Detalhe da pesquisa
1.
A novel tubulin inhibitor, 6h, suppresses tumor-associated angiogenesis and shows potent antitumor activity against non-small cell lung cancers.
J Biol Chem
; 298(7): 102063, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35618020
2.
1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42) inhibits cell proliferation and induces apoptosis via inhibiting ALK and its downstream pathways in Karpas299 cells.
Toxicol Appl Pharmacol
; 450: 116156, 2022 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35803438
3.
Novel microtubule inhibitor SQ overcomes multidrug resistance in MCF-7/ADR cells by inhibiting BCRP function and mediating apoptosis.
Toxicol Appl Pharmacol
; 436: 115883, 2022 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35031325
4.
Design, synthesis and biological evaluation of colchicine glycoconjugates as tubulin polymerization inhibitors.
Bioorg Med Chem
; 58: 116671, 2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35193066
5.
2-Methoxy-5((3,4,5-trimethosyphenyl) seleninyl) phenol causes G2/M cell cycle arrest and apoptosis in NSCLC cells through mitochondrial apoptotic pathway and MDM2 inhibition.
J Biochem Mol Toxicol
; 36(7): e23066, 2022 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-35384151
6.
Harmine-inspired design and synthesis of benzo[d]imidazo[2,1-b]thiazole derivatives bearing 1,3,4-oxadiazole moiety as potential tumor suppressors.
Bioorg Med Chem
; 46: 116367, 2021 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34425477
7.
W436, a novel SMART derivative, exhibits anti-hepatocarcinoma activity by inducing apoptosis and G2/M cell cycle arrest in vitro and in vivo and induces protective autophagy.
J Biochem Mol Toxicol
; 35(8): e22831, 2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-34155709
8.
The novel ALK inhibitor ZX-29 induces apoptosis through inhibiting ALK and inducing ROS-mediated endoplasmic reticulum stress in Karpas299 cells.
J Biochem Mol Toxicol
; 35(3): e22666, 2021 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-33140567
9.
Design, synthesis and anticancer activity of 5-aryl-4-(4-arylpiperazine-1-carbonyl)-1,2,3-thiadiazoles as microtubule-destabilizing agents.
Bioorg Chem
; 106: 104199, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33317837
10.
Design, synthesis and biological evaluation of 1-Aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as novel microtubule destabilizers.
J Enzyme Inhib Med Chem
; 36(1): 549-560, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33522315
11.
3-(3-Methoxyphenyl)-6-(3-amino-4-methoxyphenyl)-7H-[1,2,4] triazolo [3,4-b][1,3,4] thiadiazine, a novel tubulin inhibitor, evokes G2/M cell cycle arrest and apoptosis in SGC-7901 and HeLa cells.
J Cell Biochem
; 121(3): 2184-2196, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31642107
12.
PI3K/AKT/mTOR pathway-related long non-coding RNAs: roles and mechanisms in hepatocellular carcinoma.
Pharmacol Res
; 160: 105195, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32916254
13.
Design, synthesis and evaluation of antiproliferative and antitubulin activities of 5-methyl-4-aryl-3-(4-arylpiperazine-1-carbonyl)-4H-1,2,4-triazoles.
Bioorg Chem
; 104: 103909, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33142419
14.
A novel ALK inhibitor ZYY inhibits Karpas299 cell growth in vitro and in a mouse xenograft model and induces protective autophagy.
Toxicol Appl Pharmacol
; 383: 114781, 2019 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31618659
15.
An exploration of solvent-front region high affinity moiety leading to novel potent ALK & ROS1 dual inhibitors with mutant-combating effects.
Bioorg Med Chem
; 27(20): 115051, 2019 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31492532
16.
Discovery and optimization of tetrahydropyrido[4,3-d]pyrimidine derivatives as novel ATX and EGFR dual inhibitors.
Bioorg Med Chem
; 26(8): 1784-1796, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29496411
17.
A role for the locus coeruleus in the analgesic efficacy of N-acetylaspartylglutamate peptidase (GCPII) inhibitors ZJ43 and 2-PMPA.
Mol Pain
; 13: 1744806917697008, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28326936
18.
Synthesis, biological evaluation and molecular modeling of imidazo[1,2-a]pyridine derivatives as potent antitubulin agents.
Bioorg Med Chem
; 25(15): 4088-4099, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28622907
19.
Microwave-assisted synthesis and biological evaluation of 3,4-diaryl maleic anhydride/N-substituted maleimide derivatives as combretastatin A-4 analogues.
Bioorg Med Chem Lett
; 25(3): 631-4, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25529737
20.
COH-203, a novel microtubule inhibitor, exhibits potent anti-tumor activity via p53-dependent senescence in hepatocellular carcinoma.
Biochem Biophys Res Commun
; 455(3-4): 262-8, 2014 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25449279