Locomotor Strategy to Perform 6-Minute Walk Test in People with Multiple Sclerosis: A Prospective Observational Study.

Two-thirds of people with Multiple Sclerosis (PwMS) have walking disabilities. Considering the literature, prolonged tests, such as the 6 min walk test, better reflect their everyday life walking capacities and endurance. However, in most studies, only the distance traveled during the 6MWT was measured. This study aims to analyze spatio-temporal (ST) walking patterns of PwMS and healthy people in the 6MWT. Participants performed a 6MWT with measures of five ST variables during three 1 min intervals (initial: 0'-1', middle: 2'30″-3'30″, end: 5'-6') of the 6MWT, using the GAITRite system. Forty-five PwMS and 24 healthy people were included. We observed in PwMS significant changes between initial and final intervals for all ST parameters, whereas healthy people had a rebound pattern but the changes between intervals were rather negligible. Moreover, ST variables' changes were superior to the standard measurement error only for PwMS between initial and final intervals for all ST parameters. This result suggests that the modification in PwMS' walking pattern is effectively due to their walking ability and not to a measurement, and suggests that PwMS could not manage their walking efficiently compared to healthy people, who could maintain their rhythm throughout the 6MWT. Further studies are needed to detect these patterns changes in the early evolution of the disease, identify clinical determinants involved in PwMS' walking pattern, and investigate whether interventions can positively impact this pattern.

The effect of a mobile application for patients living with gynaecological cancer on their physical and psychosocial adaptation.

BACKGROUND: Education of patients with cancer and patient self-management allow better clinical outcomes using e-health or mobile health applications. AIMS: To develop a mobile application to increase the physical and psychosocial adaptation for patients with gynecological cancer who are receiving chemotherapy and to investigate the effectiveness of the mobile application. METHODS: This study was planned as a parallel, single-blind, pre-post test randomised controlled experimental study in which two groups (intervention-control) will be compared. A total of 52 gynecological cancer patients were planned to be included in the study. FINDINGS: This study is in the protocol stage. Therefore, the results of the study have not yet been reported. CONCLUSIONS: Evidence-based information within JineOnkolojik Destek provides rich data on coping with chemotherapy. In addition, the visual and auditory elements, real patient stories and videos, and the ability to ask questions and receive counselling from the research team can positively affect the physical and psychosocial health of the cancer survivors.

The Possible Mechanism of Physiological Adaptation to the Low-Se Diet and Its Health Risk in the Traditional Endemic Areas of Keshan Diseases.

Selenium is an essential trace element for humans and animals. As with oxygen and sulfur, etc., it belongs to the sixth main group of the periodic table of elements. Therefore, the corresponding amino acids, such as selenocysteine (Sec), serine (Ser), and cysteine (Cys), have similar spatial structure, physical, and chemical properties. In this review, we focus on the neglected but key role of serine in a possible mechanism of the physiological adaptation to Se-deficiency in human beings with an adequate intake of dietary protein: the insertion of Cys in place of Sec during the translation of selenoproteins dependent on the Sec insertion sequence element in the 3'UTR of mRNA at the UGA codon through a novel serine-dependent pathway for the de novo synthesis of the Cys-tRNA[Ser]Sec, similar to Sec-tRNA[Ser]Sec. We also discuss the important roles of serine in the metabolism of selenium directly or indirectly via GSH, and the maintenance of selenium homostasis regulated through the methylation modification of Sec-tRNA[Ser]Sec at the position 34U by SAM. Finally, we propose a hypothesis to explain why Keshan disease has gradually disappeared in China and predict the potential health risk of the human body in the physiological adaptation state of low selenium based on the results of animal experiments.

Training Loads and RSA and Aerobic Performance Changes During the Preseason in Youth Soccer Squads.

The aims of this study were to compare the internal training load (ITL) in soccer players of two competitive age groups (under-15 [U-15] and under-19 [U-19]) during an 8-week preseason training period and compare the associated changes in physical performance measures. Eighteen U-15 and twelve U-19 players were monitored over an 8-week period during the preseason phase. The ITL was monitored using the session rating of perceived exertion (RPE) method. Before and after the preseason period, physical performance was assessed by best (RSAbest) and mean (RSAmean) times in a repeated sprint ability (RSA) test and peak velocity derived from the Carminatti test (PVT-CAR). Total weekly ITL increased with age (U-15: 13770 ± 874 AU vs. U-19: 33584 ± 2506 AU; p < 0.001). In addition, U-19 players perceived training sessions as heavier than U-15 players (6.1 ± 0.3 vs. 5.3 ± 0.3 AU, respectively; p < 0.001). After the preseason period, very likely to almost certainly positive changes were observed for all performance measures in both age groups. However, the U-15 group had possibly superior gains in RSAbest (+1.40%, 90%CL -0.29 to 3.05, with ES = 0.35) and likely higher effects in RSAmean (+1.89%, 90%CL 0.04 to 3.70, with ES = 0.53) and PVT-CAR (+2.71%, 90%CL 0.35 to 5.01, with ES = 0.37) compared to the U-19 group. In conclusion, our findings demonstrate that the U-19 group accumulate higher total weekly ITLs than the U-15 group during the preseason phase due to longer and heavier training sessions. However, the U-15 group obtained superior gains in soccer-specific physical abilities while accumulating half the total ITLs during lighter training sessions.