RESUMO
INTRODUCTION: The neural correlates of the cognitive dysfunction in first-episode psychosis (FEP) are still unclear. The present review and meta-analysis provide an update of the location of the abnormalities in the fMRI-measured brain response to cognitive processes in individuals with FEP. METHODS: Systematic review and voxel-based meta-analysis of cross-sectional fMRI studies comparing neural responses to cognitive tasks between individuals with FEP and healthy controls (HC) according to PRISMA guidelines. RESULTS: Twenty-six studies were included, comprising 598 individuals with FEP and 567 HC. Individual studies reported statistically significant hypoactivation in the dorsolateral prefrontal cortex (6 studies), frontal lobe (8 studies), cingulate (6 studies) and insula (5 studies). The meta-analysis showed statistically significant hypoactivation in the left anterior insula, precuneus and bilateral striatum. CONCLUSIONS: While the studies tend to highlight frontal hypoactivation during cognitive tasks in FEP, our meta-analytic results show that the left precuneus and insula primarily display aberrant activation in FEP that may be associated with salience attribution to external stimuli and related to deficits in perception and regulation.
Assuntos
Imageamento por Ressonância Magnética , Transtornos Psicóticos , Cognição , Estudos Transversais , Humanos , Lobo Parietal , Transtornos Psicóticos/diagnóstico por imagem , Transtornos Psicóticos/psicologiaRESUMO
INTRODUCTION: The neural correlates of the cognitive dysfunction in first-episode psychosis (FEP) are still unclear. The present review and meta-analysis provide an update of the location of the abnormalities in the fMRI-measured brain response to cognitive processes in individuals with FEP. METHODS: Systematic review and voxel-based meta-analysis of cross-sectional fMRI studies comparing neural responses to cognitive tasks between individuals with FEP and healthy controls (HC) according to PRISMA guidelines. RESULTS: Twenty-six studies were included, comprising 598 individuals with FEP and 567 HC. Individual studies reported statistically significant hypoactivation in the dorsolateral prefrontal cortex (6 studies), frontal lobe (8 studies), cingulate (6 studies) and insula (5 studies). The meta-analysis showed statistically significant hypoactivation in the left anterior insula, precuneus and bilateral striatum. CONCLUSIONS: While the studies tend to highlight frontal hypoactivation during cognitive tasks in FEP, our meta-analytic results show that the left precuneus and insula primarily display aberrant activation in FEP that may be associated with salience attribution to external stimuli and related to deficits in perception and regulation.
RESUMO
Introduction: The neural correlates of the cognitive dysfunction in first-episode psychosis (FEP) are still unclear. The present review and meta-analysis provide an update of the location of the abnormalities in the fMRI-measured brain response to cognitive processes in individuals with FEP.Methods: Systematic review and voxel-based meta-analysis of cross-sectional fMRI studies comparing neural responses to cognitive tasks between individuals with FEP and healthy controls (HC) according to PRISMA guidelines.Results: Twenty-six studies were included, comprising 598 individuals with FEP and 567 HC. Individual studies reported statistically significant hypoactivation in the dorsolateral prefrontal cortex (6 studies), frontal lobe (8 studies), cingulate (6 studies) and insula (5 studies). The meta-analysis showed statistically significant hypoactivation in the left anterior insula, precuneus and bilateral striatum.Conclusions: While the studies tend to highlight frontal hypoactivation during cognitive tasks in FEP, our meta-analytic results show that the left precuneus and insula primarily display aberrant activation in FEP that may be associated with salience attribution to external stimuli and related to deficits in perception and regulation. (AU)
Introducción:Los correlatos neurales de la disfunción cognitiva en el primer episodio psicótico (PEP) aún no están claros. Esta revisión y este metaanálisis proporcionan una actualización de la localización de las anormalidades en la respuesta cerebral medida por fMRI a los procesos cognitivos en individuos con PEP.Métodos: Revisión sistemática y metaanálisis basado en vóxeles de estudios cros-seccionales de fMRI que comparen respuestas neuronales a tareas cognitivas entre individuos con PEP y controles sanos de acuerdo con las guías PRISMA.Resultados: Se incluyeron 26 estudios, que comprendían 598 individuos con PEP y 567 controles sanos. Los estudios individuales reportaban hipoactivación estadísticamente significativa en la corteza prefrontal dorsolateral (6 estudios), el lóbulo frontal (8 estudios), el cíngulo (6 estudios) y la ínsula (5 estudios). El metaanálisis mostró hipoactivación estadísticamente significativa en la ínsula anterior izquierda, el precúneo y el cuerpo estriado bilateral.Conclusiones: Si bien los estudios tienden a resaltar la hipoactivación frontal durante las tareas cognitivas en PEP, nuestros resultados metaanalíticos muestran que el precúneo izquierdo y la ínsula presentan principalmente una activación aberrante en PEP que puede estar asociada con la atribución de saliencia a estímulos externos y relacionada con déficits en la percepción y la regulación. (AU)
Assuntos
Humanos , Ciências da Saúde , Transtornos Neurocognitivos , Córtex CerebralRESUMO
La reserva neural es un subcomponente de la reserva cognitiva y refiere a las diferencias en los paradigmas cognitivos que subyacen al desempeño de tareas en un cerebro sano. Puede darse por diferencias innatas (inteligencia, edad) o ambientales, como el entrenamiento musical. Éste está relacionado con diferencias cerebrales y cognitivas. El objetivo del presente estudio es realizar una revisión bibliográfica de investigaciones que evaluaron rendimiento cognitivo en músicos como no músicos, y establecer diferencias en la reserva cognitiva y, más específicamente, el subcomponente de reserva neural, entre ambos grupos. Se parte de la suposición de que los músicos poseen un rendimiento superior en tareas cognitivas con respecto a los no músicos y que esto está relacionado con una mayor reserva neural debido al entrenamiento musical. Los resultados son contradictorios. Se encontraron algunas diferencias en dominios cercanos a la práctica musical en adultos jóvenes, y en diversos dominios en adultos mayores. Las diferencias entre grupos, que no diferían en inteligencia, podrían ser atribuibles a una mayor reserva cognitiva. También hay relaciones con el tipo de instrumento, los años y la edad de comienzo de la práctica musical. Se sugiere replicar los hallazgos controlando diversas variables(AU)
Neural reserve is a subcomponent of cognitive reserve and refers to the differences in cognitive paradigms that underlie task performance in a healthy brain. It can occur due to innate (intelligence, age) or environmental differences, such as musical training. This is related to brain and cognitive differences. The aim of the present study is to carry out a bibliographic review of investigations that evaluated cognitive performance in musicians as well as non-musicians, and to establish differences in cognitive reserve and, more specifically, the neural reserve subcomponent, between both groups. It is assumed that musicians have superior cognitive tasks performance compared to non-musicians and that this is related to a greater neural reserve due to musical training. The results are contradictory. Some differences were found in domains close to musical practice in young adults, and in various domains in older adults. The differences between groups, which did not differ in intelligence, could be attributable to a greater cognitive reserve. There are also relationships with the type of instrument, the years and the age of beginning of the musical practice. It is suggested to replicate the findings controlling for various variables(AU)