Functionalized head-to-head hairpin polyamides: synthesis, double-stranded DNA-binding activity and affinity.
Bioorg Med Chem Lett
; 15(16): 3720-4, 2005 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-16005219
ABSTRACT
A series of 4 functionalized head-to-head-linked hairpin oligo(N-methylpyrrole) carboxamides with different linkers have been synthesized. Their ability to bind double-stranded DNA and sequence specificity were compared and the apparent Kd values of their DNA complexes were determined. These compounds, particularly those with iminodiacetic linkers, revealed a high affinity for DNA (Kd = 4.5-4.8 x 10(-9) M) and sequence specific recognition of 9-10 base pairs.
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01-internacional
Base de dados:
MEDLINE
Limite:
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article