Detalhe da pesquisa
1.
Crystal structure of the M5 muscarinic acetylcholine receptor.
Proc Natl Acad Sci U S A
; 116(51): 26001-26007, 2019 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31772027
2.
Assessment of the Molecular Mechanisms of Action of Novel 4-Phenylpyridine-2-One and 6-Phenylpyrimidin-4-One Allosteric Modulators at the M1 Muscarinic Acetylcholine Receptors.
Mol Pharmacol
; 94(1): 770-783, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29691279
3.
Purinergic Receptor Transactivation by the ß2-Adrenergic Receptor Increases Intracellular Ca2+ in Nonexcitable Cells.
Mol Pharmacol
; 91(5): 533-544, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28280061
4.
Endogenous allosteric modulators of G protein-coupled receptors.
J Pharmacol Exp Ther
; 353(2): 246-60, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25650376
5.
Quantification of ligand bias for clinically relevant ß2-adrenergic receptor ligands: implications for drug taxonomy.
Mol Pharmacol
; 85(3): 492-509, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24366668
6.
Single nucleotide variations encoding missense mutations in G protein-coupled receptors may contribute to autism.
Br J Pharmacol
; 2023 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36787962
7.
Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M4 mAChR.
Eur J Med Chem
; 258: 115588, 2023 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37423123
8.
Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics.
Elife
; 122023 05 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37248726
9.
Opportunities and challenges for the development of M1 muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits.
Br J Pharmacol
; 2022 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36355830
10.
Biased Profile of Xanomeline at the Recombinant Human M4 Muscarinic Acetylcholine Receptor.
ACS Chem Neurosci
; 13(8): 1206-1218, 2022 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35380782
11.
Development of Novel 4-Arylpyridin-2-one and 6-Arylpyrimidin-4-one Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor.
ChemMedChem
; 16(1): 216-233, 2021 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32851779
12.
Identification of a Novel Allosteric Site at the M5 Muscarinic Acetylcholine Receptor.
ACS Chem Neurosci
; 12(16): 3112-3123, 2021 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34351123
13.
H2 relaxin is a biased ligand relative to H3 relaxin at the relaxin family peptide receptor 3 (RXFP3).
Mol Pharmacol
; 77(5): 759-72, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20159943
14.
Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias.
Front Pharmacol
; 11: 606656, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33584282
15.
Restoring Agonist Function at a Chemogenetically Modified M1 Muscarinic Acetylcholine Receptor.
ACS Chem Neurosci
; 11(24): 4270-4279, 2020 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33196174
16.
Relaxin family peptide receptor (RXFP1) coupling to G(alpha)i3 involves the C-terminal Arg752 and localization within membrane Raft Microdomains.
Mol Pharmacol
; 75(2): 415-28, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19029286
17.
6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity.
ACS Chem Neurosci
; 10(3): 1099-1114, 2019 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30547573
18.
Relaxin family peptide receptors--from orphans to therapeutic targets.
Drug Discov Today
; 13(15-16): 640-51, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18675759
19.
Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor with Weak Agonist Activity and Diverse Modulatory Profiles.
J Med Chem
; 61(7): 2875-2894, 2018 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29544056
20.
Responses of GPCR135 to human gene 3 (H3) relaxin in CHO-K1 cells determined by microphysiometry.
Ann N Y Acad Sci
; 1041: 332-7, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15956730