[Neonatal lupus erythematosus: 4 cases and clinical review]. / Lupus eritematoso neonatal: 4 casos y revisión clínica.
Actas Dermosifiliogr
; 96(10): 690-6, 2005 Dec.
Article
em Es
| MEDLINE
| ID: mdl-16476322
ABSTRACT
Neonatal lupus erythematosus (NLE) is an infrequent disease in newborns caused by the transplacental passage of maternal Anti-Ro/SSA, Anti-La/SSB and/or Anti-U1 RNP antibodies. The most common manifestations are cutaneous and cardiac. We carried out a retrospective study of cases of NLE diagnosed in the last 10 years at the Hospital Universitario Insular in Gran Canaria. Complete data was obtained for 4 patients. Three cases had circulating Anti-Ro antibodies in the mother and in the newborns, while in the fourth case they were Anti-RNP. Two mothers were diagnosed with systemic lupus, one with mixed connective tissue disease and the other with leucocytoclastic vasculitis. The skin lesions consisted of urticaria-like and desquamative lesions. One patient presented with ulceration. The histological study of the urticaria-like lesions showed a non-specific perivascular infiltrate; the desquamative lesions were consistent with subacute lupus erythematosus.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Observational_studies
Limite:
Female
/
Humans
/
Infant
/
Male
/
Newborn
Idioma:
Es
Ano de publicação:
2005
Tipo de documento:
Article