Competitive repair pathways in immunoglobulin gene hypermutation.
Philos Trans R Soc Lond B Biol Sci
; 364(1517): 613-9, 2009 Mar 12.
Article
em En
| MEDLINE
| ID: mdl-19010770
This review focuses on the contribution of translesion DNA polymerases to immunoglobulin gene hypermutation, in particular on the roles of DNA polymerase eta (Poleta) in the generation of mutations at A/T bases from the initial cytosine-targeted activation-induced cytidine deaminase (AID)-mediated deamination event, and of Polkappa, an enzyme of the same polymerase family, used as a substitute when Poleta is absent. The proposition that the UNG uracil glycosylase and the MSH2-MSH6 mismatch recognition complex are two competitive rather than alternative pathways in the processing of uracils generated by AID is further discussed.
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Coleções:
01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article