RESUMO
The authors have developed a model of acute and chronic aspergillosis induced by Aspergillus fungi injected intraperitoneally to white mice. Subsequent histological evaluation of the mouse viscera identified 3 phases of tissue immunity reactions: non-specific, characterized by mucosal epithelial proliferation and hypersecretion, lymphoid reaction and development of diffuse alveolitis in the lungs, rapid growth of aspergilla; specific, characterized by pronounced proliferative processes, onset of lymphoid-histiocytic and macrophagal pneumonia, emergence of small thin-wall intraalveolar micetomas, absence of aspergilla growth from homogenates of the internal organs; productive, characterized by formation of granuloma, large aspergillomas in the liver and mesenterium. The course of experimental aspergillosis reflects the process of immunity formation in response to advancing infection.
Assuntos
Aspergilose/imunologia , Animais , Modelos Animais de Doenças , CamundongosRESUMO
Thanatogenesis of pulmonary tuberculosis has been studied on autopsy material gained in tuberculosis hospitals of Moscow from 1972 to 1992. The leading cause of lethal outcomes was progressive fibrous-cavernous tuberculosis (71.6% in 1992). Disseminated tuberculosis mortality rose two-fold (14.2% in 1992). Death rate for infiltrative tuberculosis reaches now 5.56%. Tuberculous patients die of the progressive disease in 54.94%, of respiratory distress and cardiac insufficiency in 32.72%. Progressive tuberculosis proved to combine with nontuberculous diseases in 71.87% of the cases.