RESUMO
Clinical outcomes related to congenital Zika syndrome (CZS) include microcephaly accompanied by specific brain injuries. Among several CZS outcomes that have been described, epilepsy and motor impairments are present in most cases. Pharmacological treatment for seizures resulting from epilepsy is performed with anticonvulsant drugs, which in the long term are related to impairments in the child's neuropsychomotor development. Here, we describe the results from a two-year follow-up of a cohort of children diagnosed with CZS related to the growth of the head circumference and some neurological and motor outcomes, including the pharmacological approach, and its results in the treatment of epileptic seizures. This paper is part of a prospective cohort study carried out in the state of Mato Grosso Sul, Brazil, based on a Zika virus (ZIKV)-exposed child population. Our data were focused on the assessment of head circumference growth and some neurological and motor findings, including the description of seizure conditions and pharmacological management in two periods. Among the 11 children evaluated, 8 had severe microcephaly associated with motor impairment and/or epilepsy. Seven children were diagnosed with epilepsy. Of these, 3 had West syndrome. In four children with other forms of epilepsy, there was no pharmacological control.
Assuntos
Anticonvulsivantes/uso terapêutico , Epilepsia/tratamento farmacológico , Microcefalia/virologia , Espasmos Infantis/tratamento farmacológico , Infecção por Zika virus/patologia , Brasil , Pré-Escolar , Epilepsia/virologia , Feminino , Cabeça/anatomia & histologia , Humanos , Lactente , Recém-Nascido , Microcefalia/patologia , Hipertonia Muscular/virologia , Malformações do Sistema Nervoso/virologia , Paresia/virologia , Gravidez , Complicações Infecciosas na Gravidez/virologia , Estudos Prospectivos , Reflexo Anormal/fisiologia , Espasmos Infantis/virologia , Zika virus/patogenicidadeRESUMO
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Assuntos
Humanos , Masculino , Recém-Nascido , Infecções por Coronavirus/diagnóstico , Pneumonia Viral/diagnóstico , Betacoronavirus/genética , Febre/virologia , Hipertonia Muscular/virologia , Pandemias , Reação em Cadeia da PolimeraseRESUMO
Neurodevelopmental follow-up of neonates with vertically transmitted Chikungunya fever has been infrequently reported. We herein report neurodevelopment follow up of two such babies at 3 year of age.
Assuntos
Infecções por Alphavirus/patologia , Doenças do Recém-Nascido/patologia , Doenças do Recém-Nascido/virologia , Infecções por Alphavirus/transmissão , Febre de Chikungunya , Feminino , Humanos , Recém-Nascido , Transmissão Vertical de Doenças Infecciosas , Masculino , Hipertonia Muscular/patologia , Hipertonia Muscular/virologiaRESUMO
Respiratory syncytial virus is a common cause of infection in children. The authors summarize the clinical and diagnostic features of 9 patients admitted to the pediatric intensive care unit with neurological consultation. Patients were aged 5 weeks to 3 years. Four had seizures, 4 had cardiac arrest, and 1 had hypertonia. Results of brain magnetic resonance imaging in 5 patients was abnormal in 1. Cerebrospinal fluid in 4 patients showed elevated protein in 1. Serum sodium was low in 2 patients and normal in 7. Electroencephalograms in 8 patients were abnormal in 7. Increased risk of neurological complications of respiratory syncytial virus should be considered in any patient with documented infection requiring intensive care. Clinical manifestations may include seizures, encephalopathy, and abnormal neurological examination. The authors' data suggest that the electroencephalogram provides a sensitive method for detection of neurological insult in this group of patients.