Discovery of pyrimidine benzimidazoles as Src-family selective Lck inhibitors. Part II.
Bioorg Med Chem Lett
; 19(23): 6691-5, 2009 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-19854052
ABSTRACT
A series of 4-amino-6-benzimidazole-pyrimidines was designed to target lymphocyte-specific tyrosine kinase (Lck), a member of the Src-family kinases (SFKs). These type II inhibitors were optimized using a cellular Lck-dependent proliferation assay and are capable of inhibiting Lck at single-digit nanomolar concentrations. This scaffold is likely to serve a valuable template for developing potent inhibitors of a number of SFKs.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article