Your browser doesn't support javascript.
loading
Free light chains of immunoglobulins in the cerebrospinal fluid of human immunodeficiency virus type 1-infected patients.
Gallo, P; Piccinno, M G; De Rossi, A; Pagni, S; Amadori, A; Chieco-Bianchi, L; Tavolato, B.
Afiliação
  • Gallo P; Institute of Neurology, Interuniversity Center for Research on Cancer, University of Padova, Italy.
J Neuroimmunol ; 26(3): 229-38, 1990 Mar.
Article em En | MEDLINE | ID: mdl-2106530
ABSTRACT
The presence of immunoglobulin (Ig) free light chains (FLC) was investigated in the cerebrospinal fluid (CSF) of human immunodeficiency virus type 1 (HIV-1)-infected patients. Intrathecal synthesis of FLC was demonstrated in 80% of the patients, even in the absence of oligoclonal Ig. The FLC patterns were characterized by restricted heterogeneity with regard to both isoelectric point and the molecular weight, and were mainly composed by dimers rather than monomers. A striking prevalence of lambda FLC was also observed. Local production of FLC can be taken as a marker of an ongoing immunopathological process within the central nervous system (CNS) in HIV-1-infected patients. A deregulation of Ig production by intrathecally activated B cells may be hypothesized.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 1990 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 1990 Tipo de documento: Article