Detalhe da pesquisa
1.
Characterization of the Pharmacokinetic and Pharmacodynamic Profile of Apraglutide, a Glucagon-Like Peptide-2 Analog, in Healthy Volunteers.
J Pharmacol Exp Ther
; 386(2): 129-137, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37316329
2.
A multimodal, comprehensive characterization of a cutaneous wound model in healthy volunteers.
Exp Dermatol
; 32(7): 1028-1041, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37051698
3.
A Biomarker Study in Patients with GBA1-Parkinson's Disease and Healthy Controls.
Mov Disord
; 38(5): 783-795, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36916660
4.
Treatment with the Topical Antimicrobial Peptide Omiganan in Mild-to-Moderate Facial Seborrheic Dermatitis versus Ketoconazole and Placebo: Results of a Randomized Controlled Proof-of-Concept Trial.
Int J Mol Sci
; 24(18)2023 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37762625
5.
Clinical validation of digital biomarkers for paediatric patients with asthma and cystic fibrosis: potential for clinical trials and clinical care.
Eur Respir J
; 59(6)2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34887326
6.
Pharmacological profile of ALKS 7119, an investigational compound evaluated for the treatment of neuropsychiatric disorders, in healthy volunteers.
Br J Clin Pharmacol
; 88(6): 2909-2925, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35014069
7.
Intradermal lipopolysaccharide challenge as an acute in vivo inflammatory model in healthy volunteers.
Br J Clin Pharmacol
; 88(2): 680-690, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34293819
8.
Topical antimicrobial peptide omiganan recovers cutaneous dysbiosis but does not improve clinical symptoms in patients with mild to moderate atopic dermatitis in a phase 2 randomized controlled trial.
J Am Acad Dermatol
; 86(4): 854-862, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33010325
9.
Proof of pharmacology of Org 48775-0, a p38 MAP kinase inhibitor, in healthy volunteers.
Br J Clin Pharmacol
; 87(5): 2321-2332, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33201520
10.
A randomized single and multiple ascending dose study in healthy volunteers of LTI-291, a centrally penetrant glucocerebrosidase activator.
Br J Clin Pharmacol
; 87(9): 3561-3573, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33576113
11.
A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective NaV1.8 Inhibitor, in Healthy Male Adults.
Pain Med
; 22(8): 1814-1826, 2021 08 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33543763
12.
Guselkumab induction therapy demonstrates long-lasting efficacy in patients with mild psoriasis, results from a randomized, placebo-controlled exploratory clinical trial.
J Am Acad Dermatol
; 90(2): 395-397, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37804933
13.
Immunomonitoring of Tacrolimus in Healthy Volunteers: The First Step from PK- to PD-Based Therapeutic Drug Monitoring?
Int J Mol Sci
; 20(19)2019 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31547590
14.
No effect of topical digoxin and furosemide for patients with actinic keratosis.
J Eur Acad Dermatol Venereol
; 37(2): e172-e174, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36177541
15.
The use of a battery of pain models to detect analgesic properties of compounds: a two-part four-way crossover study.
Br J Clin Pharmacol
; 83(5): 976-990, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27862179
16.
AZD6280, a novel partial γ-aminobutyric acid A receptor modulator, demonstrates a pharmacodynamically selective effect profile in healthy male volunteers.
J Clin Psychopharmacol
; 35(1): 22-33, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25493397
17.
Evaluation of lecithinized human recombinant super oxide dismutase as cardioprotectant in anthracycline-treated breast cancer patients.
Br J Clin Pharmacol
; 78(5): 950-60, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24844787
18.
Abdominal visceral and subcutaneous fat increase, insulin resistance and hyperlipidemia in testicular cancer patients treated with cisplatin-based chemotherapy.
Acta Oncol
; 53(3): 351-60, 2014 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-23957624
19.
The ClC-1 chloride channel inhibitor NMD670 improves skeletal muscle function in rat models and patients with myasthenia gravis.
Sci Transl Med
; 16(739): eadk9109, 2024 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38507469
20.
Peripheral selectivity of the novel cannabinoid receptor antagonist TM38837 in healthy subjects.
Br J Clin Pharmacol
; 76(6): 846-57, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23601084