The protective efficacy of chlamydial protease-like activity factor vaccination is dependent upon CD4+ T cells.
Cell Immunol
; 242(2): 110-7, 2006 Aug.
Article
em En
| MEDLINE
| ID: mdl-17116296
ABSTRACT
We have previously determined the protective efficacy of intranasal vaccination with chlamydial protease-like activity factor (CPAF) against genital chlamydial infection. Since T-helper 1 (Th1) responses are important for anti-chlamydial immunity, we examined the contribution of CD4(+) T cells in CPAF mediated immunity against intravaginal (i.vag.) Chlamydia muridarum infection in C57BL/6 mice. CPAF+IL-12 vaccination induced antigen-specific CD4(+) T cells that secreted elevated levels of IFN-gamma, and generated strong humoral responses. The protective effects of CPAF vaccination against genital chlamydial challenge were abrogated by anti-CD4 neutralizing antibody treatment. Moreover, anti-chlamydial immunity could be adoptively transferred to naïve recipients using CPAF-specific CD4(+) T cells. Therefore, CPAF mediated anti-chlamydial immunity is highly dependent upon antigen-specific CD4(+) T cells.
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Coleções:
01-internacional
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MEDLINE
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Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article