effluvium and Covid-19

The first case of infection by the virus SARS-CoV-2 was reported in China in the late 2019. The disease caused by this virus was called COVID-19 and was declared as a global pandemic by World Health Organization in March 2020. Among the consequences caused by the virus, some dermatological pathologies have been reported, such as Telogen effluvium (TE). In this review we will address the relation between Telogen effluvium and COVID-19. Material and methods: All literature related to Telogen effluvium and COVID-19 was searched in PubMed. Results: Since the beginning of the pandemic, the number of patients diagnosed with TE has increased. This is explained on one hand by the infection itself of the virus, generating a proinflammatory and procoagulant answer that lead to TE. On the other hand, it can be explained due to the stress caused by the lockdowns and the psychological consequences of a global pandemic. Also, the therapies used to treat the infection may increase the severity of the TE. The relation between TE and Covid-19 is not totally clear yet, but it is important due to the great impact that generates in the lives of the patients. (AU)

Obesidad y piel / Obesity and skin

Introduction: Obesity is a growing global health problem; it may even be one of the worst public health issues. In Chile, 34.4% of the population is obese, therefore, is it important for clinicians to be aware of all the consequences of obesity. In this review, we will address the relation of four main dermatologic conditions with obesity: psoriasis, hidradenitis suppurativa, acanthosis nigricans and malignant melanoma. Material and methods: Search in pubmed for obesity and psoriasis, hidradenitis suppurativa, acanthosis nigricans and malignant melanoma. Results: Obesity has a direct impact in the prevalence and severity of psoriasis, hidradenitis suppurativa, acanthosis nigricans. The reduction on body weight has proven to reduce severity of psoriasis and hidradenitis suppurativa. Obese patients with psoriasis have a higher risk on adverse effects due to medication and less effectiveness of biological medications. Acanthosis nigricans is a clinical indicator of insulin resistance and a risk predictor for those with greater risk to develop diabetes in the future. The relationship between obesity and malignant melanoma is not clear and needs further research. Conclusion: Obesity is increasing, dermatologist will face this condition more frequently, it has a great impact over psoriasis, hidradenitis suppurativa, acanthosis nigricans and malignant melanoma, thus it should be considered in treatment decisions. (AU)

Sarcoidosis subcutánea sin compromiso sistématico / Subcutaneous sarcoidosis without compromise systemic

We present the case of a 52 year old woman with a history of bilateral ovarian cancer operated. The patient attended the dermatology unit for a sudden onset of a left plantar nodule of three weeks of evolution, painful on walking, with no other history in particular. At physical examination, the patient presented a surface nodule slightly hyperpigmented, with ill-defined edges, round shape, firm consistency, mobile and painful to compression, one cm of diameter, in the middle third of the left plant. No concomitant scars are seen. Doppler soft tissue ultrasound is requested, showing a granulomatous nodule on the surface of the plantar aponeurosis. The biopsy lesion revealed non-caseating granulomas in cell tissue, PAS and Ziehl-Neelsen staining are negative A left plantar subcutaneous sarcoidosis is diagnosed, systemic involvement is ruled out. Within the first year of follow-up, there are no new lesions or findings compatible with systemic disease. (AU)

Conocimiento y actitud frente a exposición solar del personal de salud en Atención Primaria, comuna Recoleta, Santiago, Chile / Knowledge and attitude regardings sun exposure in the workers from primary health care, district of Recoleta, Santiago, Chile

Skin cancer rates have increased worldwide despite the current prevention measures. It’s crucial to evaluate people’s knowledge, attitudes, and behaviour regarding sun exposure. Objective: To assess the knowledge and attitudes regarding sun exposure in the workers from primary health care. Method: 223 workers from three Family Care Centres(CESFAM) and from one Primary Emergency Service (SAPU) in the district of Recoleta were surveyed between the months of October and November 2015. Fisher’s exact test and Chi square test were used for statistic analysis. The survey included questions about demographic variables, knowledge of the association between sun radiation/skin cancer and attitudes towards sun protection. Results: the sample consists of 74 men and 149 women, with a mean age of 37 years ±SD 7.9. Phototype III was the most common (41.3percent). The majority of the surveyed declared to be aware of the association between sun exposure and skin cancer (93.3percent). As photoprotecting measures, sunscreens (87.4percent) and seeking shade (71.3percent) were the most frequently measures used. Regarding sunburns, 91.9percent declared to have at least one during their lifetime, 21.5percent occurring during the previous summer. As to the use of sunscreen, 42.1percent referred only using while at the pool / beach and 12.6percent declared not to use it at all. As for health promotion, 29.1percent declared they never recommend the use of sun protection measures in their working practice. Discussion: Although there is adequate knowledge regarding the effects of sun exposure, it doesn’t always reflect on favourable attitudes and photoprotecting measures. There was a significantly greater amount of females with adequate knowledge and use of sun protection measures. This study is one of the first to assess photoprotection behaviour in health care workers.

Caracterización de pacientes pediátricos usuarios de fototerapia en el Servicio de Dermatología, Hospital Clínico Universidad de Chile (2007-2015) / Characterization of pediatrics patients users of phototherapy in dermatology service, Hospital Clínico Universidad Chile (2007-2015)

Phototherapy is the use of specific wavelenghts of light that have shown effectiveness in the treatment of several cutaneous diseases. Current indications for phototherapy in Dermatology include multiple pathologies and it is considered to be costeffective. Literature about its use in children is rare, there are no studies on phototherapy in Chilean children. Patients and methods: Observational, descriptive, retrospective study. Clinical records of pediatric patients treated with phototherapy at University of Chile Clinical Hospital between 2007 and 2015, were studied. For each patient, the following parameters were analyzed: age of starting treatment, sex, skin phenotype, diagnosis, prescribed phototherapy and weekly frecuency. Results: 146 patients, 85 girls and 51 boys, average age 11.7 +/- 4.0 years. Predominant skin phenotype, was Fitzpatrick type III. Vitiligo was identified as the most common indication for phototherapy (52,2 percent), followed by psoriasis (22,6 percent). By a large margin, the most used type of phototherapy was nb UVB (96.6 percent). Most of the patients were treated twice per week (69.2 percent). Discussion: The obtained results in this group are similar to those results described in the international literature. Further studies are required for a better knowledge about efficacy and possible long-term effects of phototherapy on Chilean children.

Caracterización de las causas de alopecia infantil / Aetiology of childhood alopecia

Introducción: La alopecia infantil es una afección poco frecuente en la consulta dermatológica pediátrica. Su etiología es variable según el grupo etario estudiado. El objetivo fue estudiar la causa de alopecia en niños en 2 hospitales pediátricos de referencia nacional en Chile. Pacientes y método: Análisis descriptivo de registros clínicos del total de pacientes atendidos entre enero de 2007 y junio de 2010 en los Servicios de Dermatología de los Hospitales Roberto del Río y Luis Calvo Mackenna. Se incluyeron pacientes con diagnóstico clínico de alopecia. Resultados: Se encontraron 345 registros clínicos, 179 varones (51,9%). La mediana de edad fue 72 meses. Los diagnósticos más prevalentes fueron alopecia areata (AA) (36,8%), tiña capitis (TC) (21%), nevo sebáceo (13,2%) y efluvio telógeno (8,7%). Según el grupo etario predominaron en recién nacidos: aplasia cutis y nevo sebáceo; en lactantes, preescolares y escolares: nevo sebáceo, AA y TC. En escolares se agregó tricotilomanía. En adolescentes nevo sebáceo, AA y efluvio telógeno. Se observó una correlación significativa entre AA con enfermedad autoinmune, enfermedad tiroidea, alteraciones ungueales, enfermedad psiquiátrica y síndrome de Down. En TC el agente etiológico más prevalente fue Microsporum Canis (86,6%). La tricotilomanía se correlacionó con enfermedad psiquiátrica significativamente. Conclusiones: Las principales causas de alopecia infantil fueron adquiridas y no cicatriciales. La etiología varía de acuerdo al grupo etario estudiado. Algunos tipos de alopecia infantil presentaron alta prevalencia de enfermedad psiquiátrica.

Introduction: Childhood alopecia is a relative rare event in general paediatric dermatology practice. Hair loss in children may have multiple causes, and there are different types of alopecia according to age groups. The aim of the study was to describe the clinical and epidemiological profile of alopecia in children from two Chilean paediatric hospitals. Patients and method: Descriptive analysis of clinical records of patients from the Dermatology Department of Roberto del Rio and Luis Calvo Mackenna Hospitals between January 2007 and June 2010. Patients with clinical diagnosis of alopecia were included. Results: A total of 345 clinical records were analysed, with 179 males (51.9%). The median age was 72 months. Overall, the most common diagnoses were: alopecia areata (AA), (36.8%), tinea capitis (TC), (21%), nevus sebaceous (13.2%), and tellogen effluvium (8.7%). According to age groups, in newborns, the most common causes were aplasia cutis and nevus sebaceous. In toddlers, pre-school and school children, the principal causes were nevus sebaceous, AA and TC. Trichotillomania was also significant in school children. In adolescents, nevus sebaceous, AA and tellogen effluvium were the most frequent diagnoses. AA was statistically associated with autoimmune disease, thyroid disease, nail disorder, psychiatric disease, and Down's syndrome. The most common aetiological agent in TC was M. canis (86.6%). Trichotillomania was also statistically associated to psychiatric disorders. Conclusions: In this study, the main causes of alopecia in children were acquired and non-scarring alopecia. In our results, the type of alopecia varies according to age group. Some types of childhood alopecia showed a close correlation to psychiatric disorders.

Melanoma Maligno acral en Chile: análisis clínico e histopatológicode 70 casos en la población consultante de hospitales públicos en Santiago, Chile / Acral malignant melanoma in Chile: clinical and histopathological analysis of 70 cases in Santiago, Chile

En este trabajo se analizan las características clínico patológicas del MM Acral en población consultante de hospitales públicos, en los períodos 1992-2001 y 2005-2009. La muestra contó con 70 casos, de los cuales 51.4 por ciento correspondió a sexo femenino, la edad promedio de la muestra fue 66,6 años. Casi la totalidad de los MM acrales fueron de planta de pies (97.1 por ciento). Los diagnósticos de derivación, fueron MM en el 78.6 por ciento, seguido por otros diagnósticos (17.1 por ciento). El tipo clínico más frecuente fue melanoma nodular (31.4 por ciento). El tipo histológico más frecuente fue el melanoma invasivo (62.9 por ciento). El índice de Breslow más frecuente fue > 1.7 mm en el 52.9 por ciento. Este estudio es uno de los primeros sobre MM acral en población chilena, con resultados similares a lo publicado en la literatura internacional, sin embargo, destaca una edad promedio de diagnóstico más tardía y un porcentaje no menor de derivación con otro diagnóstico.

In this study we analyze the clinical and histopathological profile of acral MM in the population attending at state hospitals, during the periods (1992-2001) and (2005-2009). We analyzed 70 cases of acral MM, 51.4 percent were females, with average age of 66.6 years old. The majority of acral MM were located in soles (97.1 percent). The main clinical diagnosis was malignant melanoma (78.6 percent); however, a 17.1 percent of acral MM showed a different clinical diagnosis. The main clinical type of MM was Nodular Melanoma (31.4 percent). The most frequent histopathological type was invasive melanoma (62.9 percent). The most frequent Breslow thickness was > 1.7 mm (52,9 percent). This study is one of the first analyses of acral MM in the Chilean population, with similar results to the observed in the international literature; however, our patients presented an older average age of diagnosis and showed an important percentage of clinical diagnosis different to Malignant Melanoma.

Manifestaciones cutáneas en pacientes con Enfermedad de Parkinson en una población chilena / Cutaneous manifestations in patients with Parkinson's disease In a Chilean population

IINTRODUCCIÓN: Las alteraciones cutáneas asociadas a la Enfermedad de Parkinson (EP) constituyen un área poco estudiada. OBJETIVOS: Describir las alteraciones cutáneas de un grupo de pacientes con EP y su asociación a parámetros cutáneos funcionales (sebo y humedad). PACIENTES Y MÉTODOS: Estudio observacional descriptivo prospectivo de pacientes con EP evaluados entre los meses de febrero y octubre del 2010. RESULTADOS: Se observó dermatitis seborreica (DS) en un 9,58 por ciento, no correlacionándose con seborrea (p=0,415), tiempo de evolución (p=0,338) ni severidad de la EP (p=0,787). Además, se observó un 6.84 por ciento de cáncer de piel no melanoma. La sebometría se asoció de forma inversa con la edad y mayores dosis de L-dopa. La higrometría no se asoció con tiempo de evolución, severidad de la EP ni fluctuaciones motoras. CONCLUSIONES: Los pacientes con EP evaluados tienen una mayor frecuencia de cáncer de piel no melanoma y DS, sin embargo, se necesitan más estudios para determinar su real asociación.

INTRODUCTION: Skin disorders associated with Parkinson’s disease (PD) are a poorly studied area. OBJECTIVES: To describe skin changes in a group of PD patients and its association with cutaneous functional parameters (sebum and humidity). PATIENTS AND METHODS: Descriptive prospective observational study of PD patients evaluated between February and October 2010. RESULTS: Seborrheic dermatitis (SD) was observed in 9.58 percent and not correlated with seborrhea (p = 0.415), duration (p = 0.338) and severity of PD (p = 0.787). In addition, a 6.84 percent of non-melanoma skin cancer was observed. Sebometry was inversely associated with age and higher doses of L-dopa. Humidity was not associated with time of evolution, severity of PD or motor fluctuations. CONCLUSIONS: The evaluated patients with PD have a higher frequency of non-melanoma skin cancer and SD. However, more studies are needed to establish their real association.

Consulta dermatológica geriátrica: comparación epidemiológica entre tres centros de salud / Geriatric dermatological consultation: epidemiological comparison between three health centers

El envejecimiento de la población es un fenómeno a nivel mundial, conllevando a una merma progresiva de todas las funciones de la piel. Involucra una alta prevalencia de patologías como xerosis, prurito, infecciones y neoplasias. Este estudio busca establecer las patologías dermatológicas más frecuentes en pacientes de 65 años o más de tres centros de salud con distintas características demográficas, sociales y administrativas, y las posibles diferencias entre ellos, por medio del análisis descriptivo de sus fichas clínicas entre abril de 2010 y abril de 2011. Los resultados mostraron una mayor prevalencia de patologías dermatológicas en el centro de salud primario, presentándose con mayor frecuencia en pacientes de sexo femenino. Sin importar el centro de salud de origen, las enfermedades infecciosas de la piel son el grupo de mayor prevalencia. Estos resultados coinciden con otros estudios a nivel latinoamericano, pero difieren de estudios realizados en países desarrollados.

The aging population is a worldwide phenomenon which implies all functions including skin, with pathological prevalence of xerosis, itching, infection, and neoplasia. This study establish the dermatological pathologies most frequently seen in patients 65 years and older in three health centers with distinct demographic, social, and administrative characteristics - and the possible differences between them – through the descriptive analysis of their medical records from April 2010 to April 2011. The results showed a greater prevalence of dermatological pathologies in the first health center, with greater frequency in female patients. No matter the health center, infectious diseases of the skin are the prevalent group. The results concur with other Latin American studies, but differ from studies in developed countries.

Análisis de variables epidemiológicas, clínicas e histopatológicas del cáncer de piel en el Hospital Regional de Arica, Chile (2007-2011) / Analysis of epidemiological, clinical and histopathological variables of skin cancer in the Regional Hospital of Arica, Chile (2007-2011)

Introducción: el cáncer cutáneo es un problema de salud pública. Múltiples factores influyen en el desarrollo de esta neoplasia. El nortede Chile y particularmente Arica, tienen condiciones diferentes al restodel país, presentan mayores niveles de radiación solar, elevada foto exposición y un importante número de población amerindia. Objetivo: Determinar las tasas de incidencia de Carcinoma Basocelular (CBC),Carcinoma Espinocelular CEC y Melanoma Maligno (MM) en la población beneficiaria del Hospital Regional de Arica entre 2007 y 2011 ycaracterizar los tumores utilizando variables clínicas e histopatológicas. Metodología: Se analizaron 22.787 informes histopatológicos de biopsiasen el Hospital Regional de Arica, durante los años 2007 - 2011.Se obtuvieron 288 informes compatibles con cáncer de piel. Se analizaronlas variables de sexo, edad, raza, localización anatómica y tipo histológico. El análisis estadístico se realizó mediante test de Fisher considerando un valor de p menor a 0,05 significativo. Resultados: Se obtuvieron 183 pacientes (64%) con CBC, 93 (32%) con CEC y 12 (4%)de MM. Las tasas de incidencia en total presentaron fluctuaciones,con un patrón decreciente, en CBC (44,03/ 100.000 en 2007, a 13.68/100.000 en 2011) y CEC (16,08/100.000 en 2007 a 8,92/ 100.000 en2011). La localización más frecuente fue cabeza y cuello, 154 pacientespara CBC (84%) y 44 con CEC (47%). En cuanto MM la ubicación más frecuente fue tronco en varones y extremidades superiores e inferiores,en mujeres...

Introduction: skin cancer is a public health problem. Multiplefactors contribute to its appearance. Northern Chile, particularly Arica, has different conditions to the rest of the countryand showed higher levels of solar radiation, a higher sunexposure and a significant number of Amerindian population. Objetive: Determine the incidence rates of Basal Cell Carcinoma( BCC), Squamous cell carcinoma (SCC) and Malignantmelanoma (MM ) in the target population of Arica RegionalHospital, between 2007 and 2011 and characterize the skintumors according to the clinical and histopathological variables. Methodology: 22,787 histopathological reports from the Regional Hospital of Arica, during 2007-2011 were analyzed.288 reports compatible with skin cancer (BCC, SCC and MM)were obtained. For each tumor the variables of sex, age, race,anatomical location and histological type were analyzed. The statistical analysis was performed by the test of Fisher. Results:183 patients, 64% BCC, 32 % SCC and 4% MM wereobtained. Incidence rates of all skin cancer showed fluctuations with decreasing pattern in BCC (ranging from 44.03 /100,000 in 2007, to 13.68 / 100,000 in 2011) and SCC (rangingfrom 16.08 / 100,000 the year 2007 to 8.92 / 100,000 in2011). The most frequent location was head and neck, 154for BCC (84%) and 44 with SCC (47%). The most frequent location of MM was trunk in males and upper and lower limbsin females...

Carcinoma basocelular en población consultante de cuatro hospitales públicos de la Región Metropolitana: comparación de dos períodos(1995-1999) y (2005-2009) / Basal cell carcinoma in four public hospitals consultant in the Metropolitan Region: comparison of two periods (1995-1999) and (2005-2009)

INTRODUCCIÓN: El Carcinoma basocelular (CBC) es la neoplasia más frecuente en la población humana. Se ha observado un aumento de su incidencia en todos los países, incluyendo a Chile. CBC es un tumor heterogéneo clínica e histológicamente. Entre sus factores de riesgo, destaca la exposición a la radiación ultravioleta. En Chile, en la última década se han realizado numerosas campañas de prevención del cáncer cutáneo y de detección precoz de esta neoplasia. El propósito de este trabajo es comparar el comportamiento del CBC en relación a parámetros demográficos, clínicos e histológicos en dos periodos de tiempo, 1995-1999 y 2005-2009 en la población de cuatro hospitales públicos de Santiago de Chile...

INTRODUCTION: Basal cell carcinoma (BCC) is the most common malignancy in the human population. There has been an increased incidence in all countries, including Chile. BCC is a clinically and histologically heterogeneous tumor. The main risk factor of BCC is the ultraviolet radiation exposure. In Chile, in the last decade, there have been numerous campaigns of skin cancer prevention and early detection of this neoplasm. The purpose of this paper is to compare the behavior of BCC in relation to demographic, clinical and histological parameters in two periods, 1995-1999 and 2005-2009 in the population of four hospitals in Santiago de Chile…

[Body distribution and density of acquired melanocytic nevi in adolescents of low socioeconomic status of Santiago, Chile]. / Análisis de la densidad y distribución anatómica de nevos melanocíticos adquiridos, en adolescentes del estrato socioeconómico bajo de Santiago de Chile.

BACKGROUND: There is an increase in the incidence of malignant melanoma in Chile. Previous studies have shown that the density and size of acquired melanocytic nevi (AMN) are a risk factor for developing malignant melanoma. AIM: To assess the number and anatomical distribution of acquired melanocytic nevi in Chilean adolescents. MATERIAL AND METHODS: The number of AMN was counted in 30 anatomical sites in 201 Chilean school children (111 females), aged from 11 to 15 years. The number of small AMN (2-4.9 mm) and large AMN (>5 mm of diameter) was determined. RESULTS: Mean AMN number per person was 32.7 (95% confidence interval (CI) 30.7-42.3) in males and 29 (95% CI 271-38.6) in females (p =NS). Males had a higher number of AMN in the face, neck and trunk. Females had a higher number of AMN in the upper and lower limbs. Older children, adolescents with history of sunburns and with lighter skin had a higher number of total, small and large nevi. CONCLUSIONS: The average number of AMN found in this study is similar to that reported in the literature. The differences in site distribution between males and females may be explained by a different sun exposure pattern.

Melanoma acral: a propósito de un caso / Acral melanoma: report of a case

Acral melanoma is an uncommon cutaneous malignant tumour, which may arise on the foot. A 73 years old female patient presented with an ulcerated lesion on the sole of the left foot for one year, associated to an older pigmented lesion. The biopsy of both lesions, showed “in situ cutaneous melanoma” in the pigmented lesion and “infiltrating cutaneous melanoma” in the ulcerated lesion. In this case report is discussed the epidemiology of acral melanoma around the world, showing the importance in early recognition and proper management...

Estudio epidemiológico de cáncer de piel del Hospital Regional de Iquique, Región de Tarapacá de Chile (2006 – 2010) / Epidemiological study of skin cancer in the Hospital of Iquique (2006-2010)

Introducción: El cáncer de piel es actualmente una patología de alta prevalencia y ha llegado a constituir un real problema de salud pública. El objetivo de este trabajo fue analizar las tasas de incidencia y características clínicas e histopatológicas del Carcinoma Basocelular (CBC), Espinocelular (CEC) y Melanoma Maligno (MM) en el hospital Regional de Iquique en el período 2006-2010. Metodología: Se analizaron 25.338 informes histopatológicos correspondientes a biopsias realizadas en el Servicio de Anatomía Patológica del Hospital Regional de Iquique, durante los años 2006-2010. Se obtuvieron 257 informes compatibles con cáncer de piel. Para cada tipo de tumor se analizaron las variables de sexo, edad, raza, localización anatómica, servicio de derivación y tipo histológico. El análisis estadístico se realizó a través de STATA®. Resultados: Se obtuvo un 65 por ciento de CBC, 28 por ciento de CEC y un 7 por ciento de MM. Las tasas de incidencia del total de cáncer cutáneo fueron fluctuantes, CBC (entre 11.07 y 22.10/ 100.000 habitantes), CEC (entre 5.03 y 9.33)/ 100.000 habitantes), MM ( 5-9/100.000). En relación con la edad, la edad promedio de CBC fue de 69.8+/- 14.9, CEC fue de 76.9+/-10.3 y MM fue de 64.7+/-15 años. En cuanto a la localización anatómica se encontró CBC, 75 por ciento en cabeza; 14 por ciento en tronco, 3 por ciento en extremidades. En el caso del CEC, 32 por ciento en cabeza, 30 por ciento en tronco, 34 por ciento en extremidades. MM se localizaba en un 38,8 por ciento en extremidades, 33,3 por ciento en cabeza y 11 por ciento en tronco. Discusión: En nuestro estudio se observaron similitudes en la clínica y en las características histopatológicas del cáncer de piel con otras regiones de Chile (Santiago, Concepción); sin embargo, se observó un mayor porcentaje de CEC y la localización anatómica del CEC de esta población difiere de análisis tanto de estudios nacionales como internacionales, encontrando...

Introduction: Skin cancer incidence rates have increased in the last decades. The purpose of this investigation was to study the incidence rates and the clinical and histopathological pattern of Basal Cell Carcinoma (BCC), Squamous cell Carcinoma (SCC) and Malignant Melanoma (MM) in the National Health Service Hospital of Iquique, Chile. Methodology: 25.338 histopathological reports from the Anatomical Pathology Department were analyzed during the period 2006-2010. 257 skin tumors were found. The variables: sex, age, race, anatomical localization and histopathological types of each tumour were also studied. The statistical analysis was performed by STATA®. Results: 65 percent of BCC, 28 percent SCC, 7 percent of MM were found. The skin cancer incidence rates obtained in our study changed from year to year. BCC (changed between 11.07 and 22.1 / 100.000 inhabitants), SCC ( changed between 5.03 and 9.33/ inhabitants), MM ( changed between 5 and 9 /100.000 inhabitants). Regarding the age, the average age of BCC was 69.8+/- 14.9, of SCC was 76.9+/-10.3 and of MM was 64.7+/-15 years old. Concerning the anatomical location of the tumours, 75 percent of BCC were located in the head; 14 percent in trunk, 3% in lower and upper extremities. In the case of SCC, 32 percent were located in the head, 30 percent in the trunk, and 34 percent in lower and upper extremities. Furthermore, a 38.8 percent of MM percent were located in the lower and upper extremities, 33.3 percent of MM in the head and 11 percent in the trunk. Discussion: In this study, the clinical and histopathological pattern of the cutaneous tumours were similar to those found in other cities of Chile (Santiago, Concepción); however; we found a different anatomical location of SCC in this study, different of national and international results. We observed a higher location of SCC in trunk and extremities. Also, it is important to establish that in this study, we observed a higher percentage of SCC...

Carcinoma basocelular de la cara y cuero cabelludo: análisis de la localización, género y tipo histológico en población consultante de hospitales públicos en Región Metropolitana, Chile / Anatomical location of facial and scalp basal cell carcinoma

Introducción: El carcinoma basocelular (CBC) corresponde a la neoplasia maligna más común en la población humana. Sus tasas de incidencia están aumentando en todo el mundo. Objetivo: El propósito de esta investigación fue analizar la localización anatómica del CBC facial y cuero cabelludo, por sexo y agresividad histológica. Metodología: Se analizaron 1732 casos de CBC (958 mujeres, 774 hombres), provenientes de 4 hospitales públicos de Santiago, Chile, durante los años 2005-2009. Las localizaciones analizadas fueron: cuero cabelludo, la frente, los párpados, la zona del ojo, las orejas, la mejilla izquierda, mejilla derecha, región medio facial y el mentón. Los subtipos histológicos Micronodular, Morfeiforme y Metatípico fueron clasificados como histológicamente agresivos, mientras que los tipos histológicos Sólido, Queratótico, Quístico, Adenoideo y Superficial se clasificaron como histológicamente no agresivos. El análisis estadístico se realizó mediante la prueba de Chi cuadrado. Resultados: Se observó una mayor frecuencia de CBC en la región medio facial (42,8 por ciento) seguida de la frente (11,3 por ciento), el párpado (10 por ciento), las orejas (7,5 por ciento), el cuero cabelludo (4,21 por ciento) y el mentón (1,85 por ciento). Discusión: Estos resultados están de acuerdo en su gran mayoría con los obtenidos en publicaciones internacionales. La distribución del CBC en cara está relacionada directamente con el grado de exposición a la radiación ultravioleta de cada sitio anatómico. En cuanto al género, la frecuencia de CBC fue mayor en mujeres que en hombres en todos los lugares anatómicos en el rostro. En el cuero cabelludo, los hombres mostraron una mayor proporción de CBC. En cuanto a la agresividad de los tumores, no hubo diferencias significativas en los lugares observados. Además, los histológicamente no agresivos fueron mayores en frecuencia en todas las localizaciones dentro de la cabeza...

Introduction: Basal cell carcinoma (BCC) of the skin is now the most common malignancy in the human population. Its incidence rates are increasing worldwide. Objective: The purpose of this research was to analyze the anatomical location of facial and scalp BCC, per gender and histological aggressiveness. Methodology: A total of 1732 (958 females, 774 males), BCC from 4 state hospitals from Santiago, Chile (2005-2009) was studied. The analyzed subsides were: scalp, forehead, eyelid, eye zone, ears, left cheek, right cheek, middle face and chin. Micronodular, Morpheiform and Metatipical histological subtypes were classified as aggressive and Superficial, Keratotic, Adenoid, Nodular were classified as non-aggressive histological subtypes. The statistical analysis was performed by the Chi square test. Results: We observed a highest frequency of BCC in middle face (42.8 percent) followed by forehead (11.3 percent), eyelid (10 percent), ears (7.5 percent), scalp (4.21 percent) and chin (1.85 percent). Discussion: These results are mainly in agreement with those obtained in other populations reported in the international literature; the BCC distribution in the head is related to ultraviolet radiation exposure of each anatomical site. Regarding the gender, the frequency of BCC was higher in females than in males in all anatomical locations within the face. In the scalp, males showed a higher proportion of BCC. Regarding the aggressitivity of the tumours, no differences within the locations were observed. Also, non-aggressive histological tumors were higher in frequency in all locations within the head. This investigation helps to identify the possible risk zones of BCC within the face and scalp in the Chilean population.

[Frequency of celiac disease among patients with psoriasis]. / Estudio de enfermedad celíaca en pacientes con psoriasis.

BACKGROUND: A possible relationship has been reported between psoriasis and celiac disease, with common pathogenic mechanisms that may need further investigation. AIM: To investigate the presence of clinical and serological markers for celiac disease in a group of Chilean psoriatic patients. MATERIAL AND METHODS: We included 80 psoriatic patients (42 males) aged 16 to 79 years, whose serum was tested for antitransglutaminase antibodies (ATGA) and antiendomysial antibodies (AEMA). Patients with weakly positive AEMA tests were also tested for antigliadin antibodies (AGA). RESULTS: In six patients (7.5%), AEMA and AGA were positive and one patient was positive for ATGA. An upper gastrointestinal endoscopy and duodenal biopsy was offered to these six patients and five accepted the procedure. Only one had a pathological diagnosis of celiac disease. CONCLUSIONS: Only one of 80 patients with psoriasis had celiac disease (1.2%). Other four patients with positive serologic markers had a normal duodenal biopsy. This group of patients may have latent celiac disease and they should be followed up.

Carcinoma espinocelular en hospitales públicos de la Región Metropolitana de Chile: análisis de la localización anatómica, género y edad / Spinocellular carcinoma in public hospitals metropolitan region, Chile: analysis of anatomic localization, genus and age

Cutaneous squamous cell carcinoma (SCC) is the second most common skin cancer; its incidence is increasing in the last decades worldwide. The purpose of this study was to analyze 1320SCC (716 males and 604 females) from five hospitals of Santiago. The tumours were studied by gender, anatomical localization and age of the patient. For this, 600.000 histopathological reports were reviewed (1992-2001). SCC was more frequent in males than females and also more frequent in older people. The average age was 72.1 +/-14.3 years old in females and 69.5+/-13.2 years old in males. The most frequent anatomical locations in females were the face (51.2 percent), lower extremities (13.9 per cent) and genitals (12.1 percent). The most frequent anatomical locations in males were the face (62.4 percent); genitals (9.8 percent) and lower extremities (8.1 percent ). More number of facial SCC was observed in males than in females; however; more SCC in lower extremities was observed in females than in males. In relation to age, CEC was more frequent in males in the 50-59 and 70-79 years old groups, however; CEC was more frequent in females older than 80 years old. The study of 1320 SCC tumours allows us to analyze risk groups in the Chilean population that help to direct future skin cancer prevention campaigns in Chile.

Museo de cera: una forma de enseñanza de la sífilis en Chile a principios del siglo XX / Wax museum: a form of education of the syphilis in Chile at the beginning of century XX

At the beginning of the twentieth century, Dermatology’s teaching was more complex than today, heavily based on fine semiology. During the last centuries, the art of moulage preparation evolved from 2-dimensional images in black and white to 3-dimensional figures with color andrelief, realistic representations of diseased parts of the human body, essential in a morphological and descriptive discipline. The technique of wax figures in Dermatology began in the nineteenth century in France, at St. Louis Hospital. Subsequently, Olavide created a wax museum at San Juan de Dios Hospital in Spain. In Chile, wax moulages of syphilis and other sexually transmitted diseases were used for the teaching of Dermatology by the National Health Service. The moulages were carved by Mrs. Anita Lagarrigue and designed by Professor Dr Luis Prunés (Chair of Dermatology at Saint Vincent de Paul Hospital) in the 1940’s. Until today, we have found 15 wax moulages, partially preserved in wooden and glass boxes in the Dermatology Department at the Clinical Hospital of the University of Chile (former Saint Vincent de Paul Hospital). This wax figures collection represents a significant work of art and reflects a veryimportant part of the history of Chilean Dermatology.