A biogenetically-inspired synthesis of a ring-D model of kinamycin F: insights into the conformation of ring D.
Org Lett
; 10(3): 381-4, 2008 Feb 07.
Article
em En
| MEDLINE
| ID: mdl-18183994
ABSTRACT
An efficient three-step construction of the highly oxygenated D-ring of the kinamycin antibiotics is reported for a simple model system. A comparison of the spectroscopic characteristics of the synthetic models with those of natural kinamycin F, which is suspected to be the bioactive form of the kinamycins, leads to the conclusion that the favored D-ring conformation of kinamycin F differs from that of the other partially or fully acylated variants.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article