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Therapeutic strategies against inflammation and bone loss associated with osteomyelitis.
Marriott, Ian; Miller, Jeremy R; Sahraei, Mahnaz.
Afiliação
  • Marriott I; University of North Carolina at Charlotte, Department of Biology, 9201 University City Boulevard, Charlotte, NC 28223, USA. imarriot@uncc.edu
Curr Opin Investig Drugs ; 8(11): 887-98, 2007 Nov.
Article em En | MEDLINE | ID: mdl-17979022
Despite current treatment strategies, osteomyelitis is often refractory and recurrent. The bacteria responsible for osteomyelitis can invade bone-forming osteoblasts, which are active participants in the generation of damaging inflammation and bone loss at sites of infection. Therefore, strategies promoting cell-mediated immune responses while limiting inflammation are required for the treatment of chronic bone infections. This review describes the mechanisms utilized by resident bone cells to perceive bacteria, recruit leukocytes to sites of infection and promote osteoclast-mediated bone destruction, as well as novel targets for the therapeutic intervention of these processes.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2007 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2007 Tipo de documento: Article