Schistosoma mansoni venom allergen-like proteins: phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity
Int. J. Parasitol.
; 49(8): p.593-599, 2019.
Article
em En
| SES-SP, SESSP-IBPROD, SES-SP
| ID: but-ib16098
Biblioteca responsável:
BR78.1
Localização: BR78.1
ABSTRACT
Schistosoma mansoni venom allergen-like proteins (SmVALs) are part of a diverse protein superfamily partitioned into two groups (group 1 and group 2). Phylogenetic analyses of group 1 SmVALs revealed that members could be segregated into subclades (A–D); these subclades share similar gene expression patterns across the parasite lifecycle and immunological cross-reactivity. Furthermore, whole-mount in situ hybridization demonstrated that the phylogenetically, transcriptionally and immunologically-related SmVAL4, 10, 18 and 19 (subclade C) were all localized to the pre-acetabular glands of immature cercariae. Our results suggest that SmVAL group 1 phylogenetic relationships, stage-specific transcriptional profiles and tissue localization are predictive of immunological cross-reactivity.
Texto completo:
1
Coleções:
06-national
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BR
Base de dados:
SES-SP
/
SESSP-IBPROD
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article