Vaccine adherence and adverse events of the SARS-COV vaccine in patients with inflammatory bowel disease.

OBJECTIVE: To assess adherence to and the adverse effects of the SARS-COV vaccine in patients with inflammatory bowel disease (IBD). PATIENTS AND METHODS: This is an observational, analytical, cross-sectional study. Sociodemographic and clinical data, SARS-COV vaccine data, medications for IBD with use during the vaccination period, and adverse events during the vaccination period were collected. Carried out logistic regressions with robust variance estimation to estimate the odds ratio with the respective 95% confidence intervals (95%CI) to assess the factors associated with non-serious adverse effects following vaccine doses as outcome variables. RESULTS: 194 patients participated, with vaccine compliance of 78.3% for three doses of any vaccine (n=152). Local symptoms and mild systemic symptoms predominated, regardless of the type of vaccine. The first dose of the SARS-COV vaccine with AstraZeneca had a higher percentage of patients with vaccine symptoms. AstraZeneca vaccine increased the chance of non-serious adverse effects in IBD patients by 2.65 times (95% CI: 1.38-5.08; p=0.003), regardless of age, gender, physical activity, excess weight, use of disease-modifying drugs, immunobiological and corticosteroids. CoronaVac vaccine was associated with asymptomatic patients at the first dose and reduced the chance of adverse effects by 0.28 times (OR: 0.284; 95%CI: 0.13-0.62; p=0.002). CONCLUSION: Local symptoms and mild systemic symptoms predominated, regardless of the type of vaccine. Using CoronaVac in the first dose reduced the chances of adverse effects, while AstraZeneca increased the risk of adverse effects.

Use of neck circumference as a predictor of cardiovascular risk in chronic kidney patients undergoing haemodialysis who are candidates for transplantation.

INTRODUCTION: Patients undergoing haemodialysis are at great cardiovascular risk. Neck circumference (NC) is a simple and low-cost measure for estimating this risk precociously. The present study aimed to evaluate whether the cardiovascular risk obtained by NC is associated with the main cardiometabolic risk factors in patients on haemodialysis treatment who are on a waiting list for transplantation. METHODS: A cross-sectional study was conducted including 96 patients in a single transplantation centre. Socio-demographic, clinical-laboratory and anthropometric data were collected. NC was considered as a dependent variable and the independent variables were body mass index (BMI), fasting glycaemia and lipid profile, triglyceride and high-density lipoprotein-cholesterol (TGL/HDL-C) ratio, and triglyceride and glycaemia (TyG) index. For the comparison of averages, we used Mann-Whitney and Student's t tests, as well as one-way analysis of variance and Kruskal-Wallis tests. Bivariate and multivariate logistic regression was performed for the association between NC and cardiometabolic risk factors. p < 0.05 was considered statistically significant. RESULTS: There were higher BMI averages, blood glucose, triglycerides (TGL), TGL/HDL-C ratio and TyG index in the tertile 3 of the NC, whereas the HDL-C decreased as the tertile increased. There was a statistically significant risk of cardiovascular disease that was asscoiated, according to NC, with being overweight, high levels of TGL, TGL/HDL-C, TyG index and low HDL-C. CONCLUSIONS: NC is shown to be associated with cardiometabolic risk factors in kidney patients undergoing haemodialysis who are on a transplant waiting list.