Prevalence of transthyretin cardiac amyloidosis in elderly patients diagnosed with heart failure / Prevalencia de amiloidosis cardiaca por transtirretina en pacientes de edad avanzada con diagnóstico de insuficiencia cardiaca
Jaramillo-Hidalgo, Javier; Quezada-Feijoó, Maribel; Ramos, Mónica; Toro, Rocío; Gómez-Pavón, Javier; Ayala-Muñoz, Rocío.
Rev. esp. geriatr. gerontol. (Ed. impr.)
; 58(1): 8-14, ene.-feb. 2023. tab, graf
Artigo
em Inglês
| IBECS (Espanha) | ID: ibc-216614
Objective:
There is increased interest in studying ATTR-CA, a pathology that primarily affects patients of geriatric age and is frequently underdiagnosed. We aim to establish the prevalence of ATTR-CA in a cohort of patients with a history of HFpEF and to describe its characteristics.Methods:
We conducted a prospective observational study. Patients ≥75 years, clinical history of HFpEF, atrial dilation ≥34ml/m2 and left ventricular wall thickening >13mm, were included. Demographic and analytical parameters were collected, and a comprehensive geriatric assessment was performed, along with a transthoracic echocardiogram and cardiac scintigraphy. Finally, telephone follow-up was carried out at 6 and 12 months.Results:
50 patients were recruited, mean age 86±6 years, 54% women. Age and functional class (III vs. IIIIV) were factors associated with presenting with ATTR-CA. Patients with positive scintigraphy had a median time to admission of 5.2 months (confidence interval [CI] 95% 010.9), while in those with negative scintigraphy, it was 12.2 months (95% CI 11.712.8); log-rank p=0.064. Patients with positive scintigraphy had a median time to the combined endpoint (death and readmission) of 1.9 months (95% CI 06.1), and patients with negative scintigraphy of 11.9 months (95% CI 11.712); log-rank p=0.027.Conclusions:
ATTR-CA appears to be a prevalent etiology in elderly patients within the spectrum of HFpEF. Patients with a diagnosis of ATTR-CA had a shorter time to admission for HF and the combined event of death and admission than patients with a negative result on scintigraphy. (AU)
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