Diazo group electrophilicity in kinamycins and lomaiviticin A: potential insights into the molecular mechanism of antibacterial and antitumor activity.
J Am Chem Soc
; 124(9): 1854-5, 2002 Mar 06.
Article
em En
| MEDLINE
| ID: mdl-11866589
ABSTRACT
Theoretical and chemical studies of the reactivity of isoprekinamycin, the kinamycins, and the lomaiviticins support the proposal that these natural products exhibit enhanced diazonium salt character and may owe their antitumor antibiotic properties to their ability to act as electrophilic azo-coupling agents in vivo.
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01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article