Broadband photonic-assisted microwave receiver with high cross-channel interference suppression and image rejection.

A broadband photonic-assisted microwave receiver with high cross-channel interference suppression and image rejection is proposed and experimentally demonstrated. At the input of the microwave receiver, a microwave signal is injected into an optoelectronic oscillator (OEO), which functions as a local oscillator (LO) to generate a low-phase noise LO signal as well as a photonic-assisted mixer to down-convert the input microwave signal to the intermediate frequency (IF). A microwave photonic filter (MPF), realized by the joint operation of a phase modulator (PM) in the OEO and a Fabry-Perot laser diode (FPLD), is used as a narrowband filter to select the IF signal. Thanks to the wide bandwidth of the photonic-assisted mixer and the wide frequency tunable range of the OEO, the microwave receiver can support broadband operation. The high cross-channel interference suppression and image rejection are enabled by the narrowband MPF. The system is evaluated experimentally. A broadband operation from 11.27 to 20.85 GHz is demonstrated. For a multi-channel microwave signal with a channel spacing of 2 GHz, a cross-channel interference suppression ratio of 21.95 dB and an image rejection ratio of 21.51 dB are realized. The spurious-free dynamic range (SFDR) of the receiver is also measured to be 98.25 dB·Hz2/3. The performance of the microwave receiver for multi-channel communications is also experimentally evaluated.

Single-mode narrow-linewidth fiber ring laser with SBS-assisted parity-time symmetry for mode selection.

A single-longitudinal-mode narrow-linewidth fiber ring laser with stimulated Brillouin scattering (SBS) assisted parity-time (PT) symmetry for mode selection in a single fiber loop is proposed and experimentally demonstrated. When an optical pump is launched into the fiber loop along one direction, an SBS gain for the Stokes light along the opposite direction is produced. For two light waves at the Stokes frequency propagating along the two opposite directions, one will have a net gain and the other will have a net loss. By incorporating a fiber Bragg grating (FBG) with partial reflection in the loop, mutual coupling between the two counterpropagating Stokes light waves is achieved. The SBS gain can be controlled by tuning the angle between the polarization directions of the pump and the Stokes light waves through a polarization controller (PC). Once the gain and loss coefficients between the two counterpropagating light waves are controlled to be identical in magnitude, and that the gain coefficient is greater than the coupling coefficient caused by the FBG, PT symmetry breaking is achieved, making the mainmode to sidemode ratio highly enhanced, single mode lasing is thus achieved. The approach is evaluated experimentally. For a fiber ring laser with a cavity length of 8.02 km, single-mode lasing with a narrow 3-dB linewidth of 368 Hz and a sidemode suppression ratio of around 33 dB is demonstrated. The wavelength tunable range from 1550.02 to 1550.18 nm is also demonstrated.

Photonic generation of a microwave waveform with an ultra-long temporal duration using a frequency-shifting dispersive loop.

A photonic approach to generate a linearly chirped microwave waveform (LCMW) with an ultra-long temporal duration is proposed and experimentally demonstrated. The microwave waveform generation is achieved based on spectral-shaping and wavelength-to-time (SS-WTT) mapping by using a Mach-Zehnder interferometer (MZI) and a frequency-shifting dispersive loop (FSDL), respectively. To make the generated microwave waveform have an ultra-long temporal duration, the FSDL is operating to allow a spectrally shaped optical pulse to recirculate in a dispersive loop multiple times with a low propagating loss, to generate a microwave waveform with a temporal duration that is more than one order of magnitude longer than that of a microwave waveform generated using a dispersive element without recirculation. To generate a LCMW, the spectral shaper is configured to have a free spectral range (FSR) that is linearly increasing or decreasing with optical wavelength. The proposed approach is experimentally demonstrated. Two LCMWs, by allowing an optical pulse recirculating in the FSDL for three and seven round trips, tripled and septupled temporal durations of 64 and 182 ns are generated. The generation of two LCMWs with ultra-long temporal durations of 370 ns and 450 ns are also demonstrated.

Optoelectronic oscillator with improved sidemode suppression by joint use of spectral Vernier effect and parity-time symmetry.

An optoelectronic oscillator (OEO) with improved sideband suppression by joint use of the spectral Vernier effect and parity-time (PT) symmetry is proposed and experimentally demonstrated. The spectral Vernier effect is implemented using two mutually coupled loops with different loop lengths, to increase the effective free spectral range (FSR). To further increase the mode selection capability to ensure stable single-frequency oscillation with an increased sidemode suppression ratio (SMSR), PT symmetry is implemented, in which the two mutually coupled loops are controlled with balanced gain and loss. Thanks to the combined effects, stable single-mode oscillation with a significantly increased SMSR is achieved. The proposed OEO is studied theoretically and evaluated experimentally. The results show that for a generated microwave signal at 10 GHz, the SMSR is 67.68 dB, which is increased by 11.20 dB or 26.05 dB, when using only the spectral Vernier effect or only the PT symmetry. Thanks to the long length of the longer loop, good phase noise performance is still maintained. The measurement shows that a phase noise as low as -124.5 dBc/Hz at an offset frequency of 10 kHz is achieved.

Microwave frequency measurement using a silicon integrated microring resonator.

Photonics-assisted instantaneous frequency measurement of a microwave signal using a silicon integrated microring resonator (MRR) is proposed and experimentally demonstrated. The frequency of a microwave signal has a unique relationship with the power ratio between the two microwave signals at the outputs of two microwave photonic filters (MPF) with complementary frequency responses. The key device to implement the MPFs is a silicon integrated MMR, which is employed to convert a phase-modulated optical signal to an intensity-modulated optical signal by placing two optical carriers at the complementary slopes of the MRR. For a given frequency measurement range and resolution, an MRR is designed and fabricated, and its use for instantaneous microwave frequency (IMF) measurement is implemented. For the fabricated MRR, an IMF measurement range of 14-25 GHz with a measurement accuracy of ±0.2GHz is achieved.

Low jitter microwave pulse train generation based on an optoelectronic oscillator.

We demonstrate an approach to ultra-short pulse train generation with a low time jitter based on pulse compression of a frequency comb generated by a dual-loop optoelectronic oscillator (OEO). The proposed dual-loop OEO consists of two feedback loops, with one having a long loop length and the other a short loop length. In the long loop, a phase modulator (PM) cascaded with a Mach-Zehnder modulator (MZM) are employed, and in the short loop, only the MZM is included. Due to the Vernier effect, the use of the dual-loop structure can facilitate mode selection to generate a single-frequency microwave carrier with multiple optical sidebands corresponding to an optical comb. By adjusting the phase relationship between the optical sidebands using a dispersion compensating fiber (DCF), a stable optical pulse train is generated. Thanks to the low phase noise nature of an OEO, the generated pulse train has a low time jitter. The proposed approach is evaluated experimentally. A pulse train with a repetition frequency of 2.023 GHz and a pulse width of 40 ps is generated. The single-sideband (SSB) phase noise of the carrier frequency generated by the OEO is measured to be -118 dBc/Hz at a 10-kHz offset frequency, corresponding to a time jitter of the pulse train of 391.2 fs. The phase noise can be further reduced if an active cavity stabilization mechanism is adopted, enabling further reduction in the time jitter to the order of tens of femtoseconds.

Optical dynamic memory based on an integrated active ring resonator.

All-optical computing has been considered a solution for future computers to overcome the speed bottleneck encountered by the current electronic computers. High-speed optical memory is one of the key building blocks in realizing all-optical computing. In this Letter, we demonstrate an optical dynamic memory based on an amplified high Q-factor ring resonator that has the capability to achieve an infinite memory time. The optical memory uses an external pulse train to refresh the resonator, an operation in analogy to an electronic dynamic random-access memory widely used in modern computers, but at a speed that can be orders of magnitude faster. In our demonstration, a writing speed of 2.5 GHz is achieved with instant reading capability. The maximum writing speed can be as fast as 27.3 GHz if a shorter pulse is used.

Microwave photonic integrator based on a multichannel fiber Bragg grating.

We propose and experimentally demonstrate a microwave photonic integrator based on a multichannel fiber Bragg grating (FBG) working in conjunction with a dispersion compensating fiber (DCF) to provide a step group delay response with no in-channel dispersion-related distortion. The multichannel FBG is designed based on the spectral Talbot effect, which provides a large group delay dispersion (GDD) within each channel. A step group delay response can then be achieved by cascading the multichannel FBG with a DCF having a GDD opposite the in-channel GDD. An optical comb, with each comb line located at the center of each channel of the FBG, is modulated by a microwave signal to be integrated. At the output of the DCF, multiple time-delayed replicas of the optical signal, with equal time delay spacing are obtained and are detected and summed at a photodetector (PD). The entire operation is equivalent to the integration of the input microwave signal. For a multichannel FBG with an in-channel GDD of 730 ps/nm and a DCF with an opposite GDD, an integrator with a bandwidth of 2.9 GHz and an integration time of 7 ns is demonstrated.

High speed and high resolution interrogation of a fiber Bragg grating sensor based on microwave photonic filtering and chirped microwave pulse compression.

High speed and high resolution interrogation of a fiber Bragg grating (FBG) sensor based on microwave photonic filtering and chirped microwave pulse compression is proposed and experimentally demonstrated. In the proposed sensor, a broadband linearly chirped microwave waveform (LCMW) is applied to a single-passband microwave photonic filter (MPF) which is implemented based on phase modulation and phase modulation to intensity modulation conversion using a phase modulator (PM) and a phase-shifted FBG (PS-FBG). Since the center frequency of the MPF is a function of the central wavelength of the PS-FBG, when the PS-FBG experiences a strain or temperature change, the wavelength is shifted, which leads to the change in the center frequency of the MPF. At the output of the MPF, a filtered chirped waveform with the center frequency corresponding to the applied strain or temperature is obtained. By compressing the filtered LCMW in a digital signal processor, the resolution is improved. The proposed interrogation technique is experimentally demonstrated. The experimental results show that interrogation sensitivity and resolution as high as 1.25 ns/µÎµ and 0.8 µÎµ are achieved.

Time-delay to intensity mapping based on a second-order optical integrator: application to optical arbitrary waveform generation.

We propose and validate experimentally a time-delay to intensity mapping process based on second-order optical integrators. This mapping provides dynamic control of the intensity modulation profile of a waveform based on a purely passive and linear process. In particular, we can realize linear intensity control by tuning the time-delay between two optical pulses launched into a second-order optical integrator. We suggest and experimentally prove the use of this mapping process for reconfigurable optical arbitrary waveform generation.

Interrogation of a linearly chirped fiber Bragg grating sensor with high resolution using a linearly chirped optical waveform.

An approach to the interrogation of a linearly chirped fiber Bragg grating (LCFBG) sensor using a linearly frequency-modulated (or chirped) optical waveform (LFMOW) with a high resolution is proposed and experimentally demonstrated. An LFMOW is generated at a laser diode through linear frequency modulation. The generated LFMOW is then launched into an LCFBG pair consisting of two identical LCFBGs, with one serving as a sensing LCFBG and the other as a reference LCFBG. The reflection of the LFMOW from the two LCFBGs would lead to two time delayed LFMOWs. By beating the LFMOWs at a photodetector, a microwave signal with a beat frequency that is proportional to the time delay difference between the two reflected LFMOWs is generated. By measuring the frequency change of the beat signal, the strain applied to the sensing LCFBG is estimated. The proposed approach is experimentally evaluated. An LCFBG sensor with a resolution of 0.25 µÎµ is experimentally demonstrated.

Efficacy analysis of three brain stimulation techniques for Alzheimer's disease: a meta-analysis of repeated transcranial magnetic stimulation, transcranial direct current stimulation, and deep brain stimulation.

INTRODUCTION: This systematic review and meta-analysis study investigates the efficacy of repeated transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS), and deep brain stimulation (DBS) using neuropsychological assessments as a potential treatment option for Alzheimer's disease (AD). METHODS: PubMed, Embase, and the Cochrane Library were searched for studies on rTMS, tDCS, and DBS for the treatment of patients with AD between April 1970 and October 2022. The mini-Mental State Examination (MMSE) and AD Assessment Scale - Cognitive Subscale (ADAS-Cog) were adopted as the efficacy index. RESULTS: The analysis yielded 17 eligible studies. rTMS greatly improved the cognition of patients with AD (immediate post-treatment WMD of MMSE score: 2.06, p < 0.00001; short-term follow-up WMD of MMSE score: 2.12, p = 0.006; WMD of ADAS-Cog score in single-arm studies: -4.97, p = 0.001). DBS did not reverse the progression of cognitive decline (WMD of ADAS-Cog score in single-arm studies: 7.40, p < 0.00001). Furthermore, tDCS demonstrated no significant efficacy in improving cognition in random clinical trials or single-arm studies. CONCLUSION: rTMS is a promising non-medicinal alternative for cognitive improvement inpatients with AD.

Hypotension with neurovascular changes and cognitive dysfunction: An epidemiological, pathobiological, and treatment review.

ABSTRACT: Hypotension is a leading cause of age-related cognitive impairment. The available literature evidences that vascular factors are associated with dementia and that hypotension alters cerebral perfusion flow and can aggravate the neurodegeneration of Alzheimer's disease (AD). Despite the discovery of biomarkers and the recent progress made in neurovascular biology, epidemiology, and brain imaging, some key issues remain largely unresolved: the potential mechanisms underlying the neural deterioration observed in AD, the effect of cerebrovascular alterations on cognitive deficits, and the positive effects of hypotension treatment on cognition. Therefore, further well-designed studies are needed to unravel the potential association between hypotension and cognitive dysfunction and reveal the potential benefits of hypotension treatment for AD patients. Here, we review the current epidemiological, pathobiological, and treatment-related literature on neurovascular changes and hypotension-related cognitive dysfunction and highlight the unsettled but imminent issues that warrant future research endeavors.

Synchronous monitoring of brain-heart electrophysiology using heart rate variability coupled with rapid quantitative electroencephalography in orthostatic hypotension patients with α-synucleinopathies: Rapid prediction of orthostatic hypotension and preliminary exploration of brain stimulation therapy.

BACKGROUND: In α-synucleinopathies, the dysfunction of the autonomic nervous system which typically manifests as orthostatic hypotension (OH) often leads to severe consequences and poses therapeutic challenges. This study aims to discover the brain-cardiac electrophysiological changes in OH patients with α-synucleinopathies using the rapid quantitative electroencephalography (qEEG) coupled with heart rate variability (HRV) technique to identify rapid, noninvasive biomarkers for early warning and diagnosis, as well as shed new light on complementary treatment approaches such as brain stimulation targets. METHODS: In this study, 26 subjects of α-synucleinopathies with OH (α-OH group), 21 subjects of α-synucleinopathies without OH (α-NOH group), and 34 healthy controls (control group) were included from September 2021 to August 2023 (NCT05527067). The heart rate-blood pressure variations in supine and standing positions were monitored, and synchronization parameters of seated resting-state HRV coupled with qEEG were collected. Time-domain and frequency-domain of HRV measures as well as peak frequency and power of the brainwaves were extracted. Differences between these three groups were compared, and correlations between brain-heart parameters were analyzed. RESULTS: The research results showed that the time-domain parameters such as MxDMn, pNN50, RMSSD, and SDSD of seated resting-state HRV exhibited a significant decrease only in the α-OH group compared to the healthy control group (p < 0.05), while there was no significant difference between the α-NOH group and the healthy control group. Several time-domain and frequency-domain parameters of seated resting-state HRV were found to be correlated with the blood pressure changes within the first 5 min of transitioning from supine to standing position (p < 0.05). Differences were observed in the power of beta1 waves (F4 and Fp2) and beta2 waves (Fp2 and F4) in the seated resting-state qEEG between the α-OH and α-NOH groups (p < 0.05). The peak frequency of theta waves in the Cz region also showed a difference (p < 0.05). The power of beta2 waves in the Fp2 and F4 brain regions correlated with frequency-domain parameters of HRV (p < 0.05). Additionally, abnormal electrical activity in the alpha, theta, and beta1 waves was associated with changes in heart rate and blood pressure within the first 5 min of transitioning from supine to standing position (p < 0.05). CONCLUSION: Rapid resting-state HRV with certain time-domain parameters below normal levels may serve as a predictive indicator for the occurrence of orthostatic hypotension (OH) in patients with α-synucleinopathies. Additionally, the deterioration of HRV parameters correlates with synchronous abnormal qEEG patterns, which can provide insights into the brain stimulation target areas for OH in α-synucleinopathy patients.

Brain white matter changes and their associations with non-motor dysfunction in orthostatic hypotension in α-synucleinopathy: A NODDI study.

BACKGROUND: The specific non-motor symptoms associated with α-synucleinopathies, including orthostatic hypotension (OH), cognitive impairment, and emotional abnormalities, have been a subject of ongoing controversy over the mechanisms underlying the development of a vicious cycle among them. The distinct structural alterations in white matter (WM) in patients with α-synucleinopathies experiencing OH, alongside their association with other non-motor symptoms, remain unexplored. This study employs axial diffusivity and density imaging (NODDI) to investigate WM damage specific to α-synucleinopathies with concurrent OH, delivering fresh evidence to supplement our understanding of the pathogenic mechanisms and pathological rationales behind the occurrence of a spectrum of non-motor functional impairments in α-synucleinopathies. METHODS: This study recruited 49 individuals diagnosed with α-synucleinopathies, stratified into an α-OH group (n = 24) and an α-NOH group (without OH, n = 25). Additionally, 17 healthy controls were included for supine and standing blood pressure data collection, as well as neuropsychological assessments. Magnetic resonance imaging (MRI) was utilized for the calculation of NODDI parameters, and tract-based spatial statistics (TBSS) were employed to explore differential clusters. The fibers covered by these clusters were defined as regions of interest (ROI) for the extraction of NODDI parameter values and the analysis of their correlation with neuropsychological scores. RESULTS: The TBSS analysis unveiled specific cerebral regions exhibiting disparities within the α-OH group as compared to both the α-NOH group and the healthy controls. These differences were evident in clusters that indicated a decrease in the acquisition of the neurite density index (NDI), a reduction in the orientation dispersion index (ODI), and an increase in the isotropic volume fraction (FISO) (p < 0.05). The extracted values from these ROIs demonstrated significant correlations with clinically assessed differences in supine and standing blood pressure, overall cognitive scores, and anxiety-depression ratings (p < 0.05). CONCLUSION: Patients with α-synucleinopathies experiencing OH exhibit distinctive patterns of microstructural damage in the WM as revealed by the NODDI model, and there is a correlation with the onset and progression of non-motor functional impairments.

Aberrant microstructural integrity of white matter in mild and severe orthostatic hypotension: A NODDI study.

OBJECTIVE: Scarce evidence is available to elucidate the association between the abnormal microstructure of white matter (WM) and cognitive performance in patients with orthostatic hypotension (OH). This study investigated the microstructural integrity of WM in patients with mild OH (MOH) and severe OH (SOH) and evaluated the association of abnormal WM microstructure with the broad cognitive domains and cognition-related plasma biomarkers. METHODS: Our study included 72 non-OH (NOH), 17 MOH, and 11 SOH participants. Across the groups, the WM integrity was analyzed by neurite orientation dispersion and density imaging (NODDI), and differences in WM microstructure were evaluated by nonparametric tests and post hoc models. The correlations between WM microstructure and broad cognitive domains and cognition-related plasma biomarkers were assessed by Spearman's correlation analysis. RESULTS: The abnormal WM microstructure was localized to the WM fiber bundles in MOH patients but distributed widely in SOH cohorts (p < 0.05). Further analysis showed that the neurite density index of the left cingulate gyrus was negatively associated with amyloid ß-40, glial fibrillary acidic protein, neurofilament light chain, phospho-tau181 (p < 0.05) but positively with global cognitive function (MOCA, MMSE, AER-III), memory, attention, language, language fluency, visuospatial function and amyloid ß-40 / amyloid ß-42 (p < 0.05). Additionally, other abnormal WM microstructures of OH were associated with broad cognitive domains and cognition-related plasma biomarkers to varying degrees. CONCLUSION: The findings evidence that abnormal WM microstructures may present themselves as early as in the MOH phase and that these structural abnormalities are associated with cognitive functions and cognition-related plasma biomarkers.

Intensive blood pressure control for patients aged over 60: A meta-analysis of the SPRINT, STEP, and ACCORD BP randomized controlled trials.

OBJECTIVES: To evaluate the effects of intensive treatment to lower blood pressure (BP) on the risk of cardiovascular disease (CVD) among patients aged over 60 years. STUDY DESIGN: We extracted individual-level data of participants aged over 60 years from the SPRINT study and ACCORD study first, and then conducted a meta-analysis of major adverse cardiovascular events (MACEs) and other adverse events (hypotension and syncope) and renal outcomes across the SPRINT, STEP, ACCORD BP trials, which included 18,806 participants over 60 years of age. Participants were randomized to receive standard BP treatment or intensive BP treatment. MAIN OUTCOME MEASURES: Hazard ratios (HRs) were used to calculate summary statistics. RESULTS: In this meta-analysis, intensive treatment did not decrease either the all-cause mortality rate (HR: 0.98; 95 % confidence interval [CI]: 0.76-1.26; p = 0.87) or the cardiovascular mortality rate (HR: 0.77; 95 % CI: 0.54-1.08; p = 0.13). The incidence of MACEs (HR: 0.83; 95 % CI: 0.74-0.94; p = 0.003) and stroke (HR: 0.70; 95 % CI: 0.56-0.88; p = 0.002) was reduced, however. Intensive treatment had no effect on acute coronary syndrome (HR: 0.87; 95 % CI: 0.69-1.10; p = 0.24) or heart failure (HR: 0.70; 95 % CI: 0.40-1.22; p = 0.21). Intensive treatment increased the risk of hypotension (HR: 1.46; 95 % CI: 1.12-1.91; p = 0.006) and syncope (HR: 1.43; 95 % CI: 1.06-1.93; p = 0.02). Intensive treatment did not increase the risk of impaired kidney function among patients with chronic kidney disease (HR: 0.98; 95 % CI: 0.41-2.34; p = 0.96) or without chronic kidney disease (HR: 1.77; 95 % CI: 0.48-6.56; p = 0.40) at baseline. CONCLUSIONS: Intensive BP goals reduced the incidence of MACEs and increased the risk of other adverse events without significant changes in mortality or renal outcome.

Twist sensor based on axial strain insensitive distributed Bragg reflector fiber laser.

A novel fiber-optic twist sensor based on a dual-polarization distributed Bragg reflector (DBR) fiber grating laser is proposed and experimentally demonstrated. By beating the signal between the two polarizations of the laser which operates at 1543.154 nm, a signal of 30.78 MHz in frequency domain is observed. The twist will change the fiber birefringence, and resulting in the beat frequency variation between the two polarization modes from the fiber laser. The result shows the beat frequency shifts as a Sinc function curve with the twist angle and both the measuring curve period and twist sensitivity depend on the twist length of the laser cavity. A high twist sensitivity of 6.68 MHz/rad has been obtained at the twist length of 17.5 cm. Moreover, the sensor is insensitive to the environmental temperature, as well as strain along the fiber axis with ultralow beat frequency coefficients, making temperature and axial strain compensation unnecessary.

Highly sensitive liquid-level sensor based on dual-wavelength double-ring fiber laser assisted by beat frequency interrogation.

A highly sensitive liquid-level sensor based on dual-wavelength single-longitudinal-mode fiber laser is proposed and demonstrated. The laser is formed by exploiting two parallel arranged phase-shift fiber Bragg gratings (ps-FBGs), acting as ultra-narrow bandwidth filters, into a double-ring resonators. By beating the dual-wavelength lasing output, a stable microwave signal with frequency stability better than 5 MHz is obtained. The generated beat frequency varies with the change of dual-wavelength spacing. Based on this characteristic, with one ps-FBG serving as the sensing element and the other one acting as the reference element, a highly sensitive liquid level sensor is realized by monitoring the beat frequency shift of the laser. The sensor head is directly bonded to a float which can transfer buoyancy into axial strain on the fiber without introducing other elastic elements. The experimental results show that an ultra-high liquid-level sensitivity of 2.12 × 10(7) MHz/m within the measurement range of 1.5 mm is achieved. The sensor presents multiple merits including ultra-high sensitivity, thermal insensitive, good reliability and stability.

Simultaneous wavelength and frequency encoded microstructure based quasi-distributed temperature sensor.

A novel microstructure based temperature sensor system using hybrid wavelength-division-multiplexing /frequency-division-multiplexing (WDM/FDM) is proposed. The sensing unit is a specially designed microstructure sensor both frequency and wavelength encoded, as well as low insertion loss which makes it have the potential to be densely multiplexed along one fiber. Moreover, the microstructure can be simply fabricated by UV light irradiation on commercial single-mode fiber. Assisted with appropriate demodulation algorithm, the temperature distribution along the fiber can be calculated accurately. In theory, more than 1000 sensors can be multiplexed on one fiber. We experimentally demonstrated the feasibility of the scheme through building a sensor system with 9 microstructures multiplexing and with temperature resolution of 0.4°C.