Comparison of topical honey and povidone iodine-based dressings for wound healing: a systematic review and meta-analysis.

OBJECTIVES: In this review and meta-analysis, we analyse the evidence to compare the efficacy of honey and povidone iodine-based dressings on the outcome of wound healing. METHOD: A systematic literature search was performed using PRISMA guidelines in academic databases including MEDLINE, Scopus, Embase and CENTRAL. A meta-analysis was carried out to assess the effect of honey and povidone iodine-based dressings on mean healing duration, mean hospital stay duration and visual analogue scale (VAS) score of pain. RESULTS: From the search, 12 manuscripts with a total of 1236 participants (mean age: 40.7±11.7 years) were included. The honey-based dressings demonstrated a medium-to-large effect in reduction of mean healing duration (Hedge's g: -0.81), length of hospital stay (-3.1) and VAS score (-1.2) as compared with the povidone iodine-based dressings. We present evidence (level 1b) in favour of using honey for improvement of wound recovery as compared with povidone iodine. CONCLUSION: This review and meta-analysis demonstrate beneficial effects of honey-based dressings over povidone iodine-based dressings for wound recovery.

Comparison of early and delayed removal of dressing following primary closure of clean and contaminated surgical wounds: A systematic review and meta-analysis of randomized controlled trials.

The usefulness of dressing a surgical wound beyond the first 24-48 h of surgery is currently a controversial issue. The aim of this meta-analysis was to compare the early and delayed removal of dressing following primary closure in the management of clean and contaminated surgical wounds. Systematic searches were conducted in various databases including Medline, Cochrane Controlled Register of Trials (CENTRAL), Scopus, and Embase from January, 1964 until October, 2019. We used the Cochrane risk of bias tool to assess the quality of published trials. We carried out a meta-analysis with random-effects model and reported pooled risk ratios (RR) with 95% confidence intervals (CIs). In total, we analysed 10 studies with 1,708 participants. All the studies were randomized controlled trials, while the majority of studies had unclear or high bias risks. Early dressing removal was favoured with respect to surgical site infection (pooled RR=0.89; 95% CI: 0.61 to 1.29), patient's perception on safety (pooled RR=0.60; 95% CI: 0.48 to 0.76) and comfort (pooled RR=0.95; 95% CI: 0.74 to 1.22), while the remaining outcomes favoured delayed dressing removal. However, none of the factors had statistically significant difference between two interventions except the patient's perception on safety. To summarize, delayed removal of dressing is not superior to early removal following primary closure of clean or clean-contaminated surgical wounds.

MR imaging of intracranial solitary fibrous tumor: a retrospective study of 7 cases.

OBJECTIVE: To investigate the MR imaging diagnostic features of intracranial solitary fibrous tumors (ISFTs). MATERIALS AND METHODS: Seven patients (mean age of 52.9 years; M:F=3:4) with histopathologically proven ISFTs were identified at our institute. Clinical presentations and pathological features were reviewed. MR Imaging findings including signal intensity, gadopentetate dimeglumine enhanced pattern, and diffusion-weighted imaging (DWI) characterization of the tumors were retrospectively evaluated. RESULTS: Six tumors showed a multi-lobular contour. Five tumors showed heterogeneous signal intensity, and two tumors showed homogeneous signal intensity on T1WI. Low signal intensity linear, curved or interlacing lines were observed within the tumors in all seven cases. Seven tumors demonstrated moderate or strong enhancement, six showed heterogeneous enhancement, and one homogenous enhancement. All tumors showed heterogeneous signal intensity on DWI.A ring-like high signal intensity band distributed around within the tumor was noted in six cases on DWI. CONCLUSION: Diagnostic evidence for ISFT on MR image includes heterogeneous signal intensity, intense enhancement of T2 signal intensity, low signal intensity lines within the tumor, heterogeneous signal intensity on DWI and a ring-like band around the tumor on DWI.