Emphasis on cell turnover in two hosts infected by bovine leukemia virus: a rationale for host susceptibility to disease.
Vet Immunol Immunopathol
; 125(1-2): 1-7, 2008 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-18513803
ABSTRACT
Bovine leukemia virus (BLV) is a deltaretrovirus that infects and induces accumulation of B-lymphocytes in the peripheral blood and lymphoid tissues of cattle, leading to leukemia/lymphoma. BLV can also be experimentally transmitted to sheep, in which disease appears earlier and at higher frequencies. Abnormal accumulation of leukemic B-lymphocytes results from an alteration of different parameters that include cell proliferation and death as well as migration to lymphoid tissues. Interestingly, B lymphocyte turnover is increased in BLV-infected sheep but reduced in cattle, revealing a potential relationship between cell kinetics and disease progression.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article