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CD14 and IL6 polymorphisms are associated with a pro-atherogenic profile in young adults with acute myocardial infarction
Limo-Neto, Lidio Gonçalves; Hirata, Rosario Domingues Crespo; Luchessi, André Ducati; Silbiger, Vivian Nogueira; Stephano, Marco Antonio; Sampaio, Marcelo Ferraz; Armaganijan, Dikran; Hirata, Mario Hiroyuki.
Afiliação
  • Limo-Neto, Lidio Gonçalves; Department of Clinical Analysis and Toxicology, Faculdade deCiencias Farmaceuticas, School of Pharmaceutical Sciences. University of Sao Paulo. São Paulo. BR
  • Hirata, Rosario Domingues Crespo; Department of Clinical Analysis and Toxicology, Faculdade deCiencias Farmaceuticas, School of Pharmaceutical Sciences. University of Sao Paulo. São Paulo. BR
  • Luchessi, André Ducati; Department of Clinical Analysis and Toxicology, Faculdade deCiencias Farmaceuticas, School of Pharmaceutical Sciences. University of Sao Paulo. São Paulo. BR
  • Silbiger, Vivian Nogueira; Department of Clinical Analysis and Toxicology, Faculdade deCiencias Farmaceuticas, School of Pharmaceutical Sciences. University of Sao Paulo. São Paulo. BR
  • Stephano, Marco Antonio; Department of Pharmaceutical Technology, School of Pharmaceutical Sciences, University of Sao Paulo. São Paulo. BR
  • Sampaio, Marcelo Ferraz; Institute Dante Pazzanese of Cardiology. São Paulo. BR
  • Armaganijan, Dikran; Institute Dante Pazzanese of Cardiology. São Paulo. BR
  • Hirata, Mario Hiroyuki; Department of Clinical Analysis and Toxicology, Faculdade deCiencias Farmaceuticas, School of Pharmaceutical Sciences. University of Sao Paulo. São Paulo. BR
J tromb Thrombolysis ; 36: 332-340, 20130000. tab
Article em En | SES-SP, SESSP-IDPCPROD, SES-SP | ID: biblio-1063721
Biblioteca responsável: BR79.1
Localização: BR79.1
ABSTRACT
Abstract This study investigated the relationship of polymorphismsin genes encoding CD14, IL-6 and TLR4 withmetabolic, inflammatory and endothelial markers in youngadults with acute myocardial infarction (AMI). Glucose,lipids, nitrate and inflammatory markers, flow mediatedvasodilatation (FMV) and flow mediated by nitrate (FMN)were evaluated in 102 AMI and 108 non-AMI (controlgroup) young individuals (% years). CD14 -260C[T(rs2569190), IL6 -174G[C (rs1800795) and TLR4c.896A[G (rs4986790) and TLR4 c.1196C[T (rs4986791)polymorphisms were analyzed by PCR–RFLP. Minor allelefrequencies of CD14, IL6 and TLR4 polymorphisms weresimilar between AMI and control groups (p[0.05). In AMIgroup, individuals carrying IL6 -174CC genotype hadhigher serum triglycerides, VLDL cholesterol and glucosecompared to the IL6 -174GG/GC genotype carriers(p84 2013-11-12
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Coleções: 06-national / BR Base de dados: SES-SP / SESSP-IDPCPROD Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2013 Tipo de documento: Article
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Coleções: 06-national / BR Base de dados: SES-SP / SESSP-IDPCPROD Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2013 Tipo de documento: Article