Analysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats
Rezende, Antônio M; Santos, Eduardo Tarazona; Couto, Álvaro D'Almeida; Fontes, Cór Jésus F; Souza, José Maria de; Carvalho, Luzia H; Brito, Cristiana F. A.
REZENDE, Antônio M. et al. Analysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats. American Journal of Tropical Medicine and Hygiene, v. 80, n. 5, p. 729-733, 2009.
Artigo
em Inglês
| IED | ID: ied-3571
Few genetic markers have been described to analyze populations of Plasmodium vivax . The genetic variability of P. vivax has been analyzed mainly among isolates taken from areas ranging from hyper- to holoendemic areas. These studies of genetic variability have neglected many areas with different epidemiologic profiles. The purpose of this study was to analyze the genetic variability of P. vivax isolates from four different Brazilian Amazon areas. We chose to study the five most polymorphic tandem repeats (TRs) identified so far. All TRs studied were polymorphic in at least one studied population, with a modal allele at nearly all loci. Expected heterozygosity ranged from 0.462 to 0.666 and did not correlate with the repeat array length. The genetic distances among the populations varied from 0.027 to 0.241, and did not correlate with their geographic separation. Tandem repeats identified in P. vivax isolates failed to allow geographic clustering. / This work was supported by the Fundação de Amparo à Pesquisa de Minas Gerais (Fapemig), the Conselho Nacional de Pesquisa (CNPq), and PAPES/FIOCRUZ.
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