Designing Animal Models of Alzheimer's Disease with Amyloid Precursor Protein (APP) Transgenes.
Methods Mol Med
; 32: 249-70, 2000.
Article
em En
| MEDLINE
| ID: mdl-21318524
ABSTRACT
Amyloid precursor protein (APP) and Alzheimer's disease are irrevocably linked, as APP is cleaved to form the Aß peptides that are the major components of amyloid plaques. One of the most resilient hypotheses about the cause of AD centers on the Aß peptide; all genetic causes and risk factors can be fitted into a general "amyloid cascade hypothesis," which maintains that all pathology is initiated by an abnormal accumulation of Aß amyloid (1).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article