Detalhe da pesquisa
1.
Viral clearance, pharmacokinetics and tolerability of ensovibep in patients with mild to moderate COVID-19: A phase 2a, open-label, single-dose escalation study.
Br J Clin Pharmacol
; 89(3): 1105-1114, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36214216
2.
Ensovibep, a SARS-CoV-2 antiviral designed ankyrin repeat protein, is safe and well tolerated in healthy volunteers: Results of a first-in-human, ascending single-dose Phase 1 study.
Br J Clin Pharmacol
; 89(7): 2295-2303, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37057679
3.
The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell-Mediated Killing of AML Leukemic Stem Cells.
Cancer Immunol Res
; 2024 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38683145
4.
Structure-activity relationships of 2-arylamido-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists and their analgesic action.
Bioorg Med Chem Lett
; 22(24): 7314-21, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23147076
5.
The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants.
Nat Biotechnol
; 40(12): 1845-1854, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35864170
6.
First-in-Human Phase I Study of MP0250, a First-in-Class DARPin Drug Candidate Targeting VEGF and HGF, in Patients With Advanced Solid Tumors.
J Clin Oncol
; 39(2): 145-154, 2021 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33301375
7.
Half-life extension using serum albumin-binding DARPin® domains.
Protein Eng Des Sel
; 30(9): 583-591, 2017 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29088432
8.
A Case of Sustained Tumor Regression With MP0274, a Novel DARPin Therapeutic Targeting Human Epidermal Growth Factor Receptor 2 Signaling, in Metastatic Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer After Prior Trastuzumab and Pertuzumab.
JCO Precis Oncol
; 6: e2200006, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36331248
9.
Design and characterization of MP0250, a tri-specific anti-HGF/anti-VEGF DARPin® drug candidate.
MAbs
; 9(8): 1262-1269, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29035637
10.
The TRP family of cation channels: probing and advancing the concepts on receptor-activated calcium entry.
Prog Neurobiol
; 66(4): 243-64, 2002 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-11960680
11.
Structural domains required for channel function of the mouse transient receptor potential protein homologue TRP1beta.
FEBS Lett
; 523(1-3): 193-9, 2002 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-12123831
12.
Inhibition of PDE3, PDE4 and PDE7 potentiates glucocorticoid-induced apoptosis and overcomes glucocorticoid resistance in CEM T leukemic cells.
Biochem Pharmacol
; 79(3): 321-9, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19737543
13.
Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D.
J Immunol
; 178(8): 4820-31, 2007 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17404263
14.
PKCtheta and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytes.
Blood
; 107(12): 4841-8, 2006 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16514061
15.
Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose.
J Biol Chem
; 277(26): 23150-6, 2002 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-11960981
16.
Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2.
J Biol Chem
; 279(13): 12427-37, 2004 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-14718545
17.
Expression profile of the transient receptor potential (TRP) family in neutrophil granulocytes: evidence for currents through long TRP channel 2 induced by ADP-ribose and NAD.
Biochem J
; 371(Pt 3): 1045-53, 2003 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12564954