Paradoxical response to dopamine agonists in tardive dyskinesia.
Am J Psychiatry
; 134(7): 785-9, 1977 Jul.
Article
em En
| MEDLINE
| ID: mdl-17308
ABSTRACT
The authors conducted an extensive pharmacological analysis of a patient severely affected by tardive dyskinesia. No drug treatment gave lasting clinical improvement. Several agents recently recommended for this condition, dimethyl aminoethanol, clozapine, and thioridazine, failed to modify the dyskinesia. Reserpine caused a worsening of the symptoms. A paradoxical and unexpected improvement was observed with apomorphine injections and with low-dosage oral L-dopa. These two drugs may have acted by stimulating presynaptic inhibitory dopamine receptors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Ano de publicação:
1977
Tipo de documento:
Article