Interleukin-10 gene polymorphisms in association with susceptibility to chronic hepatitis C virus infection: a meta-analysis study.
Arch Virol
; 155(11): 1839-42, 2010 Nov.
Article
em En
| MEDLINE
| ID: mdl-20661604
ABSTRACT
A relationship between chronic hepatitis C virus (HCV) infection and interleukin-10 (IL-10) gene polymorphisms has been reported with controversial results in different studies. In an effort to solve this controversy, we quantitatively summarized ten studies on this relationship by means of meta-analysis. Our analysis included ten case-control studies with 992 cases of chronic HCV infection and 1,123 controls. Analyses were performed with STATA version 9.0. The results showed that the IL-10 -1082GG genotype significantly increased the risk for persistent HCV infection (AA vs. GG OR = 0.680, 95% CI = 0.489-0.947, P = 0.022; AG vs. GG OR = 0.608, 95% CI = 0.439-0.840, P = 0.003; GG vs. AG + AA OR = 1.570, 95% CI = 1.160-2.123, P = 0.003), but no statistically significant differences were observed between cases and controls for IL-10 -819C/T and IL-10 -592C/A polymorphisms (P > 0.05). In conclusion, this meta-analysis suggested that the IL-10 -1082GG genotype was associated with increased susceptibility for chronic HCV infection.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article