Detalhe da pesquisa
1.
Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2.
Proc Natl Acad Sci U S A
; 121(6): e2317756121, 2024 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38300868
2.
The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases.
J Biol Chem
; 288(13): 9345-62, 2013 Mar 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-23393134
3.
Molecular phylogeny and taxonomy of the genus Vernaya (Mammalia: Rodentia: Muridae) with the description of two new species.
Ecol Evol
; 13(11): e10628, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37953988
4.
RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations.
Cancer Discov
; 13(9): 2012-2031, 2023 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37270847
5.
Combined X-ray, NMR, and kinetic analyses reveal uncommon binding characteristics of the hepatitis C virus NS3-NS4A protease inhibitor BI 201335.
J Biol Chem
; 286(13): 11434-43, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21270126
6.
In vitro resistance profile of the hepatitis C virus NS3 protease inhibitor BI 201335.
Antimicrob Agents Chemother
; 56(1): 569-72, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22024816
7.
Protease and helicase activities of hepatitis C virus genotype 4, 5, and 6 NS3-NS4A proteins.
Biochem Biophys Res Commun
; 391(1): 692-7, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19944069
8.
Use of the fused NS4A peptide-NS3 protease domain to study the importance of the helicase domain for protease inhibitor binding to hepatitis C virus NS3-NS4A.
Biochemistry
; 48(4): 744-53, 2009 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-19119853
9.
The impact of a new genus on the molecular phylogeny of Hemisphaeriini (Hemiptera, Fulgoromorpha, Issidae).
Zookeys
; 880: 61-74, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31649482
10.
Effects of the G376E and G157D mutations on the stability of yeast enolase--a model for human muscle enolase deficiency.
FEBS J
; 275(1): 97-106, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18070103
11.
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.
Science
; 351(6278): 1208-13, 2016 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26912361