Hepatitis autouinmune en niños. Presentación inicial como falla hepática fulminante / Autoimmune hepatitis in children. Initial presentation of fulminant hepatic failure
Acta gastroenterol. latinoam
; 30(4): 245-7, 2000. ilus, tab
Article
em Es
| BINACIS
| ID: bin-11718
Biblioteca responsável:
BR1.1
ABSTRACT
There are few cases reported of autoinmune hepatitis (AIH) tipe 2 presenting as fulminant hepatic failure (FHF) in children. The purpose of this study was to report three girls with AIH type 2 that presented as FHF. METHODS:
Over a period of 12 years, 123 patients with AIH diagnosed based on international criteria, 9 (7 per cent were type 2.3 of them presented as FHF. Other etiologies (viral, metabolic and toxic) were ruled out. The treatment was started with prednisone (2 mg-kg-day) and azathioprine (2 mg-kg-day). EVOLUTION Patients 1 and 3 died while waiting for liver transplant (LT) at 72 and 48 hours after initiating medical treatment. Patient 2 underwent LT3 days after starting treatment, with excellent evolution at 3 years and 7 months of follow up.CONCLUSIONS:
1--AIH type 2 was very infrequent in our group. 2--33 per cent of cases had initial presentation as FHF. 3--The course of the disease was aggressive, not responding to immunosupreessive therapy. The evolution was unfavorable in all patients. 4--LT is an alternative treatment for this severe disease. (Au)
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Coleções:
06-national
/
AR
Base de dados:
BINACIS
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
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Child, preschool
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Female
/
Humans
Idioma:
Es
Ano de publicação:
2000
Tipo de documento:
Article