Relevance of Major Allergens in Weed Pollen Allergy.

INTRODUCTION: Weed pollen allergy is an important and in prevalence increasing cause of pollinosis in Europe and across the world. In this study we focus on the value of common diagnostic tools for detection of a sensitization to mugwort and English plantain, especially with regard to the clinical relevance of the sensitization. METHODS: Eighty weed pollen sensitized patients (41 to mugwort and 39 to English plantain) were assessed retrospectively regarding their clinical anamnesis, in-vivo tests (skin prick test [SPT] and allergen specific provocation) and in-vitro tests (immunoglobulin E [IgE] reactivity to purified natural allergen extract and specific allergen components in serum). RESULTS: 85% of mugwort and 83% of English plantain sensitizations could be diagnosed by SPT alone. Distinction between allergic and non-allergic patients could be made with clinical challenges solely. IgE serology revealed IgE antibodies against the native pollen extracts for mugwort in 98% and for English plantain in 90% of patients. Detection of major allergens nArt v 1, nArt v 3 and Pla l 1 did not add accuracy to the diagnosis. A vast majority of the weed pollen allergic patients was sensitized to >1 allergen. Minor allergens were found to be of less importance. CONCLUSION: The exact diagnosis of weed pollen allergy can be challenging due to confounding components in anamnesis and diagnostic tests. IgE-serology does not delineate allergic from sensitized patients. Component resolved diagnostics (CRD) can confirm, but not replace, extract based diagnostic methods, such as SPT, provocation tests or serology to native extracts. Hence, these are the gold standard diagnostic tools in weed pollen allergy up to now.

An Overview: The Toxicity of Ageratina adenophora on Animals and Its Possible Interventions.

Ageratina adenophora is one of the major invasive weeds that causes instability of the ecosystem. Research has reported that A. adenophora produces allelochemicals that inhibit the growth and development of food crops, and also contain some toxic compounds that cause toxicity to animals that consume it. Over the past decades, studies on the identification of major toxic compounds of A. adenophora and their toxic molecular mechanisms have been reported. In addition, weed control interventions, such as herbicides application, was employed to reduce the spread of A. adenophora. However, the development of therapeutic and prophylactic measures to treat the various A. adenophora-induced toxicities, such as hepatotoxicity, splenotoxicity and other related disorders, have not been established to date. The main toxic pathogenesis of A. adenophora is oxidative stress and inflammation. However, numerous studies have verified that some extracts and secondary metabolites isolated from A. adenophora possess anti-oxidation and anti-inflammation activities, which implies that these extracts can relieve toxicity and aid in the development of drug or feed supplements to treat poisoning-related disorders caused by A. adenophora. Furthermore, beneficial bacteria isolated from rumen microbes and A. adenophora can degrade major toxic compounds in A. adenophora so as to be developed into microbial feed additives to help ameliorate toxicity mediated by A. adenophora. This review presents an overview of the toxic mechanisms of A. adenophora, provides possible therapeutic strategies that are available to mitigate the toxicity of A. adenophora and introduces relevant information on identifying novel prophylactic and therapeutic measures against A. adenophora-induced toxicity.

Outdoor pollen is a trigger of child and adolescent asthma emergency department presentations: A systematic review and meta-analysis.

BACKGROUND: In the context of increased asthma exacerbations associated with climatic changes such as thunderstorm asthma, interest in establishing the link between pollen exposure and asthma hospital admissions has intensified. Here, we systematically reviewed and performed a meta-analysis of studies on pollen and emergency department (ED) attendance. METHODS: A search for studies with appropriate search strategy in MEDLINE, EMBASE, Web of Science and CINAHL was conducted. Each study was assessed for quality and risk of bias. The available evidence was summarized both qualitatively and meta-analysed using random-effects models when moderate heterogeneity was observed. RESULTS: Fourteen studies were included. The pollen taxa investigated differed between studies, allowing meta-analysis only of the effect of grass pollen. A statistically significant increase in the percentage change in the mean number of asthma ED presentations (MPC) (pooled results from 3 studies) was observed for an increase in 10 grass pollen grains per cubic metre of exposure 1.88% (95% CI = 0.94%, 2.82%). Time series studies showed positive correlations between pollen concentrations and ED presentations. Age-stratified studies found strongest associations in children aged 5-17 years old. CONCLUSION: Exposure to ambient grass pollen is an important trigger for childhood asthma exacerbations requiring ED attendance. As pollen exposure is increasingly a problem especially in relation to thunderstorm asthma, studies with uniform measures of pollen and similar analytical methods are necessary to fully understand its impact on human health.

Mediterranean Wild Edible Plants: Weeds or "New Functional Crops"?

The Mediterranean basin is a biodiversity hotspot of wild edible species, and their therapeutic and culinary uses have long been documented. Owing to the growing demand for wild edible species, there are increasing concerns about the safety, standardization, quality, and availability of products derived from these species collected in the wild. An efficient cultivation method for the species having promising nutraceutical values is highly desirable. In this backdrop, a hydroponic system could be considered as a reproducible and efficient agronomic practice to maximize yield, and also to selectively stimulate the biosynthesis of targeted metabolites. The aim of this report is to review the phytochemical and toxic compounds of some potentially interesting Mediterranean wild edible species. Herein, after a deep analysis of the literature, information on the main bioactive compounds, and some possibly toxic molecules, from fifteen wild edible species have been compiled. The traditional recipes prepared with these species are also listed. In addition, preliminary data about the performance of some selected species are also reported. In particular, germination tests performed on six selected species revealed that there are differences among the species, but not with crop species. "Domestication" of wild species seems a promising approach for exploiting these "new functional foods".

Estimation of the economic threshold of Leptochloa chinensis (Chinese sprangletop) in direct-seeded fine grain rice (Oryza sativa) / Estimativa do limiar econômico de Leptochloa chinensis (chinese sprangletop) em arroz de grão fino (Oryza sativa) em semeadura direta

Leptochloa chinensis (L.) Nees (Chinese sprangletop) is a weed that is becoming a serious threat in upland and lowland rice. A field study was conducted at the Agronomic Research Farm, University of Sargodha, Punjab, Pakistan, during the summer seasons of 2018 and 2019 to evaluate the effect of L. chinensis density on the yield of direct-seeded fine rice. Treatments comprised of L. chinensis densities of 0, 5, 10, 15, 20 and 25 plants m-2, and the experiment was laid out in a randomized complete block design with four replications of each treatment. The results suggest that the presence of L. chinensis significantly hampered the grain yield of direct-seeded rice. Weed infestation caused 63% and 69% yield losses where 25 L. chinensis plants m-2 were sustained in 2018 and 2019, respectively. Yield reduction was due to the reduction in 1000-grain weight (22.9 and 29.1%), number of tillers m-2 (65.8 and 60.0%), and number of grains panicle-1 (53.3 and 60%) in 2018 and 2019, respectively. The highest weed infestation (25 plants m-2) produced the highest weed dry biomass (687 and 669 g m-2), N uptake (19.3 and 19.3 kg ha-1), P uptake (1.92 and 2.32 kg ha-1), and K uptake (20.53 and 20.27 kg ha-1) in 2018 and 2019, respectively. The lowest weed infestation (5 plants m-2) produced minimum weed dry biomass (47 and 85 g m-2), N uptake (1.6 and 2.9), P uptake (0.3 and 0.5), and K uptake (1.7 and 30 kg ha-1) in 2018 and 2019, respectively. The economic threshold of L. chinensis as estimated to cause 6.73% and 6.08% yield loss by the prediction model was 1.70 and 1.73 plants m-2 during 2018 and 2019, respectively. It can be concluded that L. chinensis is a serious weed in direct-seeded rice and it should be controlled when its density reaches 1.70-1.73 plants m-2 to avoid significant yield losses.(AU)

Leptochloa chinensis (L.) Nees (chinese sprangletop) é uma planta daninha que está se tornando uma séria ameaça no arroz de terras altas e baixas. Um estudo de campo foi realizado na Fazenda de Pesquisa Agronômica, Universidade de Sargodha, Punjab, Paquistão, durante as estações de verão de 2018 e 2019 para avaliar o efeito da densidade de L. chinensis na produção de arroz fino de semeadura direta. Os tratamentos foram compostos por densidades de L. chinensis de 0, 5, 10, 15, 20 e 25 plantas m-2, e o experimento foi delineado em blocos casualizados com quatro repetições de cada tratamento. Os resultados sugerem que a presença de L. chinensis prejudicou significativamente a produtividade de grãos do arroz de semeadura direta. A infestação de ervas daninhas causou perdas de rendimento de 63% e 69%, onde 25 plantas de L. chinensis m-2 foram mantidas em 2018 e 2019, respectivamente. A redução da produtividade deveu-se à redução no peso de mil grãos (22,9 e 29,1%), número de perfilhos m-2 (65,8 e 60,0%) e número de panículas-1 (53,3 e 60%) em 2018 e 2019, respectivamente. A maior infestação de plantas daninhas (25 plantas m-2) produziu a maior biomassa seca de plantas daninhas (687 e 669 g m-2), absorção de N (19,3 e 19,3 kg ha-1), absorção de P (1,92 e 2,32 kg ha-1) , e absorção de K (20,53 e 20,27 kg ha-1) em 2018 e 2019, respectivamente. A menor infestação de plantas daninhas (5 plantas m-2) produziu biomassa seca mínima de plantas daninhas (47 e 85 g m-2), absorção de N (1,6 e 2,9), absorção de P (0,3 e 0,5) e absorção de K (1,7 e 30 kg ha-1) em 2018 e 2019, respectivamente. O limiar econômico de L. chinensis estimado para causar perda de rendimento de 6,73% e 6,08% pelo modelo de previsão foi de 1,70 e 1,73 plantas m-2 durante 2018 e 2019, respectivamente. Pode-se concluir que L. chinensis é uma planta daninha importante em arroz de semeadura direta e deve ser controlada quando sua densidade atingir 1,70-1,73 plantas m-2 para evitar perdas significativas de produtividade.(AU)

Weed interference in caupi beans (Vigna unguiculata) grown in Januária, north of Minas Gerais, Brazil / Interferência de plantas daninhas em feijão-caupi (Vigna unguiculata) cultivado em Januária, norte de Minas Gerais, Brasil

The degree of weed interference in an agricultural crop is influenced by edaphoclimatic characteristics, the management used in the environment and the period of coexistence between the weeds and the crop of interest. This study aimed to determine periods of weed interference in cowpea (Vigna unguiculata-Fabaceae) var. BRS Potengi in the semiarid of northern Minas Gerais, Brazil. Treatments consisted of periods of control and coexistence of cowpea with weeds under irrigated cultivation (0, 7, 14, 21, 28, 35, 42, 49, 56, 63, and 77 days after crop emergence). At the end of each period of coexistence and harvest time, weeds were quantified and identified, and dry matter was determined. Stem diameter, number of pods per plant, and grain yield were obtained for cowpea. The main weeds found were Cenchrus echinatus, Panicum maximum, Eleusine indica (Poaceae), and Amaranthus retroflexus (Amaranthaceae). The period before interference (PBI) occurred up to 9 days after emergence, the total period of interference prevention (TPIP) occurred up to 23days after emergence, and critical period of interference prevention (CPIP) was observed between 9 and 23days after emergence. Weed interference during the entire cowpea cycle reduced yield by 37% when compared to the control treatment.

O grau de interferência de plantas daninhas em uma cultura agrícola é influenciado pelas características edafoclimáticas, pelo manejo utilizado no ambiente e pelo período de convivência entre as plantas daninhas e a cultura de interesse. Este trabalho teve como objetivo determinar períodos de interferência de plantas daninhas em feijão-caupi (Vigna unguiculata-Fabaceae) var. BRS Potengi no semiárido do norte de Minas Gerais, Brasil. Os tratamentos consistiram em períodos de controle e convivência do feijão-caupi com plantas daninhas sob cultivo irrigado (0, 7, 14, 21, 28, 35, 42, 49, 56, 63 e 77 dias após a emergência da cultura). Ao final de cada período de convivência e época de colheita, as plantas daninhas foram quantificadas e identificadas, e a matéria seca foi determinada. O diâmetro do caule, número de vagens por planta e produtividade de grãos foram obtidos para o feijão-caupi. As principais plantas daninhas encontradas foram Cenchrus echinatus, Panicum maximum, Eleusine indica (Poaceae) e Amaranthus retroflexus (Amaranthaceae). O Período Anterior à Interferência (PAI) ocorreu até 9 dias após a emergência, o Período Total de Prevenção à interferência (PTPI) ocorreu até 23 dias após a emergência e o Período Crítico de Prevenção à Interferência (PCPI) foi observado entre 9 e 23 dias após a emergência. A interferência de plantas daninhas durante todo o ciclo do feijão-caupi reduziu a produtividade em 37% quando comparado ao tratamento controle.

Weed management and fertilization limit the potential of cassava productivity in subtropical environment / Manejo de plantas daninhas e fertilidade limitam o potencial de produtividade da mandioca em ambiente subtropical

The objectives of this study were to evaluate the response to fertilization and different weed control periods in the accumulation of dry matter of cassava leaves, stems, roots, and fresh mass roots yield. Two experiments were carried out on commercial fields in Ibarama, and Santa Maria municipalities located at the Rio Grande do Sul State, South Brazil, during the 2018/2019 growing season. Five treatments, varying chemical fertilizer applications and herbicides were used to represent management practices commonly used by farmers in Southern Brazil. The Simanihot process-based model simulated cassava growth, development, and productivity under potential conditions. Results show that the recommended dose of fertilizers and liming combined with pre-emergent herbicide and three mechanical weed clear management showed a 72% increase in root productivity compared to the management used by the average yield of smallholder farmers. Therefore, it is possible to reach 80% of the potential productivity by keeping the cassava crop free from weed interference and applying fertilizers. The presence of weeds during the first 100 days after planting reduced about 50% of the plant dry matter production in Ibarama and Santa Maria. Interestingly, it also affects 79.2%of fresh roots productivity in Ibarama.

Os objetivos deste trabalho foram avaliar a resposta à adubação e diferentes épocas de controle de plantas daninhas no acúmulo de matéria seca de folhas, hastes, raízes e produção de massa fresca de raízes de mandioca. Dois experimentos foram conduzidos em campos comerciais nos municípios de Ibarama e Santa Maria localizados no Rio Grande do Sul, Sul do Brasil, durante a safra 2018/2019. Cinco tratamentos, com aplicações variadas de fertilizantes químicos e herbicidas foram utilizados para representar as práticas de manejo comumente utilizadas pelos agricultores do Sul do Brasil. O modelo baseado no processo Simanihot foi usado para simular o crescimento, desenvolvimento e produtividade da mandioca sob condições potenciais. Os resultados mostram que a dose recomendada de fertilizantes e calagem combinados com herbicida pré-emergente e três manejos mecânicos de limpeza de plantas daninhas apresentaram um aumento de72% na produtividade de raízes em relação ao manejo utilizado pela produtividade média dos pequenos agricultores. Portanto, é possível atingir 80% do potencial de produtividade mantendo a cultura da mandioca livre de interferência de plantas daninhas e com aplicação de fertilizantes. A presença de plantas daninhas durante os primeiros 100 dias após o plantio reduziu cerca de 50% da produção de matéria seca da planta em Ibarama e Santa Maria e 79,2% da produtividade de raízes frescas em Ibarama.

Effect of weed interference in the production components of 'Lucy Brown' american lettuce / Efeito da interferência de plantas daninhas nos componentes de produção da alface americana 'Lucy Brown'

One of the main challenges faced bylettuce producers is the interference of weeds whichaffectscrop development and productivity.The aim of this study was to evaluate the occurrence of programmed weeding on the growth and production of Lucy Brown American lettuce.The experiment was carried out between March and May 2017 at the Federal University of Roraima Cauamé campus, in Boa Vista, Roraima, Brazil. The experimental design used was randomized blocks with six treatments, four replications and four lettuce plants per experimental unit. The treatments tested were as follows: 100% weed control (100% WC); weed control 5 days after transplanting (WC 5 DAT); weed control 10 days after transplanting (WC 10 DAT); weed control 15 days after transplanting (WC 15 DAT); weed control 20 days after transplanting (WC 20 DAT) and 100% without weed control (100% WWC). The following variables were evaluated: shootheight, stem height, stem diameter, number of leaves, leaf length, leaf width, root length, shoot freshweight, total fresh weight, shoot dry weightand productivity. The 'Lucy Brown'lettuce crop must be weed-freeafter 5 days of transplanting the seedlings to avoid productivitylosses. The lack of weed control in the cultivation of 'Lucy Brown' lettuce causes a 71.88% decrease in its productivity.(AU)

Um dos principais desafios enfrentados pelos produtores dealface é a interferência das plantas daninhas que afetam o desenvolvimento e produtividadedas culturas. Objetivou-se com este trabalho avaliar a ocorrência de capinas programadas de plantas daninhas sobre o crescimento e a produção da cultura da alface americana Lucy Brown. O experimento foi desenvolvido entre os meses de março e maio de 2017, no Campus do Cauamé, da Universidade Federal de Roraima, Boa Vista, Roraima, Brasil. O delineamento experimental foi blocos casualizados, com seis tratamentos e quatro repetições com quatro plantas de alface por unidade experimental. Foram testados os tratamentos: 100% controle de plantas daninhas (100% CPD), controle de plantas daninhas 5 dias após transplantio (CPD 5 DAT), controle de plantas daninhas 10 dias após transplantio (CPD10 DAT), controle de plantas daninhas 15 dias após transplantio (CPD 15 DAT), controle de plantas daninhas 20 dias após transplantio (CPD 20 DAT) e 100% sem controle de plantas daninhas (100% SCPD); sobre as variáveis: altura de planta, altura do caule, diâmetro do caule, número de folhas, comprimento da folha, largura da folha, comprimento da raiz, massa fresca da parte área, massa fresca total da planta, massa seca da parte aérea e produtividade. A alface americana "Lucy Brown" deve estar sem convivênciadas plantas daninhas a partir dos 5 dias do transplantio das mudas para evitar perdas de rendimento. No cultivo da alface americana "Lucy Brown", a ausência de controle das plantas daninhas causa decréscimo de 71,88% na sua produtividade.(AU)

An investigation of the effects of stage of ensilage on Nassella neesiana seeds, for reducing seed viability and injury to livestock.

The noxious weed Nassella neesiana is established on a wide range of productive land throughout southeastern Australia. N. neesiana seeds, when mature, are sharp, causing injury to livestock, thus posing a problem in fodder bales. To reduce infestations of agricultural weeds in situ, production of silage from weed-infested pastures is practised as part of integrated weed management (IWM). However, there is little data to demonstrate whether this process is useful to reduce infestations or the harmful properties of N. neesiana. Therefore, the minimum duration of ensilage required to reduce the viability of N. neesiana seeds was investigated, both with and without addition of ensilage inoculants in this process. Also, the decreasing propensity of the seeds to injure livestock, after various times and conditions of ensilage, was assessed. Ensilage inoculant reduced seed germination probability to zero after 35 days. When no inoculant was added, zero viability was achieved after 42 days. A qualitative assessment of the hardness of ensilaged seeds found seed husks were softer (and therefore safer) after 42 days, whether inoculant was used or not. Therefore, we suggest that both the viability of N. neesiana seeds and hardness of seed casings are significantly reduced after 42 days, thereby reducing the risks of seed dispersal and injury to livestock.

Las malezas, plantas incomprendidas / Weeds, misunderstood plants

Etiquetadas por la agricultura moderna como pestes, las plantas de origen espontáneo, en los campos de cultivos son conocidas como malezas. Una denominación que denota una influencia negativa derivada de la conceptualización del ser humano sobre algunas especies vegetales. Nombrar maleza a una planta es, a juicio de los autores, un criterio sesgado. Un estado del arte poco robusto, sobre las bondades de una especie la condena a ser clasificada como una especie no deseada. En la agricultura moderna lo no deseado es eliminado. Las malezas han sido condenadas desde el inicio mismo de las labores agrícolas. No se les ha dado la oportunidad de mostrar que también pueden proveer bondades a los sistemas de producción. La erradicación de malezas no ha funcionado de forma permanente en los campos de cultivo. Las especies espontaneas se han abierto paso en la agricultura moderna. Han superado adversidades en toda la historia de la agricultura. Siempre presentes en los campos de cultivo las malezas nos desafían a convivir con ellas desde un enfoque diferente. Se han dado ya pasos importantes en la investigación del uso alternativo de estas especies. La investigación que implique la convivencia en detrimento de la eliminación es necesaria. Es momento de dejar de odiar a las malezas e iniciar a comprenderlas como parte importante del ecosistema agrícola.

Designated by modern agriculture as pests, the spontaneous plants, in the croplands are known as weeds. A denomination that denotes a negative influence on the conceptualization of the human being over some plant species. Naming a plant as weed is according to the authors a biased criterion. A weak state of art, on the kindness of a species condemns it to be classified as an unwanted species. In modern agriculture the unwanted is eliminated. Weeds have been doomed since the beginning of agriculture. They have not been given the opportunity to show that they can also provide benefits to production systems. The eradication of weeds has not been permanently effective in the fields. The spontaneous species have made their way in modern agriculture. They have overcome adversity throughout the history of agriculture. Always present in the fields, weeds challenge us to live with them from a different perspective. Important steps have already been taken in the investigation of the alternative use of these species. Research that implies coexistence to the detriment of elimination is necessary. It is time to stop hating weeds and begin to understand them as an important part of the agricultural ecosystem.

Carcass and meat quality of rabbits fed Tithonia tubaeformis weed

The objective of this study was to use different parts of the Tithonia tubaeformis plant in feed for fattening rabbits and then observe the effects on carcass and meat quality. Forty-eight weaned rabbits (35 days of age) were randomly assigned to four groups (n = 12 by treatment). Animals were fed ad libitum a control diet as well as three experimental diets, with addition of Tithonia tubaeformis leaves, whole plant, and stems. Rabbits were slaughtered after 63 days of age without fasting. Results indicate that live weight (0.917), skin (0.79), feet (6.679), and lumbar circumference of the carcass (0.707) have higher positive correlations with hot carcass. There were no significant differences between treatments for all variables measured, except for kidneys and kidney fat. pH and color values were different among treatments. The results indicate that Tithonia tubaeformis leaves or the whole plant could be added to feed for growing rabbits.(AU)

Full thickness burn caused by exposure to giant hogweed: delayed presentation, histological features and surgical management.

We report the case of a 10-year-old boy with a full thickness chemical burn on his right pretibial area due to phytophotodermatitis (PPD) following contact with giant hogweed (Heracleum mantegazzianum). Although cutaneous burns due to plants are a well-established cause of chemical burn, previous reports described partial thickness burns that healed with conservative measures. This patient presented to our unit two weeks after the initial injury with an established full thickness burn. Debridement and split thickness skin grafting was required. We presented the histological features of the debrided skin specimen and discussed potential factors leading to this unexpected full thickness injury.

Conhecimento botânico medicinal sobre espécies vegetais nativas da caatinga e plantas espontâneas no agreste da Paraíba, Brasil / Botanical medical knowledge of native species of the Caatinga and spontaneous plants in the Agreste region of the state of Paraíba, Brazil

O bioma Caatinga apresenta diversas espécies vegetais amplamente empregadas pelas populações rurais, especialmente na fitoterapia, abrangendo diversos usos no tratamento de determinadas enfermidades. As plantas espontâneas, apesar de serem entendidas como espécies daninhas ou invasoras, concomitantemente apresentam propriedades fitoquímicas que podem ser aproveitadas no âmbito medicinal. Nesta concepção, o referente trabalho tem como objetivo identificar espécies vegetais nativas da Caatinga, assim como plantas espontâneas, empregadas na medicina popular através de estudo etnobotânico desenvolvido na zona rural do município de Serra da Raiz, Agreste da Paraíba, Nordeste do Brasil. O levantamento das plantas de uso fitoterápico foi estabelecido através de questionamentos e entrevistas semiestruturadas com 57 famílias da região. Foram coletadas informações referentes a 55 espécies vegetais e seus empregos terapêuticos, destacando-se entre elas: Myracrodruom urundeuva Allemão (Aroeira), Genipa americana L. (Jenipapo), Solanum paniculatum L. (Jurubeba) e Anadenanthera colubrina (Vell.) Brenan (Angico) por serem amplamente utilizadas no tratamento de diversas enfermidades pelos moradores locais.

The Brazilian Caatinga has several plant species widely used by rural populations, especially in phytotherapy, covering many uses in the treatment of diseases. The spontaneous plants, although regarded as invasive plants or weeds, present phytochemical properties that can be exploited in medicine. This study aims to identify native plant species of the Caatinga and spontaneous plants used in medicine through an ethnobotanical study developed in the municipality of Serra da Raiz, Agreste area of the state of Paraíba, Brazil. The survey of plants used in herbal medicine was established through the questioning of and semi-structured interviews with 57 families in the region. Information was record on 55 plant species and their therapeutic uses. The species most used in the treatment of various diseases were Myracrodruon urundeuva Allemão, Genipa americana L., Solanum paniculatum L. and Anadenanthera colubrina (Vell.) Brenan..