Forty-eight subjects who had received chloroquinetreatment for single or multiple malariainfections with a cumulative dose ranging from 1,050 to 27,000mg were included. The control group consisted of 37 healthy aged-matched subjects. Data was collected on amplitude and implicit time of the N1, P1 and N2 waves in the central macular hexagon (R1) and in five concentric rings at different retinal eccentriciti (R2-R6).
Results:
No significant difference was observed in any mfERG parameter between chloroquine treated patients and control subjects. A comparison with previous data obtained from patients with rheumatologic disorders in the same region of Brazilwho had received larger cumulative doses of chloroquine and had displayed mfERG changes, indicated that retinaltoxicity seems to be dependent on cumulative dose.