Origins and evolution of the mechanisms regulating translation initiation in eukaryotes.
Trends Biochem Sci
; 35(2): 63-73, 2010 Feb.
Article
em En
| MEDLINE
| ID: mdl-19926289
ABSTRACT
Translation in eukaryotes is a complex process that is closely regulated, mainly at the initiation step. Both universal and lineage-specific mechanisms regulate translation initiation. Considerable progress in our understanding of the regulation of translation has been achieved, but how these regulatory mechanisms evolved remains poorly understood. New discoveries in different fields suggest that the mechanisms that regulate translation emerged at different times during the evolution of eukaryotes, and that some initially evolved independently of the translation apparatus and were later incorporated into it. Overall, the emerging view suggests that 'tinkering' (i.e. co-opting and assembling molecules and regulatory mechanisms from other cellular processes) contributed importantly to the development of the mechanisms that regulate translation initiation during eukaryotic evolution.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article