[Molecular actors in Alzheimer's disease: which diagnostic and therapeutic consequences?]. / Comment les acteurs moléculaires de la pathologie Alzheimer permettent de comprendre la démence ? Quelles conséquences diagnostiques et thérapeutiques ?

ABSTRACT

Alzheimer's disease is a neurodegenerative disorder characterized by neuropathological lesions amyloid deposits and neurofibrillary degeneration. However, the links between these two brain hallmarks are still poorly understood. Until now, mainly amyloid pathology has been targeted un many clinical trials without any success. Both new therapeutic strategies and diagnosis improvement are needed.