Pesquisa | Biblioteca Virtual em Saúde

1.

A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma.

Pozniak, Joanna; Pedri, Dennis; Landeloos, Ewout; Van Herck, Yannick; Antoranz, Asier; Vanwynsberghe, Lukas; Nowosad, Ada; Roda, Niccolò; Makhzami, Samira; Bervoets, Greet; Maciel, Lucas Ferreira; Pulido-Vicuña, Carlos Ariel; Pollaris, Lotte; Seurinck, Ruth; Zhao, Fang; Flem-Karlsen, Karine; Damsky, William; Chen, Limin; Karagianni, Despoina; Cinque, Sonia; Kint, Sam; Vandereyken, Katy; Rombaut, Benjamin; Voet, Thierry; Vernaillen, Frank; Annaert, Wim; Lambrechts, Diether; Boecxstaens, Veerle; Saeys, Yvan; van den Oord, Joost; Bosisio, Francesca; Karras, Panagiotis; Shain, A Hunter; Bosenberg, Marcus; Leucci, Eleonora; Paschen, Annette; Rambow, Florian; Bechter, Oliver; Marine, Jean-Christophe.

Cell ; 187(1): 166-183.e25, 2024 01 04.

Artigo em Inglês | MEDLINE | ID: mdl-38181739

2.

Relatlimab and nivolumab in the treatment of melanoma.

Au, Lewis; Larkin, James; Turajlic, Samra.

Cell ; 185(26): 4866-4869, 2022 12 22.

Artigo em Inglês | MEDLINE | ID: mdl-36563660

3.

Topical therapy for regression and melanoma prevention of congenital giant nevi.

Choi, Yeon Sook; Erlich, Tal H; von Franque, Max; Rachmin, Inbal; Flesher, Jessica L; Schiferle, Erik B; Zhang, Yi; Pereira da Silva, Marcello; Jiang, Alva; Dobry, Allison S; Su, Mack; Germana, Sharon; Lacher, Sebastian; Freund, Orly; Feder, Ezra; Cortez, Jose L; Ryu, Suyeon; Babila Propp, Tamar; Samuels, Yedidyah Leo; Zakka, Labib R; Azin, Marjan; Burd, Christin E; Sharpless, Norman E; Liu, X Shirley; Meyer, Clifford; Austen, William Gerald; Bojovic, Branko; Cetrulo, Curtis L; Mihm, Martin C; Hoon, Dave S; Demehri, Shadmehr; Hawryluk, Elena B; Fisher, David E.

Cell ; 185(12): 2071-2085.e12, 2022 06 09.

Artigo em Inglês | MEDLINE | ID: mdl-35561684

4.

LAG-3 as the third checkpoint inhibitor.

Aggarwal, Vaishali; Workman, Creg J; Vignali, Dario A A.

Nat Immunol ; 24(9): 1415-1422, 2023 09.

Artigo em Inglês | MEDLINE | ID: mdl-37488429

5.

A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer.

Ott, Patrick A; Hu-Lieskovan, Siwen; Chmielowski, Bartosz; Govindan, Ramaswamy; Naing, Aung; Bhardwaj, Nina; Margolin, Kim; Awad, Mark M; Hellmann, Matthew D; Lin, Jessica J; Friedlander, Terence; Bushway, Meghan E; Balogh, Kristen N; Sciuto, Tracey E; Kohler, Victoria; Turnbull, Samantha J; Besada, Rana; Curran, Riley R; Trapp, Benjamin; Scherer, Julian; Poran, Asaf; Harjanto, Dewi; Barthelme, Dominik; Ting, Ying Sonia; Dong, Jesse Z; Ware, Yvonne; Huang, Yuting; Huang, Zhengping; Wanamaker, Amy; Cleary, Lisa D; Moles, Melissa A; Manson, Kelledy; Greshock, Joel; Khondker, Zakaria S; Fritsch, Ed; Rooney, Michael S; DeMario, Mark; Gaynor, Richard B; Srinivasan, Lakshmi.

Cell ; 183(2): 347-362.e24, 2020 10 15.

Artigo em Inglês | MEDLINE | ID: mdl-33064988

6.

A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistance.

Huang, Alexander C; Zappasodi, Roberta.

Nat Immunol ; 23(5): 660-670, 2022 05.

Artigo em Inglês | MEDLINE | ID: mdl-35241833

7.

Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade.

Benci, Joseph L; Johnson, Lexus R; Choa, Ruth; Xu, Yuanming; Qiu, Jingya; Zhou, Zilu; Xu, Bihui; Ye, Darwin; Nathanson, Katherine L; June, Carl H; Wherry, E John; Zhang, Nancy R; Ishwaran, Hemant; Hellmann, Matthew D; Wolchok, Jedd D; Kambayashi, Taku; Minn, Andy J.

Cell ; 178(4): 933-948.e14, 2019 08 08.

Artigo em Inglês | MEDLINE | ID: mdl-31398344

8.

Intratumoral follicular regulatory T cells curtail anti-PD-1 treatment efficacy.

Eschweiler, Simon; Clarke, James; Ramírez-Suástegui, Ciro; Panwar, Bharat; Madrigal, Ariel; Chee, Serena J; Karydis, Ioannis; Woo, Edwin; Alzetani, Aiman; Elsheikh, Somaia; Hanley, C J; Thomas, G J; Friedmann, Peter S; Sanchez-Elsner, Tilman; Ay, Ferhat; Ottensmeier, Christian H; Vijayanand, Pandurangan.

Nat Immunol ; 22(8): 1052-1063, 2021 08.

Artigo em Inglês | MEDLINE | ID: mdl-34168370

9.

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade.

Jerby-Arnon, Livnat; Shah, Parin; Cuoco, Michael S; Rodman, Christopher; Su, Mei-Ju; Melms, Johannes C; Leeson, Rachel; Kanodia, Abhay; Mei, Shaolin; Lin, Jia-Ren; Wang, Shu; Rabasha, Bokang; Liu, David; Zhang, Gao; Margolais, Claire; Ashenberg, Orr; Ott, Patrick A; Buchbinder, Elizabeth I; Haq, Rizwan; Hodi, F Stephen; Boland, Genevieve M; Sullivan, Ryan J; Frederick, Dennie T; Miao, Benchun; Moll, Tabea; Flaherty, Keith T; Herlyn, Meenhard; Jenkins, Russell W; Thummalapalli, Rohit; Kowalczyk, Monika S; Cañadas, Israel; Schilling, Bastian; Cartwright, Adam N R; Luoma, Adrienne M; Malu, Shruti; Hwu, Patrick; Bernatchez, Chantale; Forget, Marie-Andrée; Barbie, David A; Shalek, Alex K; Tirosh, Itay; Sorger, Peter K; Wucherpfennig, Kai; Van Allen, Eliezer M; Schadendorf, Dirk; Johnson, Bruce E; Rotem, Asaf; Rozenblatt-Rosen, Orit; Garraway, Levi A; Yoon, Charles H.

Cell ; 175(4): 984-997.e24, 2018 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-30388455

10.

An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential.

Wang, Liqin; Leite de Oliveira, Rodrigo; Huijberts, Sanne; Bosdriesz, Evert; Pencheva, Nora; Brunen, Diede; Bosma, Astrid; Song, Ji-Ying; Zevenhoven, John; Los-de Vries, G Tjitske; Horlings, Hugo; Nuijen, Bastiaan; Beijnen, Jos H; Schellens, Jan H M; Bernards, Rene.

Cell ; 173(6): 1413-1425.e14, 2018 05 31.

Artigo em Inglês | MEDLINE | ID: mdl-29754815

11.

Toward Minimal Residual Disease-Directed Therapy in Melanoma.

Rambow, Florian; Rogiers, Aljosja; Marin-Bejar, Oskar; Aibar, Sara; Femel, Julia; Dewaele, Michael; Karras, Panagiotis; Brown, Daniel; Chang, Young Hwan; Debiec-Rychter, Maria; Adriaens, Carmen; Radaelli, Enrico; Wolter, Pascal; Bechter, Oliver; Dummer, Reinhard; Levesque, Mitchell; Piris, Adriano; Frederick, Dennie T; Boland, Genevieve; Flaherty, Keith T; van den Oord, Joost; Voet, Thierry; Aerts, Stein; Lund, Amanda W; Marine, Jean-Christophe.

Cell ; 174(4): 843-855.e19, 2018 08 09.

Artigo em Inglês | MEDLINE | ID: mdl-30017245

12.

Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade.

Benci, Joseph L; Xu, Bihui; Qiu, Yu; Wu, Tony J; Dada, Hannah; Twyman-Saint Victor, Christina; Cucolo, Lisa; Lee, David S M; Pauken, Kristen E; Huang, Alexander C; Gangadhar, Tara C; Amaravadi, Ravi K; Schuchter, Lynn M; Feldman, Michael D; Ishwaran, Hemant; Vonderheide, Robert H; Maity, Amit; Wherry, E John; Minn, Andy J.

Cell ; 167(6): 1540-1554.e12, 2016 Dec 01.

Artigo em Inglês | MEDLINE | ID: mdl-27912061

13.

Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma.

Hugo, Willy; Zaretsky, Jesse M; Sun, Lu; Song, Chunying; Moreno, Blanca Homet; Hu-Lieskovan, Siwen; Berent-Maoz, Beata; Pang, Jia; Chmielowski, Bartosz; Cherry, Grace; Seja, Elizabeth; Lomeli, Shirley; Kong, Xiangju; Kelley, Mark C; Sosman, Jeffrey A; Johnson, Douglas B; Ribas, Antoni; Lo, Roger S.

Cell ; 165(1): 35-44, 2016 Mar 24.

Artigo em Inglês | MEDLINE | ID: mdl-26997480

14.

Loss of IFN-Î³ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy.

Gao, Jianjun; Shi, Lewis Zhichang; Zhao, Hao; Chen, Jianfeng; Xiong, Liangwen; He, Qiuming; Chen, Tenghui; Roszik, Jason; Bernatchez, Chantale; Woodman, Scott E; Chen, Pei-Ling; Hwu, Patrick; Allison, James P; Futreal, Andrew; Wargo, Jennifer A; Sharma, Padmanee.

Cell ; 167(2): 397-404.e9, 2016 Oct 06.

Artigo em Inglês | MEDLINE | ID: mdl-27667683

15.

Antigen and checkpoint receptor engagement recalibrates T cell receptor signal strength.

Elliot, Thomas A E; Jennings, Emma K; Lecky, David A J; Thawait, Natasha; Flores-Langarica, Adriana; Copland, Alastair; Maslowski, Kendle M; Wraith, David C; Bending, David.

Immunity ; 54(11): 2481-2496.e6, 2021 11 09.

Artigo em Inglês | MEDLINE | ID: mdl-34534438

16.

Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance.

Hugo, Willy; Shi, Hubing; Sun, Lu; Piva, Marco; Song, Chunying; Kong, Xiangju; Moriceau, Gatien; Hong, Aayoung; Dahlman, Kimberly B; Johnson, Douglas B; Sosman, Jeffrey A; Ribas, Antoni; Lo, Roger S.

Cell ; 162(6): 1271-85, 2015 Sep 10.

Artigo em Inglês | MEDLINE | ID: mdl-26359985

17.

PD-1 Blockers.

Wolchok, Jedd D.

Cell ; 162(5): 937, 2015 Aug 27.

Artigo em Inglês | MEDLINE | ID: mdl-26317459

18.

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.

Zelenay, Santiago; van der Veen, Annemarthe G; Böttcher, Jan P; Snelgrove, Kathryn J; Rogers, Neil; Acton, Sophie E; Chakravarty, Probir; Girotti, Maria Romina; Marais, Richard; Quezada, Sergio A; Sahai, Erik; Reis e Sousa, Caetano.

Cell ; 162(6): 1257-70, 2015 Sep 10.

Artigo em Inglês | MEDLINE | ID: mdl-26343581

19.

Broad-spectrum therapeutic suppression of metastatic melanoma through nuclear hormone receptor activation.

Pencheva, Nora; Buss, Colin G; Posada, Jessica; Merghoub, Taha; Tavazoie, Sohail F.

Cell ; 156(5): 986-1001, 2014 Feb 27.

Artigo em Inglês | MEDLINE | ID: mdl-24581497

20.

Non-cell-autonomous cancer progression from chromosomal instability.

Li, Jun; Hubisz, Melissa J; Earlie, Ethan M; Duran, Mercedes A; Hong, Christy; Varela, Austin A; Lettera, Emanuele; Deyell, Matthew; Tavora, Bernardo; Havel, Jonathan J; Phyu, Su M; Amin, Amit Dipak; Budre, Karolina; Kamiya, Erina; Cavallo, Julie-Ann; Garris, Christopher; Powell, Simon; Reis-Filho, Jorge S; Wen, Hannah; Bettigole, Sarah; Khan, Atif J; Izar, Benjamin; Parkes, Eileen E; Laughney, Ashley M; Bakhoum, Samuel F.

Nature ; 620(7976): 1080-1088, 2023 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-37612508

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