RESUMO
We studied antioxidant protective effect of comenic acid and potassium comenate in doses of 2, 4, and 8 mg/kg under conditions of oxidative stress in the brain of mice exposed to immobilization stress. Administration of potassium comenate and comenic acid in the above doses for 3 days before stress prevented the development of oxidative processes in the brain of stressed animals. The antioxidant effect of potassium comenate more pronounced.
Assuntos
Antioxidantes/farmacologia , Ácidos Carboxílicos/farmacologia , Pironas/farmacologia , Animais , Animais não Endogâmicos , Masculino , Malondialdeído/metabolismo , Camundongos , Estresse Oxidativo , Restrição Física , Estresse Psicológico/metabolismoRESUMO
The influence of a new substance, lithium salt of comenic acid, on the oxidative processes in the brain of animals under the conditions of acute and long combined stress has been investigated. It is established that lithium comenate (1 and 2 mg/kg) exhibits pronounced dose-dependent antioxidative stress-protective effect, which is manifested in suppression of the hyperproduction of free radicals and depression of the content of malonic dialdehyde (a secondary product of lipid peroxidation) in the brain of stressed animals. The maximum antioxidative stress protection effect under the conditions of acute and long combined stress has been observed for lithium salt ofcomenic acid in a dose of 2 mg/kg.
Assuntos
Antioxidantes/farmacologia , Química Encefálica/efeitos dos fármacos , Encéfalo/metabolismo , Ácidos Carboxílicos/farmacologia , Lítio , Estresse Oxidativo/efeitos dos fármacos , Pironas/farmacologia , Animais , Antioxidantes/química , Ácidos Carboxílicos/química , Radicais Livres/metabolismo , Masculino , Camundongos , Oxirredução , Pironas/química , Ratos , Ratos WistarRESUMO
The study carried out by means of biochemical and electron-microscopic techniques has shown that the antibacterial preparation baliz-2 at low and therapeutic concentrations suppresses the dehydrogenase activity of staphylococcal cells and their membrane fraction.
Assuntos
Antibacterianos/farmacologia , Cetoácidos/farmacologia , Oxirredutases/antagonistas & inibidores , Staphylococcus aureus/efeitos dos fármacos , Membrana Celular/efeitos dos fármacos , Membrana Celular/enzimologia , Membrana Celular/ultraestrutura , Concentração de Íons de Hidrogênio , Microscopia Eletrônica , Staphylococcus aureus/enzimologia , Staphylococcus aureus/ultraestrutura , Fatores de TempoRESUMO
The effect of the antibacterial preparation Balysum on the ultrastructure of S. aureus, as well as on the process of the formation of alpha-toxin and the secretion of plasmacoagulase in this organism, has been studied. Balysum at a concentration of 8% (as used in clinical practice) has been found to induce changes in the ultrastructure of S. aureus as early as within the first 10 minutes. The maximum effect of the preparation is manifested in 60 minutes. At an early period of incubation damages occur in the cell-surface structures and, to a certain extent, in the membrane-ribosomal apparatus. The increased time of incubation leads to more profound changes in these structures and even to the death of the cell. In a highly toxic strain of S. aureus Balysum has proved to decrease the formation of alpha-toxin 4 times, while having no effect on the results of the plasma coagulation test.