[Effect of different duration of clopidogrel pretreatment on platelet activation in patients undergoing stenting].
Zhonghua Wai Ke Za Zhi
; 47(6): 411-4, 2009 Mar 15.
Article
em Zh
| MEDLINE
| ID: mdl-19595223
ABSTRACT
OBJECTIVE:
To investigate the effect of two clopidogrel pretreatment duration on platelet activation in patients undergoing stenting.METHODS:
From July 2006 to December 2007 40 elective carotid or vertebral artery stenting patients were assigned into two groups Group A (n = 24) initiated clopidogrel (75 mg/d) > or = 5 d before stenting; group B (n = 16) initiated 3 - 4 days. Platelet-monocyte aggregates and fibrinogen receptors analyzed by flow cytometric, and platelet aggregation tests using optical aggregometry, as well as serum soluble CD40 ligand quantified by enzyme-linked immunosorbent assay were assessed in peripheral blood samples obtained immediately before and at 0.5, 18 h and 6 d after stenting.RESULTS:
Platelet-monocyte aggregates, fibrinogen receptors and serum soluble CD40 ligand were higher in group B than in group A (14.59% vs 8.70%, P = 0.012; 4.87% vs 2.42%, P = 0.024; 5.79 microg/L vs 2.64 microg/L, P = 0.020) at 18 h after stenting. Serum soluble CD40 ligand was higher in group B than in group A (0.49 microg/L vs 0.31 microg/L, P = 0.033) at 0.5 h after stenting.CONCLUSIONS:
Premedication before stenting with clopidogrel 75 mg/d merely 3 - 4 d may be insufficient to achieve adequate platelet inhibition, whereas clopidogrel initiated at least 5 d could obtain preferable clinical antiplatelet efficacy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Limite:
Adult
/
Aged
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Aged80
/
Female
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Humans
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Male
/
Middle aged
Idioma:
Zh
Ano de publicação:
2009
Tipo de documento:
Article