2' biaryl amides as novel and subtype selective M1 agonists. Part II: Further optimization and profiling.
Bioorg Med Chem Lett
; 20(12): 3545-9, 2010 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-20483599
ABSTRACT
Further optimization of the biaryl amide series via extensively exploring structure-activity relationships resulted in potent and subtype selective M(1) agonists exemplified by compounds 9a and 9j with good rat PK properties including CNS penetration. Synthesis, structure-activity relationships, subtype selectivity for M(1) over M(2-5), and DMPK properties of these novel compounds are described.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article